KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity
Fonseca-Fonseca, Luis Arturo, Nuñez-Figueredo, Yanier, Sánchez, Jeney Ramírez, Guerra, Maylin Wong, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Hernádez, René Delgado, Menezes-Filho, Noelio J., Costa, Teresa Cristina Silva, de Santana, Wagno Alcântara, Oliveira, Joana L., Segura-Aguilar, Juan, da Silva, Victor Diogenes Amaral, Costa, Silva Lima
Published in Neurotoxicity research (01.08.2019)
Published in Neurotoxicity research (01.08.2019)
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Journal Article
Preventive and therapeutic effects of JM-20 on paclitaxel-evoked painful peripheral neuropathy in rats
Bárbara B. Garrido-Suárez, Gabino Garrido, Addis Bellma Menéndez, Guillermo Aparicio, Odalys Valdés, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, René Delgado-Hernández
Published in Journal of pharmacy & pharmacognosy research (01.03.2021)
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Published in Journal of pharmacy & pharmacognosy research (01.03.2021)
Journal Article
Therapeutic potential of the novel hybrid molecule JM-20 against focal cortical ischemia in rats
Yanier Núñez Figueredo, Jeney Ramírez-Sanchez, Gisele Hansel, Gilberto L. Pardo-Andreu, Nelson Merino, Guillermo Aparicio, Rene Delgado-Hernández, Laura García-Pupo, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Diogo O. Souza
Published in Journal of pharmacy & pharmacognosy research (01.07.2016)
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Published in Journal of pharmacy & pharmacognosy research (01.07.2016)
Journal Article
A multi-target ligand (JM-20) prevents morphine-induced hyperalgesia in naïve and neuropathic rats
Garrido-Suárez, Bárbara B., Garrido, Gabino, Bellma-Menéndez, Addis, Aparicio-López, Guillermo, Valdés-Martínez, Odalys, Morales-Aguiar, Ruth A., Fernández-Pérez, Miguel D., Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René
Published in European journal of pharmacology (15.11.2024)
Published in European journal of pharmacology (15.11.2024)
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Journal Article
Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications
Silva, Fernanda D'Avila da, Galiciolli, Maria Eduarda de Andrade, Irioda, Ana Carolina, Oliveira, Cláudia Sirlene, Piccoli, Bruna Candia, Prestes, Alessandro de Souza, Borin, Bruna Cogo, Schuch, Andre Passaglia, Ochoa-Rodríguez, Estael, Nuñez-Figueredo, Yanier, Rocha, João Batista Teixeira da
Published in Blood cells, molecules, & diseases (01.05.2024)
Published in Blood cells, molecules, & diseases (01.05.2024)
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Journal Article
Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma
Goto, Renata Nishida, Sobral, Lays Martin, Sousa, Lucas Oliveira, Garcia, Cristiana Bernadelli, Lopes, Norberto Peporine, Marín-Prida, Javier, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Pardo-Andreu, Gilberto Lázaro, Curti, Carlos, Leopoldino, Andréia Machado
Published in European journal of pharmacology (15.01.2018)
Published in European journal of pharmacology (15.01.2018)
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Journal Article
JM-20 affects GABA neurotransmission in Caenorhabditis elegans
da Silva, Aline Franzen, Cordeiro, Larissa Marafiga, Soares, Marcell Vallandro, Zamberlan, Danielle Coradini, Baptista, Fabiane Bicca Obetine, da Silveira, Tássia Limana, Machado, Marina Lopes, Arantes, Leticia Priscilla, Nuñez-Figueredo, Yanier, Rodríguez, Estael Ochoa, Soares, Félix Alexandre Antunes
Published in Neurotoxicology (Park Forest South) (01.12.2022)
Published in Neurotoxicology (Park Forest South) (01.12.2022)
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Journal Article
Anti-hypernociceptive and anti-inflammatory effects of JM-20: A novel hybrid neuroprotective compound
Garrido-Suárez, Bárbara B., Garrido, Gabino, Castro-Labrada, Marian, Merino, Nelson, Valdés, Odalys, Pardo, Zenia, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Godoy-Figueiredo, Jozi, Ferreira, Sergio H.
