Optimised affinity purification of polyclonal antibodies from hyper immunised ovine serum using a synthetic Protein A adsorbent, MAbsorbent ® A2P
Newcombe, Anthony R., Cresswell, Chrissie, Davies, Susannah, Watson, Keith, Harris, Guy, O’Donovan, Kieran, Francis, Richard
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (25.01.2005)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (25.01.2005)
Get full text
Journal Article
Characterisation of an industrial affinity process used in the manufacturing of digoxin-specific polyclonal Fab fragments
Thillaivinayagalingam, Pranavan, O’Donovan, Kieran, Newcombe, Anthony R., Keshavarz-Moore, Eli
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.03.2007)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.03.2007)
Get full text
Journal Article
Evaluation of a biosensor assay to quantify polyclonal IgG in ovine serum used for the production of biotherapeutic antibody fragments
Newcombe, Anthony R., Cresswell, Chrissie, Davies, Susannah, Pearce, Felicity, O’Donovan, Kieran, Francis, Richard
Published in Process biochemistry (1991) (01.04.2006)
Published in Process biochemistry (1991) (01.04.2006)
Get full text
Journal Article
NVG-222: A First-in-Class Autoregulating Half-Life Extended ROR1xCD3 T Cell Engager Heralding a New Class of Safer Drugs
Granger, David, Muczynski, Vincent, Henne, Patricia, Baccaro, Annalisa, Fernando, Dinusha, Shah, Mittal, Devlin, John, O'Donovan, Kieran, Nathwani, Amit C.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
Pre-Clinical Development of a First in Class Half-Life Extended T Cell Engager Targeting ROR-1
Granger, David, Henne, Patricia, Baccaro, Annalisa, Fernando, Dinusha, Gore, Jasmine, Gbajumo, Ephraim, Muczynski, Vincent, Shah, Mittal, O'Donovan, Kieran, Chester, Kerry, Nathwani, Amit C.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
First-in-human phase I study of a ROR1-targeting bispecific T-cell engager (NVG-111) shows evidence of efficacy in patients with relapsed/refractory CLL and MCL
Jasani, Parag, Townsend, William, Asher, Samir, Tayabali, Sarrah, Tucker, David, Cook, Sarah, Batten, Toby, Granger, David, Shah, Mittal, O'Donovan, Kieran, Nathwani, Amit C.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
Get full text
Journal Article
The use of a transient transfected expression system to deliver high quality bispecific T-cell engager drug product, NVG-111, to the clinic for a fraction of the cost and time associated with the development and use of a producer cell line
O'Donovan, Kieran, Bhatt, Shivam, Baccaro, Annalisa, Fernando, Dinusha, Smith, Angel, Gbajumo, Ephraim, Bobrzynski, Tomasz, McIntosh, Jenny, Gore, Jasmine, Nathwani, Amit C., Chester, Kerry, Granger, David
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
Get full text
Journal Article
Activity and biophysical properties related to clinical evaluation of a first-in-class EHL ROR1xCD3 T Cell Engager
Granger, David, Bhatt, Shivam, Henne, Patricia, Baccaro, Annalisa, Fernando, Dinusha, Gore, Jasmine, Gbajumo, Ephraim, O'Donovan, Kieran, Chester, Kerry, Nathwani, Amit C.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
Get full text
Journal Article
A sensitive and robust bioanalytical assay for pharmacokinetic analysis of ROR1xCD3 bispecific T cell engager (NVG-111) in a first-in-human study
Shah, Mittal, Granger, David, Bobrzynski, Tomasz, Baccaro, Annalisa, Gore, Jasmine, Muczynski, Vincent, Cook, Sarah, Chester, Kerry, Batten, Toby, O'Donovan, Kieran, Jasani, Parag, Nathwani, Amit C.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
Get full text
Journal Article
