High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry
O'Connor, Desmond, Mortishire-Smith, Russell
Published in Analytical and bioanalytical chemistry (01.05.2006)
Published in Analytical and bioanalytical chemistry (01.05.2006)
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Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham C., Budd, Emma, Cox, Brian, Cuenoud, Bernard, Finan, Peter, Gedeck, Peter, Hatto, Julia, Hayler, Judy F., Head, Denise, Keller, Thomas, Kirman, Louise, Leblanc, Catherine, Grand, Darren Le, McCarthy, Clive, O’Connor, Desmond, Owen, Charles, Oza, Mrinalini S., Pilgrim, Gaynor, Press, Nicola E., Sviridenko, Lilya, Whitehead, Lewis
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition
Ellard, John M., Madin, Andrew, Philps, Oliver, Hopkin, Mark, Henderson, Scott, Birch, Louise, O’Connor, Desmond, Arai, Tohru, Takase, Kazuma, Morgan, Louise, Reynolds, David, Talma, Sonia, Howley, Eimear, Powney, Ben, Payne, Andrew H., Hall, Adrian, Gartlon, Jane E., Dawson, Lee A., Castro, Luis, Atkinson, Peter J.
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Non-basic ligands for aminergic GPCRs: The discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders
Ladduwahetty, Tammy, Gilligan, Myra, Humphries, Alexander, Merchant, Kevin J., Fish, Rebecca, McAlister, George, Ivarsson, Magnus, Dominguez, Maria, O’Connor, Desmond, MacLeod, Angus M.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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2,5-Disubstituted pyridines : The discovery of a novel series of 5-HT2A ligands
WILSON, Kevin J, VAN NIEL, Monique B, COOPER, Laura, BLOOMFIELD, Dawn, O'CONNOR, Desmond, FISH, L. Rebecca, MACLEOD, Angus M
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
Published in Bioorganic & medicinal chemistry letters (01.05.2007)
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Human pharmacokinetics of XBD173 and etifoxine distinguish their potential for pharmacodynamic effects mediated by translocator protein
Owen, David R., Phillips, Alexandra, O’Connor, Desmond, Grey, Gabrielle, Aimola, Lina, Nicholas, Richard, Matthews, Paul M.
Published in British journal of clinical pharmacology (01.09.2022)
Published in British journal of clinical pharmacology (01.09.2022)
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Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABAA α5 inverse agonist for cognitive dysfunction
Jones, Philip, Atack, John R., Braun, Matthew P., Cato, Brian P., Chambers, Mark S., O’Connor, Desmond, Cook, Susan M., Hobbs, Sarah C., Maxey, Robert, Szekeres, Helen J., Szeto, Nicola, Wafford, Keith A., MacLeod, Angus M.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia
Fish, L Rebecca, Gilligan, Myra T, Humphries, Alexander C, Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J, O'Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M, Hutson, Peter H, MacLeod, Angus M
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
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'All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
Wrona, Mark, Mauriala, Timo, Bateman, Kevin P., Mortishire-Smith, Russell J., O'Connor, Desmond
Published in Rapid communications in mass spectrometry (01.01.2005)
Published in Rapid communications in mass spectrometry (01.01.2005)
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Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data
O'Connor, Desmond, Mortishire-Smith, Russell, Morrison, Denise, Davies, Amy, Dominguez, Maria
Published in Rapid communications in mass spectrometry (15.03.2006)
Published in Rapid communications in mass spectrometry (15.03.2006)
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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-alpha]phthalazines and analogues: High-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1
Carling, RW, Moore, KW, Street, LJ, Wild, D, Isted, C, Leeson, PD, Thomas, S, O'Connor, D, McKernan, RM, Quirk, K, Cook, SM, Atack, Wafford, KA, Thompson, SA, Dawson, GR, Ferris, P, Castro, JL
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Standards for nanosecond fluorescence decay time measurements
Lampert, Roger A, Chewter, Leslie A, Phillips, David, O'Connor, Desmond V, Roberts, Anthony J, Meech, Stephen R
Published in Analytical chemistry (Washington) (01.01.1983)
Published in Analytical chemistry (Washington) (01.01.1983)
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Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
Mortishire-Smith, Russell J., O'Connor, Desmond, Castro-Perez, Jose M., Kirby, Jane
Published in Rapid communications in mass spectrometry (01.01.2005)
Published in Rapid communications in mass spectrometry (01.01.2005)
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3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1
Carling, Robert W, Moore, Kevin W, Street, Leslie J, Wild, Deborah, Isted, Catherine, Leeson, Paul D, Thomas, Steven, O'Connor, Desmond, McKernan, Ruth M, Quirk, Katherine, Cook, Susan M, Atack, John R, Wafford, Keith A, Thompson, Sally A, Dawson, Gerard R, Ferris, Pushpinder, Castro, José L
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties
Chambers, Mark S, Atack, John R, Carling, Robert W, Collinson, Neil, Cook, Susan M, Dawson, Gerard R, Ferris, Pushpindar, Hobbs, Sarah C, O'Connor, Desmond, Marshall, George, Rycroft, W, MacLeod, Angus M
Published in Journal of medicinal chemistry (18.11.2004)
Published in Journal of medicinal chemistry (18.11.2004)
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Journal Article
Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers
Sternfeld, Francine, Carling, Robert W, Jelley, Richard A, Ladduwahetty, Tamara, Merchant, Kevin J, Moore, Kevin W, Reeve, Austin J, Street, Leslie J, O'Connor, Desmond, Sohal, Bindi, Atack, John R, Cook, Susan, Seabrook, Guy, Wafford, Keith, Tattersall, F. David, Collinson, Neil, Dawson, Gerard R, Castro, José L, MacLeod, Angus M
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists
Rowley, Michael, Hallett, David J, Goodacre, Simon, Moyes, Christopher, Crawforth, James, Sparey, Timothy J, Patel, Smita, Marwood, Rose, Patel, Shil, Thomas, Steven, Hitzel, Laure, O'Connor, Desmond, Szeto, Nicola, Castro, Jose L, Hutson, Peter H, MacLeod, Angus M
Published in Journal of medicinal chemistry (10.05.2001)
Published in Journal of medicinal chemistry (10.05.2001)
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