ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells
Chen, Wei, Nyuydzefe, Melanie S., Weiss, Jonathan M., Zhang, Jingya, Waksal, Samuel D., Zanin-Zhorov, Alexandra
Published in Scientific reports (09.11.2018)
Published in Scientific reports (09.11.2018)
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Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Nyuydzefe, Melanie S., Chen, Wei, Scher, Jose U., Mo, Rigen, Depoil, David, Rao, Nishta, Liu, Ben, Wei, Jianlu, Lucas, Sarah, Koslow, Matthew, Roche, Maria, Schueller, Olivier, Weiss, Sara, Poyurovsky, Masha V., Tonra, James, Hippen, Keli L, Dustin, Michael L., Blazar, Bruce R., Liu, Chuan-ju, Waksal, Samuel D., Dinarello, Charles A.
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
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Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
Flynn, Ryan, Paz, Katelyn, Du, Jing, Reichenbach, Dawn K., Taylor, Patricia A., Panoskaltsis-Mortari, Angela, Vulic, Ante, Luznik, Leo, MacDonald, Kelli K.P., Hill, Geoffrey R., Nyuydzefe, Melanie S., Weiss, Jonathan M., Chen, Wei, Trzeciak, Alissa, Serody, Jon S., Aguilar, Ethan G., Murphy, William J., Maillard, Ivan, Munn, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, Waksal, Samuel D., Zanin-Zhorov, Alexandra, Blazar, Bruce R.
Published in Blood (28.04.2016)
Published in Blood (28.04.2016)
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Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
Zanin-Zhorov, Alexandra, Weiss, Jonathan M, Trzeciak, Alissa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie S, Arencibia, Carmen, Polimera, Seetharam, Schueller, Olivier, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen M, Kunjravia, Norma, Cueto, Inna, Soung, Jennifer, Fleischmann, Roy M, Kivitz, Alan, Lebwohl, Mark, Nunez, Margarita, Woodson, Johnnie, Smith, Shondra L, West, Robert F, Berger, Mark, Krueger, James G, Ryan, John L, Waksal, Samuel D
Published in The Journal of immunology (1950) (15.05.2017)
Published in The Journal of immunology (1950) (15.05.2017)
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ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings
Weiss, Jonathan M, Chen, Wei, Nyuydzefe, Melanie S, Trzeciak, Alissa, Flynn, Ryan, Tonra, James R, Marusic, Suzana, Blazar, Bruce R, Waksal, Samuel D, Zanin-Zhorov, Alexandra
Published in Science signaling (19.07.2016)
Published in Science signaling (19.07.2016)
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The selective ROCK2 inhibitor KD025 reduces IL‐17 secretion in human peripheral blood mononuclear cells independent of IL‐1 and IL‐6
Tengesdal, Isak W., Kitzenberg, David, Li, Suzhao, Nyuydzefe, Melanie S., Chen, Wei, Weiss, Jonathan M., Zhang, Jingya, Waksal, Samuel D., Zanin‐Zhorov, Alexandra, Dinarello, Charles A.
Published in European journal of immunology (01.10.2018)
Published in European journal of immunology (01.10.2018)
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Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism
Zanin-Zhorov, Alexandra, Chen, Wei, Moretti, Julien, Nyuydzefe, Melanie S., Zhorov, Iris, Munshi, Rashmi, Ghosh, Malavika, Serdjebi, Cindy, MacDonald, Kelli, Blazar, Bruce R., Palmer, Melissa, Waksal, Samuel D.
Published in Communications biology (18.11.2023)
Published in Communications biology (18.11.2023)
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Selectivity matters: novel ROCK2 inhibitor down-regulates established liver fibrosis via concurrent targeting of inflammatory, fibrotic and metabolic pathways
Zanin-Zhorov, Alexandra, Chen, Wei, Nyuydzefe, Melanie, Moretti, Julien, Zhorov, Iris, Munshi, Rashmi, Ghosh, Malavika, MacDonald, Kelli, Blazar, Bruce, Waksal, Sam
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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ROCK2 regulates microglia proliferation and neuronal survival after traumatic brain injury
Willis, Emily F., Kim, Seung Jae, Chen, Wei, Nyuydzefe, Melanie, MacDonald, Kelli P.A., Zanin-Zhorov, Alexandra, Ruitenberg, Marc J., Vukovic, Jana
Published in Brain, behavior, and immunity (01.03.2024)
Published in Brain, behavior, and immunity (01.03.2024)
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ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis
Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele W.L., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra, MacDonald, Kelli P.A.
Published in JHEP reports (01.01.2022)
Published in JHEP reports (01.01.2022)
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ROCK2 signaling is required for development and function of T follicular helper cells (HUM3P.247)
Weiss, Jonathan, Chen, Wei, Nyuydzefe, melanie, Flynn, Ryan, Tonra, James, Marusic, Suzana, Blazar, Bruce, Waksal, Samuel, Zanin-Zhorov, Alexandra
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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Journal Article
Selective oral ROCK2 inhibitor reduces clinical scores in patients with Psoriasis Vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10 levels
Zanin-Zhorov, Alexandra, Weiss, Jonathan M, Trzeciak, Alyssa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie, Arencibia, Carmen, Polimera, Seetharam, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen, Kunjravia, Norma, Cueto, Inna, Berger, Mark, Krueger, James, Ryan, John L, Waksal, Samuel D
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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Journal Article
Selective ROCK2 inhibitor down-regulates pro-inflammatory T cell responses via shifting Th17/Treg balance (IRM6P.711)
Zanin-Zhorov, Alexandra, Mo, Rigen, Scher, Jose, Nyuydzefe, Melanie, Weiss, Jonathan, Schueller, Olivier, Weiss, Sara, Poyurovsky, Masha, Dustin, Michael, Abramson, Steven, Waksal, Samuel
Published in The Journal of immunology (1950) (01.05.2014)
Published in The Journal of immunology (1950) (01.05.2014)
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Selective ROCK2 inhibitor reverses experimental chronic graft-versus-host disease via concurrent regulation of STAT3/STAT5 phosphorylation (TRAN1P.933)
Zanin-Zhorov, Alexandra, Flynn, Ryan, Luznik, Leo, Nyuydzefe, melanie, Panoskaltsis-Mortari, Angela, Du, Jing, Goodman, Katelyn, Weiss, Jonathan, Chen, Wei, Serody, Jonathan, MacDonald, Kelli, Hill, Geoffrey, O'Shea, John, Waksal, Samuel, Blazar, Bruce
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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Journal Article
A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD)
Zanin-Zhorov, Alexandra, Flynn, Ryan, Luznik, Leo, Panoskaltsis-Mortari, Angela, Jing, Du, Goodman, Katelyn, Weiss, Jonathan, Nyuydzefe, Melanie, Chen, Wei, Serody, Jonathan S, MacDonald, Kelli PA, Hill, Geoffrey R, O’Shea, John, Roche, Maria, Weiss, Sara, Waksal, Samuel, Blazar, Bruce R.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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