Time Limited Exposure to a ROR1 Targeting Bispecific T Cell Engager (NVG-111) Leads to Durable Responses in Subjects with Relapsed Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)
Townsend, William, Leong, Sarah, Shah, Mittal, Batten, Toby, Tucker, David, Pottinger, Bryson, Paneesha, Shankaranarayana, El-Sharkawi, Dima, Eyre, Toby A., Lam, Ho Pui Jeff, Zheng, Jiexin, Cook, Sarah, Granger, David, Ahern, David, O'Donovan, Kieran, Nathwani, Amit C., Jasani, Parag
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
Get full text
Journal Article
First-in-Human Phase I Trial of a ROR1 Targeting Bispecific T Cell Engager (NVG-111) in Combination with Ibrutinib or As Monotherapy in Subjects with Relapsed Refractory Chronic Lymphocytic Leukaemia (CLL) and Mantle Cell Lymphoma (MCL)
Townsend, William, Leong, Sarah, Tucker, David, Pottinger, Bryson, Paneesha, Shankara, El-Sharkawi, Dima, Eyre, Toby A., Batten, Toby, Shah, Mittal, Cook, Sarah, Granger, David, O'Donovan, Kieran, Nathwani, Amit C., Jasani, Parag
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
NVG-111, a novel ROR1xCD3 bispecific antibody for non-Hodgkin lymphoma
Granger, David, Gohil, Satyen, Barbarulo, Alessandro, Baccaro, Annalisa, Muczynski, Vincent, Chester, Kerry, Germaschewski, Fiona, Batten, Toby, Brown, Kathryn, Cook, Sarah, O'Donovan, Kieran, Jasani, Parag, Nathwani, Amit C., Phillips, Peter
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
Get full text
Journal Article
Status, Trends and Attendance Patterns of the Northern Fulmar Fulmarus glacialis in Nunavut, Canada
Gaston, Anthony J., Mallory, Mark L., Gilchrist, H. Grant, O'Donovan, Kieran
Published in Arctic (18.12.2009)
Published in Arctic (18.12.2009)
Get full text
Journal Article
Status, Trends and Attendance Patterns of the Northern Fulmar Fulmarus glacialis in Nunavut, Canada
Gaston, Anthony J., Mallory, Mark L., Gilchrist, H. Grant, O'Donovan, Kieran
Published in Arctic (01.06.2006)
Get full text
Published in Arctic (01.06.2006)
Journal Article
The integrated simulation and assessment of the impacts of process change in biotherapeutic antibody production
CHHATRE, Sunil, JONES, Carl, FRANCIS, Richard, O'DONOVAN, Kieran, TITCHENER-HOOKER, Nigel, NEWCOMBE, Anthony, KESHAVARZ-MOORE, Eli
Published in Biotechnology progress (01.11.2006)
Published in Biotechnology progress (01.11.2006)
Get full text
Journal Article
The Integrated Simulation and Assessment of the Impacts of Process Change in Biotherapeutic Antibody Production
Chhatre, Sunil, Jones, Carl, Francis, Richard, O'Donovan, Kieran, Titchener-Hooker, Nigel, Newcombe, Anthony, Keshavarz-Moore, Eli
Published in Biotechnology progress (01.12.2006)
Published in Biotechnology progress (01.12.2006)
Get full text
Journal Article
Detection and quantification of affinity ligand leaching and specific antibody fragment concentration within chromatographic fractions using surface plasmon resonance
Thillaivinayagalingam, Pranavan, Newcombe, Anthony R, O'Donovan, Kieran, Francis, Richard, Keshavarz-Moore, Eli
Published in Biotechnology and applied biochemistry (01.12.2007)
Published in Biotechnology and applied biochemistry (01.12.2007)
Get more information
Journal Article
Optimal conditions for the papain digestion of polyclonal ovine IgG for the production of bio-therapeutic Fab fragments
Cresswell, Chrissie, Newcombe, Anthony R, Davies, Susannah, Macpherson, Ian, Nelson, Paul, O'Donovan, Kieran, Francis, Richard
Published in Biotechnology and applied biochemistry (01.10.2005)
Get more information
Published in Biotechnology and applied biochemistry (01.10.2005)
Journal Article