Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase
Bagal, Sharan K, Gregson, Clare, O’ Donovan, Daniel H, Pike, Kurt G, Bloecher, Andrew, Barton, Peter, Borodovsky, Alexandra, Code, Erin, Fillery, Shaun M, Hsu, Jessie Hao-Ru, Kawatkar, Sameer P, Li, Chengzhi, Longmire, David, Nai, Youfeng, Nash, Samuel C, Pike, Andrew, Robinson, James, Read, Jon A, Rawlins, Phillip B, Shen, Minhui, Tang, Jia, Wang, Peng, Woods, Haley, Williamson, Beth
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
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Targeting PRC2 for the treatment of cancer: an updated patent review (2016 - 2020)
Dockerill, Milly, Gregson, Clare, O' Donovan, Daniel H
Published in Expert opinion on therapeutic patents (01.02.2021)
Published in Expert opinion on therapeutic patents (01.02.2021)
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C−H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity
O' Donovan, Daniel H., Aillard, Paul, Berger, Martin, de la Torre, Aurélien, Petkova, Desislava, Knittl‐Frank, Christian, Geerdink, Danny, Kaiser, Marcel, Maulide, Nuno
Published in Angewandte Chemie International Edition (13.08.2018)
Published in Angewandte Chemie International Edition (13.08.2018)
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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
Hsu, Jessie Hao-Ru, Rasmusson, Timothy, Robinson, James, Pachl, Fiona, Read, Jon, Kawatkar, Sameer, O’ Donovan, Daniel H., Bagal, Sharan, Code, Erin, Rawlins, Philip, Argyrou, Argyrides, Tomlinson, Ronald, Gao, Ning, Zhu, Xiahui, Chiarparin, Elisabetta, Jacques, Kelly, Shen, Minhui, Woods, Haley, Bednarski, Emma, Wilson, David M., Drew, Lisa, Castaldi, M. Paola, Fawell, Stephen, Bloecher, Andrew
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Published in Cell chemical biology (16.01.2020)
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Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice
O'Donovan, Daniel H., Baker, David, Ciotta, Giovanni, Degorce, Sebastien L., Demanze, Sylvain, Dockerill, Milly, Escudero-Ibarz, Leire, Ireland, Lucy, Mao, Yumeng, Packer, Martin J., Robinson, James, Scarfe, Graeme, Tang, Haoran, Valge-Archer, Viia
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
Published in Bioorganic & medicinal chemistry letters (15.11.2023)
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Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction
Iegre, Jessica, Brear, Paul, Baker, David J, Tan, Yaw Sing, Atkinson, Eleanor L, Sore, Hannah F, O' Donovan, Daniel H, Verma, Chandra S, Hyvönen, Marko, Spring, David R
Published in Chemical science (Cambridge) (21.05.2019)
Published in Chemical science (Cambridge) (21.05.2019)
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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase
O' Donovan, Daniel H., Gregson, Clare, Packer, Martin J., Greenwood, Ryan, Pike, Kurt G., Kawatkar, Sameer, Bloecher, Andrew, Robinson, James, Read, Jon, Code, Erin, Hsu, Jessie Hao-Ru, Shen, Minhui, Woods, Haley, Barton, Peter, Fillery, Shaun, Williamson, Beth, Rawlins, Philip B., Bagal, Sharan K.
Published in Bioorganic & medicinal chemistry letters (01.05.2021)
Published in Bioorganic & medicinal chemistry letters (01.05.2021)
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Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
Iegre, Jessica, Ahmed, Niaz S., Gaynord, Josephine S., Wu, Yuteng, Herlihy, Kara M., Tan, Yaw Sing, Lopes-Pires, Maria E., Jha, Rupam, Lau, Yu Heng, Sore, Hannah F., Verma, Chandra, O'Donovan, Daniel H., Pugh, Nicholas, Spring, David R.
Published in Chemical science (Cambridge) (28.05.2018)
Published in Chemical science (Cambridge) (28.05.2018)
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Substitution effects on neutral and protonated pyridine derivatives along the periodic table
Blanco, Fernando, O’ Donovan, Daniel H., Alkorta, Ibon, Elguero, José
Published in Structural chemistry (01.04.2008)
Published in Structural chemistry (01.04.2008)
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The reductive cleavage of picolinic amides
O’ Donovan, Daniel H., De Fusco, Claudia, Spring, David R.
Published in Tetrahedron letters (06.07.2016)
Published in Tetrahedron letters (06.07.2016)
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Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00798a
Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Verma, Chandra S., Hyvönen, Marko, Spring, David R.
Published in Chemical science (Cambridge) (12.04.2019)
Published in Chemical science (Cambridge) (12.04.2019)
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Stapled peptides as a new technology to investigate protein-protein interactions in human plateletsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00284c
Iegre, Jessica, Ahmed, Niaz S, Gaynord, Josephine S, Wu, Yuteng, Herlihy, Kara M, Tan, Yaw Sing, Lopes-Pires, Maria E, Jha, Rupam, Lau, Yu Heng, Sore, Hannah F, Verma, Chandra, O' Donovan, Daniel H, Pugh, Nicholas, Spring, David R
Year of Publication 23.05.2018
Year of Publication 23.05.2018
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Journal Article
Stapled peptides as a new technology to investigate protein–protein interactions in human platelets† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00284c
Iegre, Jessica, Ahmed, Niaz S., Gaynord, Josephine S., Wu, Yuteng, Herlihy, Kara M., Tan, Yaw Sing, Lopes-Pires, Maria E., Jha, Rupam, Lau, Yu Heng, Sore, Hannah F., Verma, Chandra, O' Donovan, Daniel H., Pugh, Nicholas, Spring, David R.
Published in Chemical science (Cambridge) (25.04.2018)
Published in Chemical science (Cambridge) (25.04.2018)
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Journal Article
C‐H‐Aktivierung ermöglicht eine kurze Totalsynthese von Chinin und Analoga mit erhöhter Anti‐Malaria‐Aktivität
O' Donovan, Daniel H., Aillard, Paul, Berger, Martin, de la Torre, Aurélien, Petkova, Desislava, Knittl‐Frank, Christian, Geerdink, Danny, Kaiser, Marcel, Maulide, Nuno
Published in Angewandte Chemie (13.08.2018)
Published in Angewandte Chemie (13.08.2018)
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Journal Article
C‐H‐Aktivierung ermöglicht eine kurze Totalsynthese von Chinin und Analoga mit erhöhter Anti‐Malaria‐Aktivität
O' Donovan, Daniel H, Aillard, Paul, Berger, Martin, de la Torre, Aurélien, Petkova, Desislava, Christian Knittl‐Frank, Geerdink, Danny, Kaiser, Marcel, Maulide, Nuno
Published in Angewandte Chemie (01.08.2018)
Published in Angewandte Chemie (01.08.2018)
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