Discovery of the First Potent and Orally Available Agonist of the Orphan G‑Protein-Coupled Receptor 52
Setoh, Masaki, Ishii, Naoki, Kono, Mitsunori, Miyanohana, Yuhei, Shiraishi, Eri, Harasawa, Toshiya, Ota, Hiroyuki, Odani, Tomoyuki, Kanzaki, Naoyuki, Aoyama, Kazunobu, Hamada, Teruki, Kori, Masakuni
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist
Negoro, Nobuyuki, Sasaki, Shinobu, Mikami, Satoshi, Ito, Masahiro, Suzuki, Masami, Tsujihata, Yoshiyuki, Ito, Ryo, Harada, Ayako, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Tanaka, Toshimasa, Kogame, Akifumi, Matsunaga, Shinichiro, Yasuma, Tsuneo, Momose, Yu
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Published in ACS medicinal chemistry letters (09.09.2010)
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Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent
Negoro, Nobuyuki, Sasaki, Shinobu, Mikami, Satoshi, Ito, Masahiro, Tsujihata, Yoshiyuki, Ito, Ryo, Suzuki, Masami, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Morohashi, Akio, Nonaka, Masami, Matsunaga, Shinichiro, Yasuma, Tsuneo, Momose, Yu
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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Reduced bactericidal activity and nitric oxide production in metallothionein-deficient macrophages in response to lipopolysaccharide stimulation
Itoh, Norio, Shibayama, Hiroshi, Kanekiyo, Masako, Namphung, Dunkokkuruad, Nakanishi, Tsuyoshi, Matsuyama, Akiko, Odani, Tomoyuki, Tanaka, Keiichi
Published in Toxicology (Amsterdam) (15.12.2005)
Published in Toxicology (Amsterdam) (15.12.2005)
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Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives
Kubo, Osamu, Takami, Kazuaki, Kamaura, Masahiro, Watanabe, Koji, Miyashita, Hirohisa, Abe, Shinichi, Matsuda, Kae, Tsujihata, Yoshiyuki, Odani, Tomoyuki, Iwasaki, Shinji, Kitazaki, Tomoyuki, Murata, Toshiki, Sato, Kenjiro
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Published in Bioorganic & medicinal chemistry (01.07.2021)
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Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach
Kamaura, Masahiro, Kubo, Osamu, Sugimoto, Hiromichi, Noguchi, Naoyoshi, Miyashita, Hirohisa, Abe, Shinichi, Matsuda, Kae, Tsujihata, Yoshiyuki, Odani, Tomoyuki, Iwasaki, Shinji, Murata, Toshiki, Sato, Kenjiro
Published in Bioorganic & medicinal chemistry (15.03.2021)
Published in Bioorganic & medicinal chemistry (15.03.2021)
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Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists
Sato, Kenjiro, Sugimoto, Hiromichi, Rikimaru, Kentaro, Imoto, Hiroshi, Kamaura, Masahiro, Negoro, Nobuyuki, Tsujihata, Yoshiyuki, Miyashita, Hirohisa, Odani, Tomoyuki, Murata, Toshiki
Published in Bioorganic & medicinal chemistry (01.03.2014)
Published in Bioorganic & medicinal chemistry (01.03.2014)
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Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists
Negoro, Nobuyuki, Sasaki, Shinobu, Ito, Masahiro, Kitamura, Shuji, Tsujihata, Yoshiyuki, Ito, Ryo, Suzuki, Masami, Takeuchi, Koji, Suzuki, Nobuhiro, Miyazaki, Junichi, Santou, Takashi, Odani, Tomoyuki, Kanzaki, Naoyuki, Funami, Miyuki, Tanaka, Toshimasa, Yasuma, Tsuneo, Momose, Yu
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition
Yamasaki, Takeshi, Hirose, Hideki, Yamashita, Tohru, Takakura, Nobuyuki, Morimoto, Sachie, Nakahata, Takashi, Kina, Asato, Nakano, Yoshihide, Okano Tamura, Yumiko, Sugama, Jun, Odani, Tomoyuki, Shimizu, Yuji, Iwasaki, Shinji, Watanabe, Masanori, Maekawa, Tsuyoshi, Kasai, Shizuo
Published in Bioorganic & medicinal chemistry (01.08.2017)
Published in Bioorganic & medicinal chemistry (01.08.2017)
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Kono, Mitsunori, Matsumoto, Takahiro, Imaeda, Toshihiro, Kawamura, Toru, Fujimoto, Shinji, Kosugi, Yohei, Odani, Tomoyuki, Shimizu, Yuji, Matsui, Hideki, Shimojo, Masato, Kori, Masakuni
Published in Bioorganic & medicinal chemistry (15.02.2014)
Published in Bioorganic & medicinal chemistry (15.02.2014)
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Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors
Yoneyama-Hirozane, Mariko, Deguchi, Kohei, Hirakawa, Takeshi, Ishii, Tsuyoshi, Odani, Tomoyuki, Matsui, Junji, Nakano, Yoshihide, Imahashi, Kenichi, Takakura, Nobuyuki, Chisaki, Ikumi, Takekawa, Shiro, Sakamoto, Junichi
Published in SLAS discovery (01.02.2018)
Published in SLAS discovery (01.02.2018)
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Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation
Treeck, Oliver, Odani, Tomoyuki, Itoh, Norio, Imai, Harue, Fujita, Sayaka, Kohroki, Jyunya, Nakanishi, Tsuyoshi, Diedrich, Klaus, Ortmann, Olaf, Tanaka, Keiichi, Vollmer, Günter
Published in Leukemia research (01.08.2002)
Published in Leukemia research (01.08.2002)
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