Ketoreductase-Mediated Stereodivergent Synthesis of 1,1-Disubstituted Cyclobutan-3-ols
O’Dowd, Hardwin, Morales, Olivia M.
Published in Organic process research & development (19.07.2024)
Published in Organic process research & development (19.07.2024)
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Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives
O’Dowd, Hardwin, Manske, Jenna L., Freedman, Seth A., Cochran, John E.
Published in Organic letters (13.05.2022)
Published in Organic letters (13.05.2022)
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Second-Generation Antibacterial Benzimidazole Ureas: Discovery of a Preclinical Candidate with Reduced Metabolic Liability
Grillot, Anne-Laure, Tiran, Arnaud Le, Shannon, Dean, Krueger, Elaine, Liao, Yusheng, O’Dowd, Hardwin, Tang, Qing, Ronkin, Steve, Wang, Tiansheng, Waal, Nathan, Li, Pan, Lauffer, David, Sizensky, Emmanuelle, Tanoury, Jerry, Perola, Emanuele, Grossman, Trudy H, Doyle, Tim, Hanzelka, Brian, Jones, Steven, Dixit, Vaishali, Ewing, Nigel, Liao, Shengkai, Boucher, Brian, Jacobs, Marc, Bennani, Youssef, Charifson, Paul S
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Antimalarial, Antiproliferative, and Antitumor Activities of Artemisinin-Derived, Chemically Robust, Trioxane Dimers
Posner, Gary H, Ploypradith, Poonsakdi, Parker, Michael H, O'Dowd, Hardwin, Woo, Soon-Hyung, Northrop, John, Krasavin, Mikhail, Dolan, Patrick, Kensler, Thomas W, Xie, Suji, Shapiro, Theresa A
Published in Journal of medicinal chemistry (21.10.1999)
Published in Journal of medicinal chemistry (21.10.1999)
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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1
Boyd, Michael J, Collier, Philip N, Clark, Michael P, Deng, Hongbo, Kesavan, Sarathy, Ronkin, Steven M, Waal, Nathan, Wang, Jian, Cao, Jingrong, Li, Pan, Come, Jon, Davies, Ioana, Duffy, John P, Cochran, John E, Court, John J, Chandupatla, Kishan, Jackson, Katrina L, Maltais, Francois, O’Dowd, Hardwin, Boucher, Christina, Considine, Tony, Taylor, William P, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Crawford, Dan, Doyle, Elizabeth, Phillips, Jonathan, Kemper, Raymond, Swett, Rebecca, Empfield, James, Bunnage, Mark E, Charifson, Paul S, Magavi, Sanjay Shivayogi
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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N- and C-terminal modifications of negamycin
Raju, B, Mortell, Kathleen, Anandan, Sampathkumar, O'Dowd, Hardwin, Gao, Hongwu, Gomez, Marcela, Hackbarth, Corinne, Wu, Charlotte, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim, Patel, Dinesh V
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1
Come, Jon H, Senter, Timothy J, Clark, Michael P, Court, John J, Gale-Day, Zachary, Gu, Wenxin, Krueger, Elaine, Liang, Jianglin, Morris, Mark, Nanthakumar, Suganthini, O’Dowd, Hardwin, Maltais, Francois, Iyer, Ganesh, Andreassi, John, Boucher, Christina, Considine, Tony, Moody, Cameron S, Taylor, William, Mohanty, Arun K, Huang, Yulin, Zuccola, Harmon, Coll, Joyce, Bonanno, Kenneth C, Gagnon, Kevin J, Gan, Lu, Lu, Fan, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Song, Bin, Crawford, Dan, Doyle, Elisabeth, Kramer, Tal, Vought, Bryan, Phillips, Jonathan, Kemper, Raymond, Sanders, Martin, Swett, Rebecca, Furey, Brinley, Winquist, Ray, Bunnage, Mark E, Jackson, Katrina L, Charifson, Paul S, Magavi, Sanjay S
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Journal Article
Synthesis of a 6‑Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3‑Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization
Collier, Philip N, Panchagnula, Advaita, O’Dowd, Hardwin, Le Tiran, Arnaud, Aronov, Alex M
Published in ACS medicinal chemistry letters (10.01.2019)
Published in ACS medicinal chemistry letters (10.01.2019)
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Journal Article
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
Wang, Tiansheng, Duncan, Leonard, Gu, Wenxin, O’Dowd, Hardwin, Wei, Yunyi, Perola, Emanuele, Parsons, Jonathan, Gross, Christian H., Moody, Cameron Stuver, Ryan Arends, S.J., Charifson, Paul S.
