Genetic code flexibility in microorganisms: novel mechanisms and impact on physiology
Ling, Jiqiang, O'Donoghue, Patrick, Söll, Dieter
Published in Nature reviews. Microbiology (01.11.2015)
Published in Nature reviews. Microbiology (01.11.2015)
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Journal Article
Biosynthesis, Engineering, and Delivery of Selenoproteins
Wright, David E, O'Donoghue, Patrick
Published in International journal of molecular sciences (22.12.2023)
Published in International journal of molecular sciences (22.12.2023)
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Journal Article
Upgrading protein synthesis for synthetic biology
O'Donoghue, Patrick, Ling, Jiqiang, Wang, Yane-Shih, Söll, Dieter
Published in Nature chemical biology (01.10.2013)
Published in Nature chemical biology (01.10.2013)
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Journal Article
UGA is an additional glycine codon in uncultured SR1 bacteria from the human microbiota
Campbell, James H., O'Donoghue, Patrick, Campbell, Alisha G., Schwientek, Patrick, Sczyrba, Alexander, Woyke, Tanja, Söll, Dieter, Podar, Mircea
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
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Journal Article
Pathways to disease from natural variations in human cytoplasmic tRNAs
Lant, Jeremy T., Berg, Matthew D., Heinemann, Ilka U., Brandl, Christopher J., O’Donoghue, Patrick
Published in The Journal of biological chemistry (05.04.2019)
Published in The Journal of biological chemistry (05.04.2019)
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Journal Article
Formation and persistence of polyglutamine aggregates in mistranslating cells
Lant, Jeremy T, Kiri, Rashmi, Duennwald, Martin L, O’Donoghue, Patrick
Published in Nucleic acids research (18.11.2021)
Published in Nucleic acids research (18.11.2021)
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Journal Article
Editorial: Synthetic biology and therapeutic applications of transfer RNA
Söll, Dieter, O'Donoghue, Patrick, Heinemann, Ilka U
Published in Frontiers in genetics (14.08.2024)
Published in Frontiers in genetics (14.08.2024)
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Journal Article
Mechanisms and Delivery of tRNA Therapeutics
Ward, Cian, Beharry, Aruun, Tennakoon, Rasangi, Rozik, Peter, Wilhelm, Sarah D. P., Heinemann, Ilka U., O’Donoghue, Patrick
Published in Chemical reviews (26.06.2024)
Published in Chemical reviews (26.06.2024)
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Journal Article
Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics
Slattery, Samuel S., Giguere, Daniel J., Stuckless, Emily E., Shrestha, Arina, Briere, Lee-Ann K., Galbraith, Alexa, Reaume, Stephen, Boyko, Xenia, Say, Henry H., Browne, Tyler S., Frederick, Mallory I., Lant, Jeremy T., Heinemann, Ilka U., O’Donoghue, Patrick, Dsouza, Liann, Martin, Steven, Howard, Peter, Jedeszko, Christopher, Ali, Kinza, Styba, Garth, Flatley, Martin, Karas, Bogumil J., Gloor, Gregory B., Edgell, David R.
Published in Scientific reports (29.04.2022)
Published in Scientific reports (29.04.2022)
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Journal Article
Polyspecific pyrrolysyl-tRNA synthetases from directed evolution
Guo, Li-Tao, Wang, Yane-Shih, Nakamura, Akiyoshi, Eiler, Daniel, Kavran, Jennifer M., Wong, Margaret, Kiessling, Laura L., Steitz, Thomas A., O'Donoghue, Patrick, Söll, Dieter
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
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Journal Article
Missense suppressor tRNA therapeutics correct disease-causing alleles by misreading the genetic code
Bily, Teija M.I., Heinemann, Ilka U., O’Donoghue, Patrick
Published in Molecular therapy (07.02.2024)
Published in Molecular therapy (07.02.2024)
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Journal Article
Phosphorylation-Dependent Inhibition of Akt1
Balasuriya, Nileeka, McKenna, McShane, Liu, Xuguang, Li, Shawn S C, O'Donoghue, Patrick
Published in Genes (07.09.2018)
Published in Genes (07.09.2018)
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Journal Article
Biochemistry of Synthetic Biology - Recent Developments
O’Donoghue, Patrick, Heinemann, Ilka U.
Published in Biochimica et biophysica acta. General subjects (01.11.2017)
Published in Biochimica et biophysica acta. General subjects (01.11.2017)
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Journal Article
Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity
Balasuriya, Nileeka, Kunkel, Maya T., Liu, Xuguang, Biggar, Kyle K., Li, Shawn S.-C., Newton, Alexandra C., O'Donoghue, Patrick
Published in The Journal of biological chemistry (06.07.2018)
Published in The Journal of biological chemistry (06.07.2018)
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Journal Article
Ancestral archaea expanded the genetic code with pyrrolysine
Guo, Li-Tao, Amikura, Kazuaki, Jiang, Han-Kai, Mukai, Takahito, Fu, Xian, Wang, Yane-Shih, O’Donoghue, Patrick, Söll, Dieter, Tharp, Jeffery M.
Published in The Journal of biological chemistry (01.11.2022)
Published in The Journal of biological chemistry (01.11.2022)
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Journal Article
A novel fluorescent reporter sensitive to serine mis-incorporation
Rozik, Peter, Szabla, Robert, Lant, Jeremy T., Kiri, Rashmi, Wright, David E., Junop, Murray, O'Donoghue, Patrick
Published in RNA biology (31.12.2022)
Published in RNA biology (31.12.2022)
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Journal Article