Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78
Kotecha, Minal, Kluza, Jerome, Wells, Geoff, O'Hare, C Caroline, Forni, Claudia, Mantovani, Roberto, Howard, Philip W, Morris, Peter, Thurston, David E, Hartley, John A, Hochhauser, Daniel
Published in Molecular cancer therapeutics (01.05.2008)
Published in Molecular cancer therapeutics (01.05.2008)
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Journal Article
Sequence Recognition in the Minor Groove of DNA by Covalently Linked Formamido Imidazole−Pyrrole−Imidazole Polyamides: Effect of H-Pin Linkage and Linker Length on Selectivity and Affinity
O'Hare, C. Caroline, Uthe, Peter, Mackay, Hilary, Blackmon, Kevin, Jones, Justin, Brown, Toni, Nguyen, Binh, Wilson, W. David, Lee, Moses, Hartley, John A
Published in Biochemistry (Easton) (23.10.2007)
Published in Biochemistry (Easton) (23.10.2007)
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Journal Article
Synthesis of novel DNA cross-linking antitumour agents based on polyazamacrocycles
Parker, Laurie L., Anderson, Fiona M., O’Hare, C. Caroline, Lacy, Stephen M., Bingham, John P., Robins, David J., Hartley, John A.
Published in Bioorganic & medicinal chemistry (01.04.2005)
Published in Bioorganic & medicinal chemistry (01.04.2005)
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Journal Article
DNA Sequence Recognition in the Minor Groove by Crosslinked Polyamides: The Effect of N-Terminal Head Group and Linker Length on Binding Affinity and Specificity
O'Hare, C. Caroline, Mack, Darcy, Tandon, Manju, Sharma, Sanjay K., Lown, J. William, Kopka, Mary L., Dickerson, Richard E., Hartley, John A.
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
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Journal Article
A Novel Design Strategy for Stable Metal Complexes of Nitrogen Mustards as Bioreductive Prodrugs
Parker, Laurie L, Lacy, Stephen M, Farrugia, Louis J, Evans, Cameron, Robins, David J, O'Hare, C. Caroline, Hartley, John A, Jaffar, Mohammed, Stratford, Ian J
Published in Journal of medicinal chemistry (04.11.2004)
Published in Journal of medicinal chemistry (04.11.2004)
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Journal Article
A Monofunctional Derivative of Melphalan: Preparation, DNA Alkylation Products, and Determination of the Specificity of Monoclonal Antibodies That Recognize Melphalan−DNA Adducts
Tilby, Michael J, McCartney, Hazel, Gould, Katherine A, O'Hare, C. Caroline, Hartley, John A, Hall, Andrew G, Golding, Bernard T, Lawley, Philip D
Published in Chemical research in toxicology (01.10.1998)
Published in Chemical research in toxicology (01.10.1998)
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Journal Article
Cross-Linking and Sequence Specific Alkylation of DNA by Aziridinyl Quinones. 2. Structure Requirements for Sequence Selectivity
Hargreaves, Rob H. J, Mayalarp, Stephen P, Butler, John, McAdam, Simon R, O'Hare, C. Caroline, Hartley, John A
Published in Journal of medicinal chemistry (31.01.1997)
Published in Journal of medicinal chemistry (31.01.1997)
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Journal Article
Synthesis of new homochiral bispyrrolidines as potential DNA cross-linking antitumour agents
Anderson, F M, O'Hare, C C, Hartley, J A, Robins, D J
Published in Anti-cancer drug design (01.04.2000)
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Published in Anti-cancer drug design (01.04.2000)
Journal Article
Synthesis of new bifunctional compounds which selectively alkylate guanines in DNA
Henderson, N D, Lacy, S M, O'Hare, C C, Hartley, J A, McClean, S, Wakelin, L P, Kelland, L R, Robins, D J
Published in Anti-cancer drug design (01.10.1998)
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Published in Anti-cancer drug design (01.10.1998)
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