Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development
Page, Natalie, Wappett, Mark, O’Dowd, Colin R., O’Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy
Published in Scientific reports (20.09.2022)
Published in Scientific reports (20.09.2022)
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Journal Article
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors
O’Dowd, Colin R, Helm, Matthew D, Rountree, J. S. Shane, Flasz, Jakub T, Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R, Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Feutren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy
Published in ACS medicinal chemistry letters (08.03.2018)
Published in ACS medicinal chemistry letters (08.03.2018)
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Journal Article
Chemoenzymatic Synthesis of Carbasugars (+)-Pericosines A−C from Diverse Aromatic cis-Dihydrodiol Precursors
Boyd, Derek R, Sharma, Narain D, Acaru, Carmen A, Malone, John F, O’Dowd, Colin R, Allen, Christopher C. R, Stevenson, Paul J
Published in Organic letters (21.05.2010)
Published in Organic letters (21.05.2010)
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Journal Article
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Jurisic, Anamarija, Sung, Pei‐Ju, Wappett, Mark, Daubriac, Julien, Lobb, Ian T., Kung, Wei‐Wei, Crawford, Nyree, Page, Natalie, Cassidy, Eamon, Feutren‐Burton, Stephanie, Rountree, J. S. Shane, Helm, Matthew D., O'Dowd, Colin R., Kennedy, Richard D., Gavory, Gerald, Cranston, Aaron N., Longley, Daniel B., Jacq, Xavier, Harrison, Timothy
Published in Clinical and translational medicine (01.04.2024)
Published in Clinical and translational medicine (01.04.2024)
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Journal Article
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Gavory, Gerald, O'Dowd, Colin R, Helm, Matthew D, Flasz, Jakub, Arkoudis, Elias, Dossang, Anthony, Hughes, Caroline, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Barker, Oliver, Miel, Hugues, Harrison, Timothy
Published in Nature chemical biology (01.02.2018)
Published in Nature chemical biology (01.02.2018)
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Journal Article
cis-Dihydrodiol, arene oxide and phenol metabolites of dictamnine: key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids
Boyd, DR, Sharma, ND, O'Dowd, CR, Carroll, JG, Loke, PL, Allen, CCR
Published in Chemical communications (Cambridge, England) (21.08.2005)
Published in Chemical communications (Cambridge, England) (21.08.2005)
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Chemoenzymatic synthesis of the carbasugars carba-beta-L-galactopyranose, carba-beta-L-talopyranose and carba-alpha-L-talopyranose from methyl benzoate
Boyd, Derek R., Sharma, Narain D., Bowers, Nigel I., Coen, Gerard B., Malone, John F., O'Dowd, Colin R., Stevenson, Paul J., Allen, Christopher C. R.
Published in Organic & biomolecular chemistry (21.03.2010)
Published in Organic & biomolecular chemistry (21.03.2010)
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Journal Article
syn-Benzene dioxides: chemoenzymatic synthesis from 2,3-cis-dihydrodiol derivatives of monosubstituted benzenes and their application in the synthesis of regioisomeric 1,2-and 3,4-cis-dihydrodiols and 1,4-dioxocins
Boyd, Derek R., Sharma, Narain D., Llamas, Nuria M., O'Dowd, Colin R., Allen, Christopher C. R.
Published in Organic & biomolecular chemistry (01.01.2007)
Published in Organic & biomolecular chemistry (01.01.2007)
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Journal Article
Chemoenzymatic synthesis of the trans-dihydrodiol isomers of monosubstituted benzenes via anti-benzene dioxides
Boyd, Derek R., Sharma, Narain D., Llamas, Nuria M., O'Dowd, Colin R., Allen, Christopher C. R.
Published in Organic & biomolecular chemistry (07.06.2006)
Published in Organic & biomolecular chemistry (07.06.2006)
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Journal Article
Chemoenzymatic synthesis of carbasugars from iodobenzene
Boyd, DR, Sharma, ND, Llamas, NM, Malone, JF, O'Dowd, CR, Allen, CCR
Published in Organic & biomolecular chemistry (21.05.2005)
Published in Organic & biomolecular chemistry (21.05.2005)
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Journal Article
Abstract LB022: A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy
Page, Natalie, Karthikaisamy, Vignesh, O'Hara, Darren, Cranston, Aaron N., O'Dowd, Colin R., Jacq, Xavier, Wilkinson, Richard, Burton, Stephanie, Gibson, Hayley, Costa, Joana, Longley, Daniel, Helm, Matthew, McGivern, Chris, Shepherd, Steven, Bell, Christina, Hewitt, Peter, McFarland, Mary, Miel, Hugues, Whitehead, Steven, Proctor, Lauren, Rountree, Shane J., Wappett, Mark, Diaz, Mauricio Berriel, Herzig, Stephan, Harrison, Timothy
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
Biphenyl dioxygenase-catalysed cis-dihydroxylation of tricyclic azaarenes: chemoenzymatic synthesis of arene oxide metabolites and furoquinoline alkaloids
Boyd, Derek R., Sharma, Narain D., Carroll, Jonathan G., Loke, Pui L., O'Dowd, Colin R., Allen, Christopher C. R.
Published in RSC advances (2013)
Published in RSC advances (2013)
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Journal Article
cis-Dihydrodiol, Arene Oxide and Phenol Metabolites of Dictamnine: Key Intermediates in the Biodegradation and Biosynthesis of Furoquinoline Alkaloids
Boyd, Derek R., Sharma, Narain D., O'Dowd, Colin R., Carroll, Jonathan G., Loke, Pui L., Allen, Christopher C. R.
Published in ChemInform (20.12.2005)
Published in ChemInform (20.12.2005)
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