Highly Branched Poly(β-amino esters) for Non-Viral Gene Delivery: High Transfection Efficiency and Low Toxicity Achieved by Increasing Molecular Weight
Gao, Yongsheng, Huang, Jian-Yuan, O’Keeffe Ahern, Jonathan, Cutlar, Lara, Zhou, Dezhong, Lin, Feng-Huei, Wang, Wenxin
Published in Biomacromolecules (14.11.2016)
Published in Biomacromolecules (14.11.2016)
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Journal Article
Brushlike Cationic Polymers with Low Charge Density for Gene Delivery
O’Keeffe Ahern, Jonathan, A, Sigen, Zhou, Dezhong, Gao, Yongsheng, Lyu, Jing, Meng, Zhao, Cutlar, Lara, Pierucci, Luca, Wang, Wenxin
Published in Biomacromolecules (14.05.2018)
Published in Biomacromolecules (14.05.2018)
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Journal Article
Development of Branched Poly(5-Amino-1-pentanol-co-1,4-butanediol Diacrylate) with High Gene Transfection Potency Across Diverse Cell Types
Zhou, Dezhong, Gao, Yongsheng, O’Keeffe Ahern, Jonathan, A, Sigen, Xu, Qian, Huang, Xiaobei, Greiser, Udo, Wang, Wenxin
Published in ACS applied materials & interfaces (21.12.2016)
Published in ACS applied materials & interfaces (21.12.2016)
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Journal Article
Thermo- and pH-Responsive, Coacervate-Forming Hyperbranched Poly(β-amino ester)s for Selective Cell Binding
Zhou, Dezhong, Pierucci, Luca, Gao, Yongsheng, O’Keeffe Ahern, Jonathan, Huang, Xiaobei, Sigen, A, Wang, Wenxin
Published in ACS applied materials & interfaces (22.02.2017)
Published in ACS applied materials & interfaces (22.02.2017)
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Journal Article
Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system
O’Keeffe Ahern, Jonathan, Lara-Sáez, Irene, Zhou, Dezhong, Murillas, Rodolfo, Bonafont, Jose, Mencía, Ángeles, García, Marta, Manzanares, Darío, Lynch, Jennifer, Foley, Ruth, Xu, Qian, Sigen, A, Larcher, Fernando, Wang, Wenxin
Published in Gene therapy (01.04.2022)
Published in Gene therapy (01.04.2022)
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Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
Liu, Shuai, Gao, Yongsheng, Zhou, Dezhong, Zeng, Ming, Alshehri, Fatma, Newland, Ben, Lyu, Jing, O’Keeffe-Ahern, Jonathan, Greiser, Udo, Guo, Tianying, Zhang, Fengzhi, Wang, Wenxin
Published in Nature communications (24.07.2019)
Published in Nature communications (24.07.2019)
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Journal Article
A new developing class of gene delivery: messenger RNA-based therapeutics
Meng, Zhao, O'Keeffe-Ahern, Jonathan, Lyu, Jing, Pierucci, Luca, Zhou, Dezhong, Wang, Wenxin
Published in Biomaterials science (21.11.2017)
Published in Biomaterials science (21.11.2017)
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Journal Article
The transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery
Zhou, Dezhong, Cutlar, Lara, Gao, Yongsheng, Wang, Wei, O'Keeffe-Ahern, Jonathan, McMahon, Sean, Duarte, Blanca, Larcher, Fernando, Rodriguez, Brian J, Greiser, Udo, Wang, Wenxin
Published in Science advances (01.06.2016)
Published in Science advances (01.06.2016)
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Intramolecular Cyclization Dominating Homopolymerization of Multivinyl Monomers toward Single-Chain Cyclized/Knotted Polymeric Nanoparticles
Gao, Yongsheng, Zhou, Dezhong, Zhao, Tianyu, Wei, Xuan, McMahon, Sean, O’Keeffe Ahern, Jonathan, Wang, Wei, Greiser, Udo, Rodriguez, Brian J., Wang, Wenxin
Published in Macromolecules (13.10.2015)
Published in Macromolecules (13.10.2015)
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Journal Article
Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine
Huang, Xiaobei, Zhou, Dezhong, Zeng, Ming, Alshehri, Fatma, Li, Xiaolin, O’Keeffe-Ahern, Jonathan, Gao, Yongsheng, Pierucci, Luca, Greiser, Udo, Yin, Guangfu, Wang, Wenxin
