A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
Rice, Siobhan, Jackson, Thomas, Crump, Nicholas T, Fordham, Nicholas, Elliott, Natalina, O'Byrne, Sorcha, Fanego, Maria Del Mar Lara, Addy, Dilys, Crabb, Trisevgeni, Dryden, Carryl, Inglott, Sarah, Ladon, Dariusz, Wright, Gary, Bartram, Jack, Ancliff, Philip, Mead, Adam J, Halsey, Christina, Roberts, Irene, Milne, Thomas A, Roy, Anindita
Published in Nature communications (25.11.2021)
Published in Nature communications (25.11.2021)
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Journal Article
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells
Godfrey, Laura, Crump, Nicholas T, O'Byrne, Sorcha, Lau, I-Jun, Rice, Siobhan, Harman, Joe R, Jackson, Thomas, Elliott, Natalina, Buck, Gemma, Connor, Christopher, Thorne, Ross, Knapp, David J H F, Heidenreich, Olaf, Vyas, Paresh, Menendez, Pablo, Inglott, Sarah, Ancliff, Philip, Geng, Huimin, Roberts, Irene, Roy, Anindita, Milne, Thomas A
Published in Leukemia (01.01.2021)
Published in Leukemia (01.01.2021)
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Journal Article
Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs
O'Byrne, Sorcha, Elliott, Natalina, Rice, Siobhan, Buck, Gemma, Fordham, Nicholas, Garnett, Catherine, Godfrey, Laura, Crump, Nicholas T., Wright, Gary, Inglott, Sarah, Hua, Peng, Psaila, Bethan, Povinelli, Benjamin, Knapp, David J.H.F., Agraz-Doblas, Antonio, Bueno, Clara, Varela, Ignacio, Bennett, Phillip, Koohy, Hashem, Watt, Suzanne M., Karadimitris, Anastasios, Mead, Adam J., Ancliff, Phillip, Vyas, Paresh, Menendez, Pablo, Milne, Thomas A., Roberts, Irene, Roy, Anindita
Published in Blood (26.09.2019)
Published in Blood (26.09.2019)
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Journal Article
Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development
Roy, Anindita, Wang, Guanlin, Iskander, Deena, O’Byrne, Sorcha, Elliott, Natalina, O’Sullivan, Jennifer, Buck, Gemma, Heuston, Elisabeth F., Wen, Wei Xiong, Meira, Alba Rodriguez, Hua, Peng, Karadimitris, Anastasios, Mead, Adam J., Bodine, David M., Roberts, Irene, Psaila, Bethan, Thongjuea, Supat
Published in Cell reports (Cambridge) (14.09.2021)
Published in Cell reports (Cambridge) (14.09.2021)
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Journal Article
Blood and immune development in human fetal bone marrow and Down syndrome
Jardine, Laura, Webb, Simone, Goh, Issac, Quiroga Londoño, Mariana, Reynolds, Gary, Mather, Michael, Olabi, Bayanne, Stephenson, Emily, Botting, Rachel A, Horsfall, Dave, Engelbert, Justin, Maunder, Daniel, Mende, Nicole, Murnane, Caitlin, Dann, Emma, McGrath, Jim, King, Hamish, Kucinski, Iwo, Queen, Rachel, Carey, Christopher D, Shrubsole, Caroline, Poyner, Elizabeth, Acres, Meghan, Jones, Claire, Ness, Thomas, Coulthard, Rowen, Elliott, Natalina, O'Byrne, Sorcha, Haltalli, Myriam L R, Lawrence, John E, Lisgo, Steven, Balogh, Petra, Meyer, Kerstin B, Prigmore, Elena, Ambridge, Kirsty, Jain, Mika Sarkin, Efremova, Mirjana, Pickard, Keir, Creasey, Thomas, Bacardit, Jaume, Henderson, Deborah, Coxhead, Jonathan, Filby, Andrew, Hussain, Rafiqul, Dixon, David, McDonald, David, Popescu, Dorin-Mirel, Kowalczyk, Monika S, Li, Bo, Ashenberg, Orr, Tabaka, Marcin, Dionne, Danielle, Tickle, Timothy L, Slyper, Michal, Rozenblatt-Rosen, Orit, Regev, Aviv, Behjati, Sam, Laurenti, Elisa, Wilson, Nicola K, Roy, Anindita, Göttgens, Berthold, Roberts, Irene, Teichmann, Sarah A, Haniffa, Muzlifah
Published in Nature (London) (14.10.2021)
Published in Nature (London) (14.10.2021)
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Journal Article
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
Kerry, Jon, Godfrey, Laura, Repapi, Emmanouela, Tapia, Marta, Blackledge, Neil P., Ma, Helen, Ballabio, Erica, O’Byrne, Sorcha, Ponthan, Frida, Heidenreich, Olaf, Roy, Anindita, Roberts, Irene, Konopleva, Marina, Klose, Robert J., Geng, Huimin, Milne, Thomas A.
