Efficacy of Intravenously Administered Gepotidacin in Cynomolgus Macaques following a Francisella tularensis Inhalational Challenge
Jakielaszek, Charles, Hilliard, Jamese J, Mannino, Frank, Hossain, Mohammad, Qian, Lian, Fishman, Cindy, Chou, Ying-Liang, Henning, Lisa, Novak, Joseph, Demons, Samandra, Hershfield, Jeremy, O'Dwyer, Karen
Published in Antimicrobial agents and chemotherapy (17.05.2023)
Published in Antimicrobial agents and chemotherapy (17.05.2023)
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Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production
Bailey, Andy M., Alberti, Fabrizio, Kilaru, Sreedhar, Collins, Catherine M., de Mattos-Shipley, Kate, Hartley, Amanda J., Hayes, Patrick, Griffin, Alison, Lazarus, Colin M., Cox, Russell J., Willis, Christine L., O’Dwyer, Karen, Spence, David W., Foster, Gary D.
Published in Scientific reports (04.05.2016)
Published in Scientific reports (04.05.2016)
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Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague
Jakielaszek, Charles, Hossain, Mohammad, Qian, Lian, Fishman, Cindy, Widdowson, Katherine, Hilliard, Jamese J, Mannino, Frank, Raychaudhuri, Aparna, Carniel, Elisabeth, Demons, Samandra, Heine, Henry S, Hershfield, Jeremy, Russo, Riccardo, Mega, William M, Revelli, David, O'Dwyer, Karen
Published in Science translational medicine (01.06.2022)
Published in Science translational medicine (01.06.2022)
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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections
O'Dwyer, Karen, Spivak, Aaron T, Ingraham, Karen, Min, Sharon, Holmes, David J, Jakielaszek, Charles, Rittenhouse, Stephen, Kwan, Alan L, Livi, George P, Sathe, Ganesh, Thomas, Elizabeth, Van Horn, Stephanie, Miller, Linda A, Twynholm, Monique, Tomayko, John, Dalessandro, Marybeth, Caltabiano, Madelyn, Scangarella-Oman, Nicole E, Brown, James R
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
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Comparative Analysis of the Antibacterial Activity of a Novel Peptide Deformylase Inhibitor, GSK1322322
O'DWYER, Karen, HACKEL, Meredith, HIGHTOWER, Sarah, HOBAN, Daryl, BOUCHILLON, Samuel, DONGHUI QIN, AUBART, Kelly, ZALACAIN, Magdalena, BUTLER, Deborah
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
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Potent Sub-MIC Effect of GSK1322322 and Other Peptide Deformylase Inhibitors on In Vitro Growth of Staphylococcus aureus
BUTLER, Deborah, DONGZHAO CHEN, O'DWYER, Karen, LEWANDOWSKI, Thomas, AUBART, Kelly, ZALACAIN, Magdalena
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
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Characterization of a Novel Fucose-Regulated Promoter (PfcsK) Suitable for Gene Essentiality and Antibacterial Mode-of-Action Studies in Streptococcus pneumoniae
Chan, Pan F, O'Dwyer, Karen M, Palmer, Leslie M, Ambrad, Jennifer D, Ingraham, Karen A, So, Chi, Lonetto, Michael A, Biswas, Sanjoy, Rosenberg, Martin, Holmes, David J, Zalacain, Magdalena
Published in Journal of Bacteriology (01.03.2003)
Published in Journal of Bacteriology (01.03.2003)
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A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function
Zalacain, Magdalena, Biswas, Sanjoy, Ingraham, Karen A, Ambrad, Jennifer, Bryant, Alexander, Chalker, Alison F, Iordanescu, Serban, Fan, Jing, Fan, Frank, Lunsford, R Dwayne, O'Dwyer, Karen, Palmer, Leslie M, So, Chi, Sylvester, Daniel, Volker, Craig, Warren, Patrick, McDevitt, Damien, Brown, James R, Holmes, David J, Burnham, Martin K R
Published in Journal of molecular microbiology and biotechnology (01.01.2003)
Published in Journal of molecular microbiology and biotechnology (01.01.2003)
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Characterization of Streptococcus pneumoniae TrmD, a tRNA Methyltransferase Essential for Growth
O'DWYER, Karen, WATTS, Joseph M, BISWAS, Sanjoy, AMBRAD, Jennifer, BARBER, Michael, BRULE, Hervé, PETIT, Chantal, HOLMES, David J, ZALACAIN, Magdalena, HOLMES, Walter M
Published in Journal of Bacteriology (01.04.2004)
Published in Journal of Bacteriology (01.04.2004)
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Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax
Hilliard, Jamese J, Jakielaszek, Charles, Mannino, Frank, Hossain, Mohammad, Qian, Lian, Fishman, Cindy, Demons, Samandra, Hershfield, Jeremy, Soffler, Carl, Russo, Riccardo, Henning, Lisa, Novak, Joseph, O'Dwyer, Karen
Published in Antimicrobial agents and chemotherapy (06.03.2024)
Published in Antimicrobial agents and chemotherapy (06.03.2024)
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Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
Min, Sharon, Ingraham, Karen, Huang, Jianzhong, McCloskey, Lynn, Rilling, Sarah, Windau, Anne, Pizzollo, Jason, Butler, Deborah, Aubart, Kelly, Miller, Linda A, Zalacain, Magdalena, Holmes, David J, O'Dwyer, Karen
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Published in Antimicrobial agents and chemotherapy (01.08.2015)
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Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to α-ketoamide inhibitors
Bruton, Gordon, Huxley, Anthony, O'Hanlon, Peter, Orlek, Barry, Eggleston, Drake, Humphries, John, Readshaw, Simon, West, Andrew, Ashman, Stephen, Brown, Murray, Moore, Keith, Pope, Andrew, O'Dwyer, Karen, Wang, Lei
Published in European journal of medicinal chemistry (01.04.2003)
Published in European journal of medicinal chemistry (01.04.2003)
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