Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G
Published in Nature medicine (01.08.2016)
Published in Nature medicine (01.08.2016)
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Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
Nywening, Timothy M, MD, Wang-Gillam, Andrea, MD, Sanford, Dominic E, MD, Belt, Brian A, MA, Panni, Roheena Z, MD, Cusworth, Brian M, BA, Toriola, Adetunji T, MD, Nieman, Rebecca K, MS, Worley, Lori A, BS, Yano, Motoyo, MD, Fowler, Kathryn J, MD, Lockhart, A Craig, MD, Suresh, Rama, MD, Tan, Benjamin R, MD, Lim, Kian-Huat, MD, Fields, Ryan C, MD, Strasberg, Steven M, Prof, Hawkins, William G, Prof, DeNardo, David G, PhD, Goedegebuure, S Peter, PhD, Linehan, David C, Dr Prof
Published in The lancet oncology (01.05.2016)
Published in The lancet oncology (01.05.2016)
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CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
Zhu, Yu, Knolhoff, Brett L, Meyer, Melissa A, Nywening, Timothy M, West, Brian L, Luo, Jingqin, Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C, DeNardo, David G
Published in Cancer research (Chicago, Ill.) (15.09.2014)
Published in Cancer research (Chicago, Ill.) (15.09.2014)
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Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C
Published in Gut (01.06.2018)
Published in Gut (01.06.2018)
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Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer
Rashid, Naim U, Peng, Xianlu L, Jin, Chong, Moffitt, Richard A, Volmar, Keith E, Belt, Brian A, Panni, Roheena Z, Nywening, Timothy M, Herrera, Silvia G, Moore, Kristin J, Hennessey, Sarah G, Morrison, Ashley B, Kawalerski, Ryan, Nayyar, Apoorve, Chang, Audrey E, Schmidt, Benjamin, Kim, Hong Jin, Linehan, David C, Yeh, Jen Jen
Published in Clinical cancer research (01.01.2020)
Published in Clinical cancer research (01.01.2020)
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Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
Meyer, Melissa A., Baer, John M., Knolhoff, Brett L., Nywening, Timothy M., Panni, Roheena Z., Su, Xinming, Weilbaecher, Katherine N., Hawkins, William G., Ma, Cynthia, Fields, Ryan C., Linehan, David C., Challen, Grant A., Faccio, Roberta, Aft, Rebecca L., DeNardo, David G.
Published in Nature communications (28.03.2018)
Published in Nature communications (28.03.2018)
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Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer
Grossman, Julie G, Nywening, Timothy M, Belt, Brian A, Panni, Roheena Z, Krasnick, Bradley A, DeNardo, David G, Hawkins, William G, Goedegebuure, S Peter, Linehan, David C, Fields, Ryan C
Published in Oncoimmunology (02.09.2018)
Published in Oncoimmunology (02.09.2018)
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GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity
Ruffolo, Luis I, Jackson, Katherine M, Kuhlers, Peyton C, Dale, Benjamin S, Figueroa Guilliani, Nathania M, Ullman, Nicholas A, Burchard, Paul R, Qin, Shuyang S, Juviler, Peter G, Keilson, Jessica Millian, Morrison, Ashley B, Georger, Mary, Jewell, Rachel, Calvi, Laura M, Nywening, Timothy M, O'Dell, Michael R, Hezel, Aram F, De Las Casas, Luis, Lesinski, Gregory B, Yeh, Jen Jen, Hernandez-Alejandro, Roberto, Belt, Brian A, Linehan, David C
Published in Gut (01.07.2022)
Published in Gut (01.07.2022)
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Plasma Ceramide C24:0/C16:0 Ratio is Associated with Improved Survival in Patients with Pancreatic Ductal Adenocarcinoma
Mitchell, Joshua D., Panni, Usman, Fergestrom, Nicole, Toriola, Adetunji T., Nywening, Timothy M., Goedegebuure, S. Peter, Jiang, Xuntian, Mudd, Jacqueline L., Cao, Yin, Ippolito, Joseph, Fields, Ryan C., Hawkins, William G., Peterson, Linda R.
