Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior
Gee, Christine E., Peterlik, Daniel, Neuhäuser, Christoph, Bouhelal, Rochdi, Kaupmann, Klemens, Laue, Grit, Uschold-Schmidt, Nicole, Feuerbach, Dominik, Zimmermann, Kaspar, Ofner, Silvio, Cryan, John F., van der Putten, Herman, Fendt, Markus, Vranesic, Ivo, Glatthar, Ralf, Flor, Peter J.
Published in The Journal of biological chemistry (18.04.2014)
Published in The Journal of biological chemistry (18.04.2014)
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A Selective Metabotropic Glutamate Receptor 7 Agonist: Activation of Receptor Signaling via an Allosteric Site Modulates Stress Parameters In vivo
Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner, Joachim Nozulak, Oliver Pescott, Snezana Lukic, Natacha Stoehr, Cedric Mombereau, Kuhn, Rainer, Kevin H. Mc Allister, van der Putten, Herman, Cryan, John F., Peter J. Flor, Scolnick, Edward M.
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2005)
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Distinct effects of IPSU and suvorexant on mouse sleep architecture
Hoyer, Daniel, Dürst, Thomas, Fendt, Markus, Jacobson, Laura H, Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Laue, Grit, Ofner, Silvio, Legangneux, Eric, Gee, Christine E
Published in Frontiers in neuroscience (01.01.2013)
Published in Frontiers in neuroscience (01.01.2013)
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Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors
Callander, Gabrielle E, Olorunda, Morenike, Monna, Dominique, Schuepbach, Edi, Langenegger, Daniel, Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Laue, Grit, Ofner, Silvio, Briard, Emmanuelle, Gee, Christine E, Jacobson, Laura H, Hoyer, Daniel
Published in Frontiers in neuroscience (01.01.2013)
Published in Frontiers in neuroscience (01.01.2013)
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Pharmacological Characterization of Some Selected 4,5-Dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-Hydroxyquinazoline-2,4-diones as (S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic Acid Receptor Antagonists
Catarzi, Daniela, Lenzi, Ombretta, Colotta, Vittoria, Varano, Flavia, Poli, Daniela, Filacchioni, Guido, Lingenhöhl, Kurt, Ofner, Silvio
Published in Chemical & Pharmaceutical Bulletin (01.07.2010)
Published in Chemical & Pharmaceutical Bulletin (01.07.2010)
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AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization
Vranesic, Ivo, Ofner, Silvio, Flor, Peter Josef, Bilbe, Graeme, Bouhelal, Rochdi, Enz, Albert, Desrayaud, Sandrine, McAllister, Kevin, Kuhn, Rainer, Gasparini, Fabrizio
Published in Bioorganic & medicinal chemistry (01.11.2014)
Published in Bioorganic & medicinal chemistry (01.11.2014)
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Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia
Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Gee, Christine E, Jacobson, Laura H, Laue, Grit, Ofner, Silvio, Chaudhari, Vinod, Badiger, Sangamesh, Pandit, Chetan, Wagner, Juergen, Hoyer, Daniel
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold
Gutmann, Sascha, Hinniger, Alexandra, Fendrich, Gabriele, Drückes, Peter, Antz, Sylvie, Mattes, Henri, Möbitz, Henrik, Ofner, Silvio, Schmiedeberg, Niko, Stojanovic, Aleksandar, Rieffel, Sebastien, Strauss, André, Troxler, Thomas, Glatthar, Ralf, Sparrer, Helmut
Published in The Journal of biological chemistry (12.06.2015)
Published in The Journal of biological chemistry (12.06.2015)
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A General Strategy for Targeting Drugs to Bone
Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel
Published in Angewandte Chemie International Edition (23.11.2015)
Published in Angewandte Chemie International Edition (23.11.2015)
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Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity
Koller, Manuel, Lingenhoehl, Kurt, Schmutz, Markus, Vranesic, Ivan-Toma, Kallen, Joerg, Auberson, Yves P., Carcache, David A., Mattes, Henri, Ofner, Silvio, Orain, David, Urwyler, Stephan
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding
Marzinzik, Andreas L., Amstutz, René, Bold, Guido, Bourgier, Emmanuelle, Cotesta, Simona, Glickman, J. Fraser, Götte, Marjo, Henry, Christelle, Lehmann, Sylvie, Hartwieg, J. Constanze D., Ofner, Silvio, Pellé, Xavier, Roddy, Thomas P., Rondeau, Jean-Michel, Stauffer, Frédéric, Stout, Steven J., Widmer, Armin, Zimmermann, Johann, Zoller, Thomas, Jahnke, Wolfgang
Published in ChemMedChem (01.11.2015)
Published in ChemMedChem (01.11.2015)
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6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists
Orain, David, Ofner, Silvio, Koller, Manuel, Carcache, David A., Froestl, Wolfgang, Allgeier, Hans, Rasetti, Vittorio, Nozulak, Joachim, Mattes, Henri, Soldermann, Nicolas, Floersheim, Philipp, Desrayaud, Sandrine, Kallen, Joerg, Lingenhoehl, Kurt, Urwyler, Stephan
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Gezielte Anreicherung von Wirkstoffen am Knochen am Beispiel von allosterischen FPPS‐Inhibitoren
Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean‐Michel
Published in Angewandte Chemie (23.11.2015)
Published in Angewandte Chemie (23.11.2015)
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NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats
Vassout, Annick, Veenstra, Siem, Hauser, Kathleen, Ofner, Silvio, Brugger, Felix, Schilling, Walter, Gentsch, Conrad
Published in Regulatory peptides (22.12.2000)
Published in Regulatory peptides (22.12.2000)
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Conference Proceeding
QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE
OFNER SILVIO, STAUFFER FREDERIC, MARZINZIK ANDREAS, COTESTA SIMONA, AMSTUTZ RENE, BOLD GUIDO, JAHNKE WOLFGANG, MUELLER HARTWIEG CONSTANZE, ZIMMERMANN JOHANN
Year of Publication 29.11.2010
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Year of Publication 29.11.2010
Patent
Gezielte Anreicherung von Wirkstoffen am Knochen am Beispiel von allosterischen FPPS-Inhibitoren
Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel
Published in Angewandte Chemie (23.11.2015)
Published in Angewandte Chemie (23.11.2015)
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N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: In vivo active AMPA and NMDA(glycine) antagonists
Auberson, Yves P., Acklin, Pierre, Bischoff, Serge, Moretti, Robert, Ofner, Silvio, Schmutz, Markus, Veenstra, Siem J.
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
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