Published in ACS macro letters (20.06.2017)
Published in ACS macro letters (20.06.2017)
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Journal Article
Highly Branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for High Performance Gene Transfection
Zeng, Ming, Zhou, Dezhong, Ng, Singwei, Ahern, Jonathan O Keeffe, Alshehri, Fatma, Gao, Yongsheng, Pierucci, Luca, Greiser, Udo, Wang, Wenxin
Published in Polymers (01.05.2017)
Published in Polymers (01.05.2017)
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Journal Article
Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy
Huang, Jian-Yuan, Gao, Yongsheng, Cutlar, Lara, O'Keeffe-Ahern, Jonathan, Zhao, Tianyu, Lin, Feng-Huei, Zhou, Dezhong, McMahon, Sean, Greiser, Udo, Wang, Wei, Wang, Wenxin
Published in Chemical communications (Cambridge, England) (18.05.2015)
Published in Chemical communications (Cambridge, England) (18.05.2015)
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Journal Article
Multifunctional oligomer incorporation: a potent strategy to enhance the transfection activity of poly(l-lysine)
Liu, Shuai, Yang, Jixiang, Ren, Hongqi, O'Keeffe-Ahern, Jonathan, Zhou, Dezhong, Zhou, Hao, Chen, Jiatong, Guo, Tianying
Published in Biomaterials science (01.03.2016)
Published in Biomaterials science (01.03.2016)
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Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapyElectronic supplementary information (ESI) available: Fig. S1, S2 and Experimental procedure. See DOI: 10.1039/c5cc02193f
Huang, Jian-Yuan, Gao, Yongsheng, Cutlar, Lara, O'Keeffe-Ahern, Jonathan, Zhao, Tianyu, Lin, Feng-Huei, Zhou, Dezhong, McMahon, Sean, Greiser, Udo, Wang, Wei, Wang, Wenxin
Year of Publication 05.05.2015
Year of Publication 05.05.2015
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Journal Article
Multifunctional oligomer incorporation: a potent strategy to enhance the transfection activity of poly(l-lysine)Electronic supplementary information (ESI) available. See DOI: 10.1039/c5bm00530b
Liu, Shuai, Yang, Jixiang, Ren, Hongqi, O'Keeffe-Ahern, Jonathan, Zhou, Dezhong, Zhou, Hao, Chen, Jiatong, Guo, Tianying
Year of Publication 23.02.2016
Year of Publication 23.02.2016
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Journal Article
HYPERBRANCHED CATIONIC POLYMERS USEFUL AS NUCLEIC ACID DELIVERY VECTORS FOR TRANSFECTING CELLS
ZHOU, Dezhong, O'KEEFFE AHERN, Jonathan, A, Sigen, WANG, Wenxin, LARA-SAEZ, Irene, XU, Qian
Year of Publication 20.09.2023
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Year of Publication 20.09.2023
Patent
HYPERBRANCHED CATIONIC POLYMERS USEFUL AS NUCLEIC ACID DELIVERY VECTORS FOR TRANSFECTING CELLS
ZHOU, Dezhong, O'KEEFFE AHERN, Jonathan, A, Sigen, WANG, Wenxin, LARA-SAEZ, Irene, XU, Qian
Year of Publication 20.09.2023
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Year of Publication 20.09.2023
Patent
HYPERBRANCHED CATIONIC POLYMERS USEFUL AS NUCLEIC ACID DELIVERY VECTORS FOR TRANSFECTING CELLS
Wang, Wenxin, O'Keeffe Ahern, Jonathan, Xu, Qian, A, Sigen, Lara-Saez, Irene, Zhou, Dezhong
Year of Publication 22.12.2022
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Year of Publication 22.12.2022
Patent
NANOPARTICLE COMPOSITIONS FOR GENE THERAPY
Wang, Wenxin, O'Keeffe Ahern, Jonathan, Xu, Qian, A, Sigen, Lara-Saez, Irene
Year of Publication 27.10.2022
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Year of Publication 27.10.2022
Patent
HYPERBRANCHED CATIONIC POLYMERS USEFUL AS NUCLEIC ACID DELIVERY VECTORS FOR TRANSFECTING CELLS
ZHOU, Dezhong, O'KEEFFE AHERN, Jonathan, A, Sigen, WANG, Wenxin, LARA-SAEZ, Irene, XU, Qian
Year of Publication 03.08.2022
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Year of Publication 03.08.2022
Patent