Published in Brain research bulletin (01.12.2020)
Published in Brain research bulletin (01.12.2020)
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Journal Article
JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain
Ramírez-Sánchez, Jeney, Pires, Elisa Nicoloso Simões, Meneghetti, André, Hansel, Gisele, Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L., Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Salbego, Christianne, Souza, Diogo O
Published in Molecular neurobiology (2019)
Published in Molecular neurobiology (2019)
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Journal Article
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson’s disease: Mitochondrial protection and antioxidant properties
Fonseca-Fonseca, Luis Arturo, da Silva, Víctor Diogenes Amaral, Wong-Guerra, Maylin, Ramírez-Sánchez, Jeney, Yaquis, Alejandro Saúl Padrón, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, de Araújo, Fillipe Mendes, Santana, Rejane Conceição, Outeiro, Tiago Fleming, Costa, Silvia Lima, Núñez-Figueredo, Yanier
Published in Neurotoxicology (Park Forest South) (01.01.2021)
Published in Neurotoxicology (Park Forest South) (01.01.2021)
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Journal Article
Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion
Ramírez-Sánchez, Jeney, Wong-Guerra, Maylin, Fonseca-Fonseca, Luis Arturo, Simões-Pires, Elisa Nicoloso, García-Pupo, Laura, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Salbego, Christianne, Souza, Diogo O., Pardo-Andreu, Gilberto L., Nuñez-Figueredo, Yanier
Published in European journal of pharmacology (15.05.2021)
Published in European journal of pharmacology (15.05.2021)
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Journal Article
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo
Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Hansel, Gisele, Simões Pires, Elisa Nicoloso, Merino, Nelson, Valdes, Odalys, Delgado-Hernández, René, Parra, Alicia Lagarto, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Salbego, Christianne, Costa, Silvia L., Souza, Diogo O., Pardo-Andreu, Gilberto L.
Published in Neuropharmacology (01.10.2014)
Published in Neuropharmacology (01.10.2014)
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Journal Article
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+ -induced mitochondrial impairment
Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L, Ramírez-Sánchez, Jeney, Delgado-Hernández, René, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Naal, Zeki, Muller, Alexandre Pastoris, Portela, Luis Valmor, Souza, Diogo O
Published in Brain research bulletin (01.10.2014)
Published in Brain research bulletin (01.10.2014)
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Journal Article
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
Santos, Cleonice Creusa, Cardim-Pires, Thyago R., Shvachiy, Liana, Fonseca-Fonseca, Luis Arturo, Muñoz, Patricia, Almeida, Áurea Maria A. N., Costa, Ana Carla S., Teles-Souza, Jéssica, Ochoa-Rodríguez, Estael, de Fátima Dias Costa, Maria, Palhano, Fernando L., Segura-Aguilar, Juan, Barbosa, Deyse B., do Bomfim, Mayra R., dos Santos Junior, Manoelito C., Leite, Franco Henrique A., da Rocha Pita, Samuel Silva, Costa, Silvia Lima, Núñez-Figueredo, Yanier, Outeiro, Tiago Fleming, Foguel, Débora, Silva, Victor Diogenes Amaral
Published in Neurotoxicity research (01.12.2022)
Published in Neurotoxicity research (01.12.2022)
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Journal Article
Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway
Ramírez-Sánchez, Jeney, Simões Pires, Elisa Nicoloso, Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L., Fonseca-Fonseca, Luis Arturo, Ruiz-Reyes, Alberto, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Souza, Diogo O., Salbego, Christianne
Published in Neurochemistry international (01.11.2015)
Published in Neurochemistry international (01.11.2015)
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Journal Article
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro
Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Delgado-Hernández, René, Porto-Verdecia, Marlene, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Marin-Prida, Javier, González-Durruthy, Michael, Uyemura, Sergio A., Rodrigues, Fernando P., Curti, Carlos, Souza, Diogo O., Pardo-Andreu, Gilberto L.
Published in European journal of pharmacology (05.03.2014)
Published in European journal of pharmacology (05.03.2014)
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Journal Article
The effects of JM-20 on the glutamatergic system in synaptic vesicles, synaptosomes and neural cells cultured from rat brain
Nuñez-Figueredo, Yanier, Pardo Andreu, Gilberto L., Oliveira Loureiro, Samanta, Ganzella, Marcelo, Ramírez-Sánchez, Jeney, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Souza, Diogo O.
Published in Neurochemistry international (01.02.2015)
Published in Neurochemistry international (01.02.2015)
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Journal Article
Equilibrium solubility using shake-flask method of JM-20: a synthetic molecule with neuroprotective action
Luis O. Martínez Álvarez, Pedro L. Alejo Cisneros, Rionaldo Forte Mesa, Livania Quiñones Hinojosa, Abel Mondelo Rodríguez, Lisandra García Borges, Hugo Guerra Menéndez, Ángela Tuero Iglesias, Estael Ochoa Rodríguez, Miguel A. Cabrera Pérez
Published in Journal of pharmacy & pharmacognosy research (01.03.2020)
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Published in Journal of pharmacy & pharmacognosy research (01.03.2020)
Journal Article
Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources
D’Avila da Silva, Fernanda, Nogara, Pablo Andrei, Ochoa-Rodríguez, Estael, Nuñez-Figueredo, Yanier, Wong-Guerra, Maylin, Rosemberg, Denis Broock, Rocha, João Batista Teixeira da
Published in Biochimie (01.01.2020)
Published in Biochimie (01.01.2020)
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Journal Article
Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia
Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Pardo Andreu, Gilberto L., Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Souza, Diogo O.
Published in Pharmacological reports (01.08.2018)
Published in Pharmacological reports (01.08.2018)
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Journal Article