Published in Annals of surgical oncology (01.12.2024)
Published in Annals of surgical oncology (01.12.2024)
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ASO Visual Abstract: Plasma Ceramide C24:0/C16:0 Ratio is Associated with Improved Survival in Patients with Pancreatic Ductal Adenocarcinoma
Mitchell, Joshua D, Panni, Usman, Fergestrom, Nicole, Toriola, Adetunji T, Nywening, Timothy M, Goedegebuure, S Peter, Jiang, Xuntian, Mudd, Jacqueline L, Cao, Yin, Ippolito, Joseph, Fields, Ryan C, Hawkins, William G, Peterson, Linda R
Published in Annals of surgical oncology (25.10.2024)
Published in Annals of surgical oncology (25.10.2024)
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Operative Site Drainage after Hepatectomy: A Propensity Score Matched Analysis Using the American College of Surgeons NSQIP Targeted Hepatectomy Database
Brauer, David G., MD, MPHS, Nywening, Timothy M., MD, MS, MPHS, Jaques, David P., MD, FACS, Doyle, M.B. Majella, MD, MBA, FACS, Chapman, William C., MD, FACS, Fields, Ryan C., MD, FACS, Hawkins, William G., MD, FACS
Published in Journal of the American College of Surgeons (01.12.2016)
Published in Journal of the American College of Surgeons (01.12.2016)
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Whipple-specific complications result in prolonged length of stay not accounted for in ACS-NSQIP Surgical Risk Calculator
Cusworth, Brian M, Krasnick, Bradley A, Nywening, Timothy M, Woolsey, Cheryl A, Fields, Ryan C, Doyle, Maria M, Liu, Jingxia, Hawkins, William G
Published in HPB (Oxford, England) (01.02.2017)
Published in HPB (Oxford, England) (01.02.2017)
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Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic
Ohman, Kerri A, Hashim, Yassar M, Vangveravong, Suwanna, Nywening, Timothy M, Cullinan, Darren R, Goedegebuure, S Peter, Liu, Jingxia, Van Tine, Brian A, Tiriac, Herve, Tuveson, David A, DeNardo, David G, Spitzer, Dirk, Mach, Robert H, Hawkins, William G
Published in Oncotarget (07.06.2016)
Published in Oncotarget (07.06.2016)
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Abstract 4150: Blockade of CXCR2 mediated granulocytic MDSC recruitment synergizes with CCR2 inhibition of inflammatory monocytes and restores anti-tumor immunity in pancreatic adenocarcinoma
Nywening, Timothy M., Belt, Brian A., Panni, Roheena Z., Cullinan, Darren, Sanford, Dominic E., Fields, Ryan C., Hawkins, William G., DeNardo, David G., Gillanders, William E., Goedegebuure, Peter, Linehan, David C.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Heated intraperitoneal chemotherapy is associated with improved overall survival among advanced-stage ovarian cancer patients undergoing interval cytoreductive surgery: A National Cancer Database analysis
Kohut, Adrian, Anderson, Matthew, Yasukawa, Maya, Handley, Katelyn, Nywening, Timothy, Karachristos, Andreas, English, Diana, Rutherford, Thomas
Published in Gynecologic oncology (01.11.2024)
Published in Gynecologic oncology (01.11.2024)
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Evolving role of cytoreduction and HIPEC for colorectal cancer
Loftus, Alexander, Hoehn, Richard, Nywening, Timothy
Published in Seminars in colon and rectal surgery (01.09.2023)
Published in Seminars in colon and rectal surgery (01.09.2023)
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Abstract B58: Combination therapy with the novel small molecule drug conjugate SW V-49 and gemcitabine is a potent pancreatic cancer therapeutic
Ohman, Kerri A., Nywening, Timothy M., Vangveravong, Suwanna, Spitzer, Dirk, Hawkins, William G.
Published in Cancer research (Chicago, Ill.) (15.12.2016)
Published in Cancer research (Chicago, Ill.) (15.12.2016)
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Abstract 5640: Development of a personalized pancreatic cancer vaccine
Cullinan, Darren R., McLellan, Michael, Zhang, Xiuli, Nywening, Timothy M., Miller, Chris A., Goedegebuure, S. Peter, Hawkins, William G., Gillanders, William E.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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