Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood
Li, Ke Sherry, Chu, Phillip Y., Fourie-O’Donohue, Aimee, Srikumar, Neha, Kozak, Katherine R., Liu, Yichin, Tran, John C.
Published in Journal of the American Society for Mass Spectrometry (01.07.2018)
Published in Journal of the American Society for Mass Spectrometry (01.07.2018)
Get full text
Journal Article
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates
Zhang, Donglu, Fourie-O'Donohue, Aimee, Dragovich, Peter S, Pillow, Thomas H, Sadowsky, Jack D, Kozak, Katherine R, Cass, Robert T, Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis E C A, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
Get full text
Journal Article
Attachment Site Cysteine Thiol pK a Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates
Vollmar, Breanna S, Wei, Binqing, Ohri, Rachana, Zhou, Jianhui, He, Jintang, Yu, Shang-Fan, Leipold, Douglas, Cosino, Ely, Yee, Sharon, Fourie-O’Donohue, Aimee, Li, Guangmin, Phillips, Gail L, Kozak, Katherine R, Kamath, Amrita, Xu, Keyang, Lee, Genee, Lazar, Greg A, Erickson, Hans K
Published in Bioconjugate chemistry (18.10.2017)
Published in Bioconjugate chemistry (18.10.2017)
Get full text
Journal Article
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer
Bhakta, Sunil, Crocker, Lisa M, Chen, Yvonne, Hazen, Meredith, Schutten, Melissa M, Li, Dongwei, Kuijl, Coenraad, Ohri, Rachana, Zhong, Fiona, Poon, Kirsten A, Go, Mary Ann T, Cheng, Eric, Piskol, Robert, Firestein, Ron, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Raab, Helga, Hongo, Jo-Anne, Sampath, Deepak, Dennis, Mark S, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R
Published in Molecular cancer therapeutics (01.03.2018)
Published in Molecular cancer therapeutics (01.03.2018)
Get full text
Journal Article
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
Sadowsky, Jack D, Pillow, Thomas H, Chen, Jinhua, Fan, Fang, He, Changrong, Wang, Yanli, Yan, Gang, Yao, Hui, Xu, Zijin, Martin, Shanique, Zhang, Donglu, Chu, Phillip, dela Cruz-Chuh, Josefa, O’Donohue, Aimee, Li, Guangmin, Del Rosario, Geoffrey, He, Jintang, Liu, Luna, Ng, Carl, Su, Dian, Lewis Phillips, Gail D, Kozak, Katherine R, Yu, Shang-Fan, Xu, Keyang, Leipold, Douglas, Wai, John
Published in Bioconjugate chemistry (16.08.2017)
Published in Bioconjugate chemistry (16.08.2017)
Get full text
Journal Article
Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates
Sukumaran, Siddharth, Gadkar, Kapil, Zhang, Crystal, Bhakta, Sunil, Liu, Luna, Xu, Keyang, Raab, Helga, Yu, Shang-Fan, Mai, Elaine, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ramanujan, Saroja, Junutula, Jagath R., Lin, Kedan
Published in Pharmaceutical research (01.06.2015)
Published in Pharmaceutical research (01.06.2015)
Get full text
Journal Article
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates
Staben, Leanna R., Koenig, Stefan G., Lehar, SophieM, Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Xin Linghu, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.
Published in Nature chemistry (01.12.2016)
Published in Nature chemistry (01.12.2016)
Get full text
Journal Article
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers
Ohri, Rachana, Bhakta, Sunil, Fourie-O’Donohue, Aimee, dela Cruz-Chuh, Josefa, Tsai, Siao Ping, Cook, Ryan, Wei, Binqing, Ng, Carl, Wong, Athena W, Bos, Aaron B, Farahi, Farzam, Bhakta, Jiten, Pillow, Thomas H, Raab, Helga, Vandlen, Richard, Polakis, Paul, Liu, Yichin, Erickson, Hans, Junutula, Jagath R, Kozak, Katherine R
Published in Bioconjugate chemistry (21.02.2018)
Published in Bioconjugate chemistry (21.02.2018)
Get full text
Journal Article
Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering
Pillow, Thomas H, Tien, Janet, Parsons-Reponte, Kathryn L, Bhakta, Sunil, Li, Hao, Staben, Leanna R, Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D, Su, Dian, Wu, Elmer, Spencer, Susan D, Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R, Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D, Scheller, Richard H, Polakis, Paul, Sliwkowski, Mark X, Flygare, John A, Junutula, Jagath R
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
Get full text
Journal Article
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Chen, Jinhua, Corr, Nicholas, dela Cruz-Chuh, Josefa, Del Rosario, Geoffrey, Fullerton, Aaron, Hartman, Steven J, Jiang, Fan, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liling, Lu, Ying, Mulvihill, Melinda M, Murray, Jeremy M, O’Donohue, Aimee, Rowntree, Rebecca K, Sawyer, William S, Staben, Leanna R, Wai, John, Wang, Jian, Wei, BinQing, Wei, Wentao, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhang, Hongyan, Zhang, Shenhua, Zhao, Yongxin, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