Published in Cell reports (Cambridge) (10.01.2017)
Published in Cell reports (Cambridge) (10.01.2017)
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Journal Article
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
Louka, Eleni, Povinelli, Benjamin, Rodriguez-Meira, Alba, Buck, Gemma, Wen, Wei Xiong, Wang, Guanlin, Sousos, Nikolaos, Ashley, Neil, Hamblin, Angela, Booth, Christopher A G, Roy, Anindita, Elliott, Natalina, Iskander, Deena, de la Fuente, Josu, Fordham, Nicholas, O'Byrne, Sorcha, Inglott, Sarah, Norfo, Ruggiero, Salio, Mariolina, Thongjuea, Supat, Rao, Anupama, Roberts, Irene, Mead, Adam J
Published in The Journal of experimental medicine (01.02.2021)
Published in The Journal of experimental medicine (01.02.2021)
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Journal Article
CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies
Bueno, Clara, Barrera, Susana, Bataller, Alex, Ortiz-Maldonado, Valentín, Elliot, Natalina, O'Byrne, Sorcha, Wang, Guanlin, Rovira, Montse, Gutierrez-Agüera, Francisco, Trincado, Juan L, González-González, María, Morgades, Mireia, Sorigué, Marc, Bárcena, Paloma, Zanetti, Samanta Romina, Torrebadell, Montse, Vega-Garcia, Nerea, Rives, Susana, Mallo, Mar, Sole, Francesc, Mead, Adam J, Roberts, Irene, Thongjuea, Supat, Psaila, Bethan, Juan, Manel, Delgado, Julio, Urbano-Ispizúa, Alvaro, Ribera, Josep María, Orfao, Alberto, Roy, Anindita, Menendez, Pablo
Published in Blood (07.07.2022)
Published in Blood (07.07.2022)
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Journal Article
Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome
O'Byrne, Sorcha Isabella, Elliott, Natalina, Buck, Gemma, Rice, Siobhan, O'Connor, David, Oswald, Jana, Fuchs, Hannah, Labbett, Ella-Mae, Fordham, Nicholas James, Roy, Anindita, Roberts, Irene
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
3135 – CD34+CD19-CD22+ B-CELL PROGENITORS MIGHT UNDERLIE PHENOTYPIC ESCAPE IN PATIENTS TREATED WITH CD19-DIRECTED THERAPIES
Menendez, Pablo, Bueno, Clara, Barrera, Susana, Bataller, Alex, Ortiz-Maldonado, Valentín, Elliot, Natalina, O'Byrne, Sorcha, Wang, Gualing, Rovira, Montse, Gutierrez-Agüera, Francisco, Trincado, Juan, Gonzalez-Gonzalez, María, Morgades, Mireia, Sorigue, Marc, Barcena, Paloma, Zanetti, Samanta, Torrebadell, Montse, Vega, Nerea, Rives, Susana, Mallo, Mar, Sole, Francesc, Mead, Adam, Roberts, Irene, Thongjuea, Supat, Psaila, Bethan, Juan, Manel, Delgado, Julio, Urbano-Ispizúa, Alvaro, Ribera, Jose, Orfao, Alberto, Roy, Anindita, Menendez, Pablo
Published in Experimental hematology (2022)
Published in Experimental hematology (2022)
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Journal Article
High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans
Roy, Anindita, Bystry, Vojtech, Bohn, Georg, Goudevenou, Katerina, Reigl, Tomas, Papaioannou, Maria, Krejci, Adam, O'Byrne, Sorcha, Chaidos, Aristeidis, Grioni, Andrea, Darzentas, Nikos, Roberts, Irene A.G., Karadimitris, Anastasios
Published in Clinical immunology (Orlando, Fla.) (01.10.2017)
Published in Clinical immunology (Orlando, Fla.) (01.10.2017)
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Journal Article
High Resolution Igh Repertoire Analysis Reveals the Human Fetal Liver As the Origin of Life-Long, Innate B Lymphopoiesis
Roy, Anindita, Bystry, Vojtech, Bohn, Georg, Goudevenou, Katerina, Reigl, Tomas, Papaioannou, Maria, Krejci, Adam, O'Byrne, Sorcha, Chaidos, Aristeidis, Grioni, Andrea, Darzentas, Nikos, Roberts, Irene, Karadimitris, Anastasios
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway
Sng, Christopher C.T., O'Byrne, Sorcha, Prigozhin, Daniil M., Bauer, Matthias R., Harvey, Jennifer C., Ruhle, Michelle, Challis, Ben G., Lear, Sara, Roberts, Lee D., Workman, Sarita, Janowitz, Tobias, Magiera, Lukasz, Doffinger, Rainer, Buckland, Matthew S., Jodrell, Duncan J., Semple, Robert K., Wilson, Timothy J., Modis, Yorgo, Thaventhiran, James E.D.
Published in Journal of allergy and clinical immunology (01.07.2018)
Published in Journal of allergy and clinical immunology (01.07.2018)
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Journal Article
High resolution IgH repertoire analysis reveals fetal liver as the origin of life-long, innate B lymphopoiesis in humans
Roy, Anindita, Bystry, Vojtech, Bohn, Georg, Goudevenou, Katerina, Reigl, Tomas, Papaioannou, Maria, Krejci, Adam, O'Byrne, Sorcha, Chaidos, Aristeidis, Grioni, Andrea, Darzentas, Nikos, Roberts, Irene A.G, Karadimitris, Anastasios
Published in Clinical immunology (Orlando, Fla.) (2016)
Published in Clinical immunology (Orlando, Fla.) (2016)
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Journal Article
Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia
Louka, Eleni, Povinelli, Benjamin, Rodriguez-Meira, Alba, Buck, Gemma, Hamblin, Angela, Booth, Christopher, Roy, Anindita, Elliott, Natalina, Iskander, Deena, de la Fuente, Josu, Fordham, Nicholas James, Obyrne, Sorcha Isabella, Inglott, Sarah, Rao, Anupama Gopala, Roberts, Irene, Mead, Adam J
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
Louka, Eleni, Povinelli, Benjamin, Alba Rodriguez Meira, Buck, Gemma, Ashley, Neil, Hamblin, Angela, Booth, Christopher Ag, Sousos, Nikolaos, Roy, Anindita, Elliott, Natalina, Iskander, Deena, Josu De La Fuente, dham, Nicholas, O'byrne, Sorcha, Inglott, Sarah, Rao, Anupama, Roberts, Irene, Mead, Adam
Published in bioRxiv (07.05.2019)
Published in bioRxiv (07.05.2019)
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