RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists
Bley, Keith R, Bhattacharya, Anindya, Daniels, Don V, Gever, Joel, Jahangir, Alam, O'Yang, Counde, Smith, Steven, Srinivasan, Dinesh, Ford, Anthony P D W, Jett, Mary‐Frances
Published in British journal of pharmacology (01.02.2006)
Published in British journal of pharmacology (01.02.2006)
Get full text
Journal Article
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
Qi, Wei, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Man, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chan, HoMan, Chen, Zijun, Fang, Douglas, Fei, Qi, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Li, Guobin, Lingel, Andreas, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter, Li, En
Published in Nature chemical biology (01.04.2017)
Published in Nature chemical biology (01.04.2017)
Get full text
Journal Article
Convenient Method for the 3-Functionalization of Isoindazoles
Bunnell, Aaron, O'Yang, Counde, Petrica, Andra, Soth, Michael J.
Published in Synthetic communications (01.01.2006)
Published in Synthetic communications (01.01.2006)
Get full text
Journal Article
Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain
Senisterra, Guillermo, Zhu, Hugh Y., Luo, Xiao, Zhang, Hailong, Xun, Guoliang, Lu, Chunliang, Xiao, Wen, Hajian, Taraneh, Loppnau, Peter, Chau, Irene, Li, Fengling, Allali-Hassani, Abdellah, Atadja, Peter, Oyang, Counde, Li, En, Brown, Peter J., Arrowsmith, Cheryl H., Zhao, Kehao, Yu, Zhengtian, Vedadi, Masoud
Published in SLAS discovery (01.10.2018)
Published in SLAS discovery (01.10.2018)
Get full text
Journal Article
Synthesis of 10,10-difluorothromboxane A2, a potent and chemically stable thromboxane agonist
Fried, Josef, John, Varghese, Szwedo, Mitchell J, Chen, Chien Kuang, O'Yang, Counde, Morinelli, Thomas A, Okwu, Anselm K, Halushka, Perry V
Published in Journal of the American Chemical Society (01.06.1989)
Published in Journal of the American Chemical Society (01.06.1989)
Get full text
Journal Article
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
Huang, Ying, Zhang, Jeff, Yu, Zhengtian, Zhang, Hailong, Wang, Youzhen, Lingel, Andreas, Qi, Wei, Gu, Justin, Zhao, Kehao, Shultz, Michael D, Wang, Long, Fu, Xingnian, Sun, Yongfeng, Zhang, Qiong, Jiang, Xiangqing, Zhang, Jiangwei, Zhang, Chunye, Li, Ling, Zeng, Jue, Feng, Lijian, Zhang, Chao, Liu, Yueqin, Zhang, Man, Zhang, Lijun, Zhao, Mengxi, Gao, Zhenting, Liu, Xianghui, Fang, Douglas, Guo, Haibing, Mi, Yuan, Gabriel, Tobias, Dillon, Michael P, Atadja, Peter, Oyang, Counde
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
Get full text
Journal Article
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies
Huang, Ying, Sendzik, Martin, Zhang, Jeff, Gao, Zhenting, Sun, Yongfeng, Wang, Long, Gu, Justin, Zhao, Kehao, Yu, Zhengtian, Zhang, Lijun, Zhang, Qiong, Blanz, Joachim, Chen, Zijun, Dubost, Valérie, Fang, Douglas, Feng, Lijian, Fu, Xingnian, Kiffe, Michael, Li, Ling, Luo, Fangjun, Luo, Xiao, Mi, Yuan, Mistry, Prakash, Pearson, David, Piaia, Alessandro, Scheufler, Clemens, Terranova, Remi, Weiss, Andreas, Zeng, Jue, Zhang, Hailong, Zhang, Jiangwei, Zhao, Mengxi, Dillon, Michael P, Jeay, Sebastien, Qi, Wei, Moggs, Jonathan, Pissot-Soldermann, Carole, Li, En, Atadja, Peter, Lingel, Andreas, Oyang, Counde
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
Get full text
Journal Article
Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment
Zhang, Ji Yue (Jeff), Zhang, Jiangwei, Kiffe, Michael, Walles, Markus, Jin, Yi, Blanz, Joachim, Dayer, Jerôme, Sanchez, Arevalo, Zhang, Chunye, Zhang, Lijun, Huang, Ying, Oyang, Counde
Published in Xenobiotica (02.01.2022)
Published in Xenobiotica (02.01.2022)
Get full text
Journal Article