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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An Asymmetric Synthesis of (2S,5S)-5-Substituted Azepane-2-Carboxylate Derivatives
Wishka, Donn G, Bédard, Marion, Brighty, Katherine E, Buzon, Richard A, Farley, Kathleen A, Fichtner, Michael W, Kauffman, Goss S, Kooistra, Jaap, Lewis, Jason G, O’Dowd, Hardwin, Samardjiev, Ivan J, Samas, Brian, Yalamanchi, Geeta, Noe, Mark C
Published in Journal of organic chemistry (18.03.2011)
Published in Journal of organic chemistry (18.03.2011)
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Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV
O’Dowd, Hardwin, Shannon, Dean E, Chandupatla, Kishan R, Dixit, Vaishali, Engtrakul, Juntyma J, Ye, Zhengqi, Jones, Steven M, O’Brien, Colleen F, Nicolau, David P, Tessier, Pamela R, Crandon, Jared L, Song, Bin, Macikenas, Dainius, Hanzelka, Brian L, Le Tiran, Arnaud, Bennani, Youssef L, Charifson, Paul S, Grillot, Anne-Laure
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Enantioselective Synthesis of N1999A2
Ji, Nan, O'Dowd, Hardwin, Rosen, Brad M, Myers, Andrew G
Published in Journal of the American Chemical Society (22.11.2006)
Published in Journal of the American Chemical Society (22.11.2006)
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Novel antibacterial azetidine lincosamides
O’Dowd, Hardwin, Lewis, Jason G., Trias, Joaquim, Asano, Rumi, Blais, Johanne, Lopez, Sara L., Park, Craig K., Wu, Charlotte, Wang, Wen, Gordeev, Mikhail F.
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Preparation of tetra-Boc-protected polymyxin B nonapeptide
O’Dowd, Hardwin, Kim, Bum, Margolis, Peter, Wang, Wen, Wu, Charlotte, Lopez, Sara L., Blais, Johanne
Published in Tetrahedron letters (12.03.2007)
Published in Tetrahedron letters (12.03.2007)
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APOL1 억제제 및 사용 방법
BRODNEY MICHAEL AARON, STONE STEVEN DAVID, SENTER TIMOTHY J, CAO JINGRONG, DAKIN LESLIE A, COCHRAN JOHN E, MAXWELL BRAD D, ANGLE SAMANTHA, SHIMIZU AKIRA JOSEPH, AHN JUN MYUN, DOLGIKH ELENA, O'DOWD HARDWIN, COME JON H, OLSEN JESSICA HOWARD, NANTHAKUMAR SUGANTHINI S, WANG HAOXUAN
Year of Publication 28.04.2023
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Year of Publication 28.04.2023
Patent
ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
DUFFY ERIN M, LOU RONGLIANG, WIMBERLY BRIAN T, BHATTACHARJEE ASHOKE, O'DOWD HARDWIN, CHEN SHILI, DEVIVO MARCO
Year of Publication 16.05.2018
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Year of Publication 16.05.2018
Patent
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part II: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
TIANSHENG WANG, DUNCAN, Leonard, CHARIFSON, Paul S, WENXIN GU, O'DOWD, Hardwin, YUNYI WEI, PEROLA, Emanuele, PARSONS, Jonathan, GROSS, Christian H, CAMERON STUVER MOODY, RYAN ARENDS, S. J
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
Published in Bioorganic & medicinal chemistry letters (01.06.2012)
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