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GP2017-HCF, a high concentration formulation, demonstrates similar pharmacokinetics, immunogenicity and safety to GP2017, an approved adalimumab biosimilar
von Richter, Oliver, O'Reilly, Terry, Guerrieri, Davide, Fan, Jamie, Fey, Constanze, Schussler, Steven, Furlan, Fabricio, Lemke, Lena
Published in Expert opinion on biological therapy (03.08.2023)
Published in Expert opinion on biological therapy (03.08.2023)
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Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults
Kavoosi, Mojgan, O’Reilly, Terry E., Kavoosi, Mehran, Chai, Peng, Engel, Caroline, Korz, Walter, Gallen, Christopher C., Lester, Robert M.
Published in Toxins (09.08.2020)
Published in Toxins (09.08.2020)
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Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK
Nguyen, Linh, Holland, Jaymes, Miles, Dale, Engel, Caroline, Benrimoh, Natacha, O'Reilly, Terry, Lacy, Steven
Published in Journal of clinical pharmacology (01.09.2015)
Published in Journal of clinical pharmacology (01.09.2015)
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SAFETY OF AMISELIMOD IN HEALTHY SUBJECTS: RESULTS FROM A PHASE 1 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
Hanauer, Stephen, O’Reilly, Terry, Lester, Robert, Slatkin, Neal, Lee, Jimin, Franklin, Howard, Bulawski, Angela, Israel, Robert
Published in Inflammatory bowel diseases (21.01.2021)
Published in Inflammatory bowel diseases (21.01.2021)
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Effect of letermovir on levonorgestrel and ethinyl estradiol pharmacokinetics
Adedoyin, Adedayo, Cho, Carolyn R., Fox-Bosetti, Sabrina, Macha, Sreeraj, Zhao, Tian, Liu, Fang, Panebianco, Deborah, O’Reilly, Terry E., McCrea, Jacqueline, Stoch, S. Aubrey, Iwamoto, Marian
Published in International journal of clinical pharmacology and therapeutics (01.09.2019)
Published in International journal of clinical pharmacology and therapeutics (01.09.2019)
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P029 Pharmacokinetic/Pharmacodynamic Analysis of Amiselimod, a Selective Sphingosine 1-Phosphate Receptor Modulator, in Healthy Subjects: Results From a Phase 1 Study
Lee, Jimin, Lester, Robert, O'Reilly, Terry, Lowe, Ezra, Slatkin, Neal, Franklin, Howard, Israel, Robert
Published in The American journal of gastroenterology (01.12.2021)
Published in The American journal of gastroenterology (01.12.2021)
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A thorough QTc study demonstrates that olmesartan medoxomil does not prolong the QTc interval
Mendell, Jeanne, Matsushima, Nobuko, O'Reilly, Terry E., Lee, James
Published in Journal of clinical pharmacology (01.04.2016)
Published in Journal of clinical pharmacology (01.04.2016)
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No clinically meaningful pharmacokinetic interaction between the hepatitis C virus inhibitors elbasvir and grazoprevir and the oral contraceptives ethinyl estradiol and levonorgestrel
Marshall, William L., Feng, Hwa-Ping, Caro, Luzelena, Talaty, Jennifer, Guo, Zifang, Huang, Xiaobi, Panebianco, Deborah, Ma, Joanne, Mangin, Eric, O’Reilly, Terry E., Butterton, Joan R., Yeh, Wendy W.
