Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing
Weng, Yan, Ishino, Tetsuya, Sievers, Annette, Talukdar, Saswata, Chabot, Jeffrey R., Tam, Amy, Duan, Weili, Kerns, Kelvin, Sousa, Eric, He, Tao, Logan, Alison, Lee, Darwin, Li, Dongmei, Zhou, Yingjiang, Bernardo, Barbara, Joyce, Alison, Kavosi, Mania, O’Hara, Denise M., Clark, Tracey, Guo, Jie, Giragossian, Craig, Stahl, Mark, Calle, Roberto A., Kriz, Ron, Somers, Will, Lin, Laura
Published in Scientific reports (09.03.2018)
Published in Scientific reports (09.03.2018)
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One Mouse, One Pharmacokinetic Profile: Quantitative Whole Blood Serial Sampling for Biotherapeutics
Joyce, Alison P., Wang, Mengmeng, Lawrence-Henderson, Rosemary, Filliettaz, Cynthia, Leung, Sheldon S., Xu, Xin, O’Hara, Denise M.
Published in Pharmaceutical research (01.07.2014)
Published in Pharmaceutical research (01.07.2014)
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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics
Avery, Lindsay B, Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S, Penn, Steve, Cirelli, David, Kurz, Jeffrey C, Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J, McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J, Lin, Laura, Bloom, Laird, O'Hara, Denise M
Published in mAbs (17.02.2018)
Published in mAbs (17.02.2018)
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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics
Piche-Nicholas, Nicole M, Avery, Lindsay B, King, Amy C, Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M, Tchistiakova, Lioudmila, Katragadda, Madan
Published in mAbs (01.01.2018)
Published in mAbs (01.01.2018)
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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies
Avery, Lindsay B, Wang, Mengmeng, Kavosi, Mania S, Joyce, Alison, Kurz, Jeffrey C, Fan, Yao-Yun, Dowty, Martin E, Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M, Neubert, Hendrik, Polzer, Robert J, O'Hara, Denise M
Published in mAbs (17.08.2016)
Published in mAbs (17.08.2016)
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Comparison of Succinimidyl [125I]Iodobenzoate with Iodogen Iodination Methods to Study Pharmacokinetics and ADME of Biotherapeutics
Chen, Jianqing, Wang, Mengmeng, Joyce, Alison, DeFranco, David, Kavosi, Mania, Xu, Xin, O’Hara, Denise M.
Published in Pharmaceutical research (01.10.2014)
Published in Pharmaceutical research (01.10.2014)
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Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics
Ishino, Tetsuya, Wang, Mengmeng, Mosyak, Lidia, Tam, Amy, Duan, Weili, Svenson, Kristine, Joyce, Alison, O'Hara, Denise M., Lin, Laura, Somers, William S., Kriz, Ronald
Published in The Journal of biological chemistry (07.06.2013)
Published in The Journal of biological chemistry (07.06.2013)
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Journal Article
Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice
Fan, Yao-Yun, Avery, Lindsay B., Wang, Mengmeng, O'Hara, Denise M., Leung, Sheldon, Neubert, Hendrik
Published in mAbs (03.07.2016)
Published in mAbs (03.07.2016)
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Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation
Wang, Mengmeng, Kussrow, Amanda K, Ocana, Mireia Fernandez, Chabot, Jeffrey R, Lepsy, Christopher S, Bornhop, Darryl J, O'Hara, Denise M
Published in British journal of pharmacology (01.01.2017)
Published in British journal of pharmacology (01.01.2017)
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Quantitative biodistribution of biotherapeutics at whole body, organ and cellular levels by autoradiography
Wang, Mengmeng, Zhan, Yutian, O'Neil, Shawn P, Harris, Stephen, Henson, Claire, McEwen, Andrew, Webster, Rob, O'Hara, Denise M
Published in Bioanalysis (01.09.2018)
Published in Bioanalysis (01.09.2018)
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Faster in vivo clearance of human embryonic kidney than Chinese hamster ovary cell derived protein: Role of glycan mediated clearance
Wang, Mengmeng, Ishino, Tetsuya, Joyce, Alison, Tam, Amy, Duan, Weili, Lin, Laura, Somers, William S., Kriz, Ronald, O'Hara, Denise M.
Published in Journal of bioscience and bioengineering (01.06.2015)
Published in Journal of bioscience and bioengineering (01.06.2015)
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Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy
Wang, Mengmeng, Zhan, Yutian, Chen, Jianqing, Rong, Haojing, O’Neil, Shawn P., Ghosh, Brahma, Nguyen, Vuong, Owens, Jane, Li, Xianfeng, O’Hara, Denise M.
Published in International Journal of Molecular Imaging (01.01.2016)
Published in International Journal of Molecular Imaging (01.01.2016)
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Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey
Catlin, Natasha R, Mitchell, Andrea Z, Potchoiba, Michael J, O'Hara, Denise M, Wang, Mengmeng, Zhang, Minlei, Weinbauer, Gerhard F, Bowman, Christopher J
Published in Birth defects research (01.01.2020)
Published in Birth defects research (01.01.2020)
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Journal Article
Human FcRn Tissue Expression Profile and Half-Life in PBMCs
Fan, Yao-Yun, Farrokhi, Vahid, Caiazzo, Teresa, Wang, Mengmeng, O'Hara, Denise M, Neubert, Hendrik
Published in Biomolecules (Basel, Switzerland) (15.08.2019)
Published in Biomolecules (Basel, Switzerland) (15.08.2019)
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Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents
O’Hara, Denise M., Theobald, Valerie, Egan, Adrienne Clements, Usansky, Joel, Krishna, Murli, TerWee, Julie, Maia, Mauricio, Spriggs, Frank P., Kenney, John, Safavi, Afshin, Keefe, Jeannine
Published in The AAPS journal (01.06.2012)
Published in The AAPS journal (01.06.2012)
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Bioanalytical platform comparison using a generic human IgG PK assay format
Leary, Beth A., Lawrence-Henderson, Rosemary, Mallozzi, Carolyn, Fernandez Ocaña, Mireia, Duriga, Nicole, O’Hara, Denise M., Kavosi, Mania, Qu, Qiang, Joyce, Alison P.
Published in Journal of immunological methods (29.11.2013)
Published in Journal of immunological methods (29.11.2013)
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Journal Article
Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
Whittemore, Lisa-Anne, Song, Kening, Li, Xiangping, Aghajanian, Jane, Davies, Monique, Girgenrath, Stefan, Hill, Jennifer J., Jalenak, Mary, Kelley, Pamela, Knight, Andrea, Maylor, Rich, O’Hara, Denise, Pearson, Adele, Quazi, Amira, Ryerson, Stephanie, Tan, Xiang-Yang, Tomkinson, Kathleen N., Veldman, Geertruida M., Widom, Angela, Wright, Jill F., Wudyka, Steve, Zhao, Liz, Wolfman, Neil M.
Published in Biochemical and biophysical research communications (24.01.2003)
Published in Biochemical and biophysical research communications (24.01.2003)
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