Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G, Gaus, Hans, Liang, Xue-Hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Published in Nucleic acids research (20.06.2019)
Published in Nucleic acids research (20.06.2019)
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Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice
Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (07.05.2020)
Published in Nucleic acids research (07.05.2020)
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Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate
Satake, Noriko, Duong, Connie, Yoshida, Sakiko, Oestergaard, Michael, Chen, Cathy, Peralta, Rachael, Guo, Shuling, Seth, Punit P, Li, Yueju, Beckett, Laurel, Chung, Jong, Nolta, Jan, Nitin, Nitin, Tuscano, Joseph M
Published in Molecular medicine (Cambridge, Mass.) (01.01.2016)
Published in Molecular medicine (Cambridge, Mass.) (01.01.2016)
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.
Published in Nucleic acids research (01.11.2013)
Published in Nucleic acids research (01.11.2013)
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Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver
Miller, Colton M, Donner, Aaron J, Blank, Emma E, Egger, Andrew W, Kellar, Brianna M, Østergaard, Michael E, Seth, Punit P, Harris, Edward N
Published in Nucleic acids research (07.04.2016)
Published in Nucleic acids research (07.04.2016)
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Towards combining backbone and sugar constraint in 3'-3' bis-phosphonate tethered 2'-4' bridged LNA oligonucleotide trimers
Duchamp, Edouard, Vasquez, Guillermo, Firoozi, Neda, Freestone, Graeme C, Oestergaard, Michael, Seth, Punit P, Hanessian, Stephen
Published in RSC advances (26.07.2024)
Published in RSC advances (26.07.2024)
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MXD3 antisense oligonucleotide with superparamagnetic iron oxide nanoparticles: A new targeted approach for neuroblastoma
Yoshida, Sakiko, Duong, Connie, Oestergaard, Michael, Fazio, Michael, Chen, Cathy, Peralta, Rachael, Guo, Shuling, Seth, Punit P, Li, Yueju, Beckett, Laurel, Nitin, Nitin, Satake, Noriko
Published in Nanomedicine (01.02.2020)
Published in Nanomedicine (01.02.2020)
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HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
Mattis, Virginia B, Tom, Colton, Akimov, Sergey, Saeedian, Jasmine, Østergaard, Michael E, Southwell, Amber L, Doty, Crystal N, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Arjomand, Jamshid, Hayden, Michael R, Ross, Christopher A, Svendsen, Clive N
Published in Human molecular genetics (01.06.2015)
Published in Human molecular genetics (01.06.2015)
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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides
Østergaard, Michael E, Yu, Jinghua, Kinberger, Garth A, Wan, W. Brad, Migawa, Michael T, Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J, Murray, Heather M, Low, Audrey, Swayze, Eric E, Prakash, Thazha P, Seth, Punit P
Published in Bioconjugate chemistry (19.08.2015)
Published in Bioconjugate chemistry (19.08.2015)
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접합된 올리고뉴클레오타이드 및 이의 용도
SKYNNER MICHAEL, URBONAS LIUDVIKAS, VAN RIETSCHOTEN KATERINE, SETH PUNIT P, TANOWITZ MICHAEL, RIGBY MICHAEL, STANWAY STEVEN, CARRER MICHELE, OESTERGAARD MICHAEL
Year of Publication 16.05.2024
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Year of Publication 16.05.2024
Patent
Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
Mazur, Curt, Powers, Berit, Zasadny, Kenneth, Sullivan, Jenna M., Dimant, Hemi, Kamme, Fredrik, Hesterman, Jacob, Matson, John, Oestergaard, Michael, Seaman, Marc, Holt, Robert W., Qutaish, Mohammed, Polyak, Ildiko, Coelho, Richard, Gottumukkala, Vijay, Gaut, Carolynn M., Berridge, Marc, Albargothy, Nazira J., Kelly, Louise, Carare, Roxana O., Hoppin, Jack, Kordasiewicz, Holly, Swayze, Eric E., Verma, Ajay
Published in JCI insight (17.10.2019)
Published in JCI insight (17.10.2019)
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Synthesis and Duplex-Stabilizing Properties of Fluorinated N-Methanocarbathymidine Analogues Locked in the C3′-endo Conformation
Jung, Michael E., Dwight, Timothy A., Vigant, Frederic, Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.
Published in Angewandte Chemie International Edition (08.09.2014)
Published in Angewandte Chemie International Edition (08.09.2014)
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Journal Article
Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides
Østergaard, Michael E., Kumar, Pawan, Nichols, Josh, Watt, Andrew, Sharma, Pawan K., Nielsen, Poul, Seth, Punit P.
Published in Nucleic acid therapeutics (01.10.2015)
Published in Nucleic acid therapeutics (01.10.2015)
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Journal Article
결합 변형된 올리고머 화합물 및 이의 용도
DRURY III WILLIAM JOHN, SETH PUNIT P, ANDERSON BROOKE A, MIGAWA MICHAEL T, LIANG XUE HAI, OESTERGAARD MICHAEL
Year of Publication 17.05.2022
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Year of Publication 17.05.2022
Patent
Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
Kumar, Pawan, Østergaard, Michael E, Baral, Bharat, Anderson, Brooke A, Guenther, Dale C, Kaura, Mamta, Raible, Daniel J, Sharma, Pawan K, Hrdlicka, Patrick J
Published in Journal of organic chemistry (06.06.2014)
Published in Journal of organic chemistry (06.06.2014)
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Journal Article
Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugates
Satake, Noriko, Duong, Connie, Oestergaard, Michael, Yoshida, Sakiko, Chen, Cathy, Nolta, Jan A., Guo, Shuling, Seth, Punit, Nitin, Nitin, Tuscano, Joseph
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid
Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Wan, W. Brad, Yu, Jinghua, Kinberger, Garth A., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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696. Pre-Clinical Evaluation of Allele-Specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides
Southwell, Amber L., Skotte, Niels H., Caron, Nicholas, Kordasiewicz, Holly, Oestergaard, Michael, Doty, Crystal N., Villanueva, Erika B., Xie, Yuanyun, Felczak, Boguslaw, Freier, Susan M., Swayze, Eric E., Seth, Punit P., Frank Bennet, C., Hayden, Michael R.
Published in Molecular therapy (01.05.2015)
Published in Molecular therapy (01.05.2015)
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C5-Functionalized DNA, LNA, and α-L-LNA: Positional Control of Polarity-Sensitive Fluorophores Leads to Improved SNP-Typing
Østergaard, Michael E., Kumar, Pawan, Baral, Bharat, Guenther, Dale C., Anderson, Brooke A., Ytreberg, F. Marty, Deobald, Lee, Paszczynski, Andrzej J., Sharma, Pawan K., Hrdlicka, Patrick J.
Published in Chemistry : a European journal (07.03.2011)
Published in Chemistry : a European journal (07.03.2011)
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