Published in European journal of clinical pharmacology (01.05.2017)
Published in European journal of clinical pharmacology (01.05.2017)
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P014 Analysis of QT Interval Prolongation of Amiselimod in Healthy Subjects: A Phase 1 Randomized Controlled Trial
Stephen, Hanauer, Terry, O'Reilly, Robert, Lester, Neal, Slatkin, Jimin, Lee, Howard, Franklin, Angela, Bulawski, Robert, Israel
Published in The American journal of gastroenterology (01.12.2020)
Published in The American journal of gastroenterology (01.12.2020)
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Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models
Becquet, Mike, Laborde, Laurent, Texier, Celine, Sterker, Dario, Gschwind, Hans-Peter, Pfaar, Ulrike, Wartmann, Markus, O'Reilly, Terry M, McSheehy, Paul M
Published in Anti-cancer drugs (01.08.2018)
Published in Anti-cancer drugs (01.08.2018)
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First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers
Fox, Jonathan C., Hellawell, Jennifer L., Rao, Satish, O'Reilly, Terry, Lumpkin, Rick, Jernelius, Jesper, Gretler, Daniel, Sinha, Uma
Published in Clinical pharmacology in drug development (01.01.2020)
Published in Clinical pharmacology in drug development (01.01.2020)
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Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo
O'Reilly, Terry, McSheehy, Paul M J, Wartmann, Markus, Lassota, Peter, Brandt, Ralf, Lane, Heidi A
Published in Anti-cancer drugs (01.01.2011)
Published in Anti-cancer drugs (01.01.2011)
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Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind, placebo-controlled, dose-ranging trial
Robbins, Jonathan A., Tait, Dereck, Huang, Qinlei, Dubey, Sheri, Crumley, Tami, Cote, Josee, Luk, Julie, Sachs, Jeffrey R., Rutkowski, Kathryn, Park, Harriet, Schwab, Robert, Howitt, William Joseph, Rondon, Juan Carlos, Hernandez-Illas, Martha, O'Reilly, Terry, Smith, William, Simon, Jakub, Hardalo, Cathy, Zhao, Xuemei, Wnek, Richard, Cope, Alethea, Lai, Eseng, Annunziato, Paula, Guris, Dalya, Stoch, S. Aubrey
Published in EBioMedicine (01.08.2022)
Published in EBioMedicine (01.08.2022)
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2389. Effect of Rezafungin on QT Interval in Healthy Subjects
Flanagan, Shawn, Goodman, Daniel B, Rao, Pallavi, Jandourek, Alena, O’Reilly, Terry, Sandison, Taylor
Published in Open forum infectious diseases (26.11.2018)
Published in Open forum infectious diseases (26.11.2018)
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Thorough QTc Study of a Single Supratherapeutic Dose of Relebactam in Healthy Participants
Boundy, Keith, Liu, Yang, Bhagunde, Pratik, O'Reilly, Terry E., Colon‐Gonzalez, Francheska, Friedman, Evan J., Lala, Mallika, Rhee, Elizabeth G., Rizk, Matthew L.
Published in Clinical pharmacology in drug development (01.05.2020)
Published in Clinical pharmacology in drug development (01.05.2020)
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Pharmacokinetic and pharmacodynamic interactions between the hepatitis C virus protease inhibitor, boceprevir, and the oral contraceptive ethinyl estradiol/norethindrone
Lin, Wen H., Feng, Hwa-Ping, Shadle, Craig R., O’Reilly, Terry, Wagner, John A., Butterton, Joan R.
Published in European journal of clinical pharmacology (01.09.2014)
Published in European journal of clinical pharmacology (01.09.2014)
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P029 Pharmacokinetic/Pharmacodynamic Analysis of Amiselimod, a Selective Sphingosine 1-Phosphate Receptor Modulator, in Healthy Subjects: Results From a Phase 1 Study
Lee, Jimin, Lester, Robert, O'Reilly, Terry, Lowe, Ezra, Slatkin, Neal, Franklin, Howard, Israel, Robert
Published in The American journal of gastroenterology (01.12.2021)
Published in The American journal of gastroenterology (01.12.2021)
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Thorough QT/QTc study to evaluate the effect of a single supratherapeutic dose of islatravir on QTc interval prolongation in healthy adults
Matthews, Randolph P., Liu, Yang, Matthews, Catherine, Butterfield, Kristin L., O'Reilly, Terry, Stoch, S. Aubrey, Iwamoto, Marian
Published in Antimicrobial agents and chemotherapy (07.08.2024)
Published in Antimicrobial agents and chemotherapy (07.08.2024)
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Inhibition of fatty acid synthase with FT‐4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non‐alcoholic fatty liver disease: Results from two early‐phase randomized trials
Beysen, Carine, Schroeder, Patricia, Wu, Eric, Brevard, Julie, Ribadeneira, Maria, Lu, Wei, Dole, Kiran, O'Reilly, Terry, Morrow, Linda, Hompesch, Marcus, Hellerstein, Marc K., Li, Kelvin, Johansson, Lars, Kelly, Patrick F.
Published in Diabetes, obesity & metabolism (01.03.2021)
Published in Diabetes, obesity & metabolism (01.03.2021)
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SAFETY OF AMISELIMOD IN HEALTHY SUBJECTS: RESULTS FROM A PHASE 1 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
Hanauer, Stephen, O’Reilly, Terry, Lester, Robert, Slatkin, Neal, Lee, Jimin, Franklin, Howard, Bulawski, Angela, Israel, Robert
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2021)
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