Get full text
Journal Article
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Bhakta, Sunil, Blaquiere, Nicole, Chen, Jinhua, dela Cruz-Chuh, Josefa, Gascoigne, Karen E, Hartman, Steven J, He, Mingtao, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liang, Liu, Liling, Liu, Qi, Lu, Ying, Meng, Fanwei, Mulvihill, Melinda M, O’Donohue, Aimee, Rowntree, Rebecca K, Staben, Leanna R, Staben, Steven T, Wai, John, Wang, Jian, Wei, BinQing, Wilson, Catherine, Xin, Jianfeng, Xu, Zijin, Yao, Hui, Zhang, Donglu, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
Get full text
Journal Article
Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification
Su, Dian, Kozak, Katherine R, Sadowsky, Jack, Yu, Shang-Fan, Fourie-O’Donohue, Aimee, Nelson, Christopher, Vandlen, Richard, Ohri, Rachana, Liu, Luna, Ng, Carl, He, Jintang, Davis, Helen, Lau, Jeff, Del Rosario, Geoffrey, Cosino, Ely, Cruz-Chuh, Josefa dela, Ma, Yong, Zhang, Donglu, Darwish, Martine, Cai, Wenwen, Chen, Chunjiao, Zhou, Hongxiang, Lu, Jiawei, Liu, Yichin, Kaur, Surinder, Xu, Keyang, Pillow, Thomas H
Published in Bioconjugate chemistry (18.04.2018)
Published in Bioconjugate chemistry (18.04.2018)
Get full text
Journal Article
Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates
Vollmar, Breanna S, Wei, Binqing, Ohri, Rachana, Zhou, Jianhui, He, Jintang, Yu, Shang-Fan, Leipold, Douglas, Cosino, Ely, Yee, Sharon, Fourie-O’Donohue, Aimee, Li, Guangmin, Phillips, Gail L, Kozak, Katherine R, Kamath, Amrita, Xu, Keyang, Lee, Genee, Lazar, Greg A, Erickson, Hans K
Published in Bioconjugate chemistry (18.10.2017)
Published in Bioconjugate chemistry (18.10.2017)
Get full text
Journal Article
Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer
Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
Published in Oncotarget (22.10.2019)
Published in Oncotarget (22.10.2019)
Get full text
Journal Article
Improved translation of stability for conjugated antibodies using an in vitro whole blood assay
Fourie-O'Donohue, Aimee, Chu, Phillip Y, Dela Cruz Chuh, Josefa, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C, Sawyer, William S, Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H, Sadowsky, Jack, Dragovich, Peter S, Liu, Yichin, Kozak, Katherine R
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
Get full text
Journal Article
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody–Drug Conjugates
Pei, Zhonghua, Chen, Chunjiao, Chen, Jinhua, Cruz-Chuh, Josefa dela, Delarosa, Reginald, Deng, Yuzhong, Fourie-O’Donohue, Aimee, Figueroa, Isabel, Guo, Jun, Jin, Weiwei, Khojasteh, S. Cyrus, Kozak, Katherine R, Latifi, Brandon, Lee, James, Li, Guangmin, Lin, Eva, Liu, Liling, Lu, Jiawei, Martin, Scott, Ng, Carl, Nguyen, Trung, Ohri, Rachana, Lewis Phillips, Gail, Pillow, Thomas H, Rowntree, Rebecca K, Stagg, Nicola J, Stokoe, David, Ulufatu, Sheila, Verma, Vishal A, Wai, John, Wang, Jing, Xu, Keyang, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S
Published in Molecular pharmaceutics (04.09.2018)
Published in Molecular pharmaceutics (04.09.2018)
Get full text
Journal Article
Total Antibody Quantification for MMAE-Conjugated Antibody–Drug Conjugates: Impact of Assay Format and Reagents
Kozak, Katherine R, Tsai, Siao Ping, Fourie-O’Donohue, Aimee, dela Cruz Chuh, Josefa, Roth, Leslie, Cook, Ryan, Chan, Elton, Chan, Pamela, Darwish, Martine, Ohri, Rachana, Raab, Helga, Zhang, Crystal, Lin, Kedan, Wong, Wai Lee T
Published in Bioconjugate chemistry (15.05.2013)
Published in Bioconjugate chemistry (15.05.2013)
Get full text
Journal Article
Suppression of Myeloid Cell-Derived Proinflammatory Cytokines with Celmod Agents: Implications for CRS with T-Cell Engagers (TCEs)
Jeyaraju, Danny V, Alapa, Maryam, O'Donohue, Aimee, La Motte-Mohs, Ross, Boss, Isaac W., Hagner, Patrick, Pourdehnad, Michael, Burgess, Michael R., Pierceall, William E., Thakurta, Anjan
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
Get full text
Journal Article
Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
Get full text
Journal Article
An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models
Scales, Suzie J, Gupta, Nidhi, Pacheco, Glenn, Firestein, Ron, French, Dorothy M, Koeppen, Hartmut, Rangell, Linda, Barry-Hamilton, Vivian, Luis, Elizabeth, Chuh, Josefa, Zhang, Yin, Ingle, Gladys S, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Ross, Sarajane, Dennis, Mark S, Spencer, Susan D
Published in Molecular cancer therapeutics (01.11.2014)
Published in Molecular cancer therapeutics (01.11.2014)
Get full text
Journal Article