Search Results - "Nyalapatla, Prasanth R." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Design and Synthesis of Highly Potent HIV‑1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure–Activity Studies, Biological and X‑ray Structural Analysis

Design and Synthesis of Highly Potent HIV‑1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure–Activity Studies, Biological and X‑ray Structural Analysis

by Ghosh, Arun K, R. Nyalapatla, Prasanth, Kovela, Satish, Rao, Kalapala Venkateswara, Brindisi, Margherita, Osswald, Heather L, Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (24.05.2018)

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Enantioselective Total Synthesis of (+)-Amphirionin‑4

Enantioselective Total Synthesis of (+)-Amphirionin‑4

by Ghosh, Arun K, Nyalapatla, Prasanth R
Published in Organic letters (06.05.2016)

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Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans

Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans

by Ghosh, Arun K., Nyalapatla, Prasanth R.
Published in Tetrahedron (06.04.2017)

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Fluorescent Probes for Monitoring Serine Ubiquitination

Fluorescent Probes for Monitoring Serine Ubiquitination

by Puvar, Kedar, Saleh, Aya M, Curtis, Ryan W, Zhou, Yiyang, R. Nyalapatla, Prasanth, Fu, Jiaqi, Rovira, Alexander R, Tor, Yitzhak, Luo, Zhao-Qing, Ghosh, Arun K, Wirth, Mary J, Chmielewski, Jean, Kinzer-Ursem, Tamara L, Das, Chittaranjan
Published in Biochemistry (Easton) (07.04.2020)

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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

by Bulut, Haydar, Hattori, Shin-Ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Scientific reports (30.06.2020)

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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

by Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Published in eLife (17.10.2017)

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Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

by Ghosh, Arun K., Brindisi, Margherita, Nyalapatla, Prasanth R., Takayama, Jun, Ella-Menye, Jean-Rene, Yashchuk, Sofiya, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry (01.10.2017)

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Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands

Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands

by Ghosh, Arun K., Martyr, Cuthbert D., Kassekert, Luke A., Nyalapatla, Prasanth R., Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., Amano, Masayuki, Mitsuya, Hiroaki
Published in Organic & biomolecular chemistry (14.10.2015)

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Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS

by Tomar, Sakshi, Johnston, Melanie L, St John, Sarah E, Osswald, Heather L, Nyalapatla, Prasanth R, Paul, Lake N, Ghosh, Arun K, Denison, Mark R, Mesecar, Andrew D
Published in The Journal of biological chemistry (07.08.2015)

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Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

by Ghosh, Arun K, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Osswald, Heather L, Martyr, Cuthbert D, Aoki, Manabu, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Bulut, Haydar, Das, Debananda, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (25.05.2017)

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Co(II)‐salen catalyzed stereoselective cyclopropanation of fluorinated styrenes

Co(II)‐salen catalyzed stereoselective cyclopropanation of fluorinated styrenes

by Tai, Serene, Maskrey, Taber S., Nyalapatla, Prasanth R., Wipf, Peter
Published in Chirality (New York, N.Y.) (01.12.2019)

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Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

by Hattori, Shin-Ichiro, Hayashi, Hironori, Bulut, Haydar, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Hasegawa, Kazuya, Aoki, Manabu, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Antimicrobial agents and chemotherapy (01.06.2019)

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Correction to Enantioselective Total Synthesis of (+)-Amphirionin‑4

Correction to Enantioselective Total Synthesis of (+)-Amphirionin‑4

by Ghosh, Arun K, Nyalapatla, Prasanth R
Published in Organic letters (15.07.2016)

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Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants

Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants

by Ghosh, Arun K., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Kovela, Satish, Brindisi, Margherita, Osswald, Heather L., Sekhara Reddy, Bhavanam, Agniswamy, Johnson, Wang, Yuan‐Fang, Aoki, Manabu, Hattori, Shin‐ichiro, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (23.04.2018)

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Highly Potent HIV‑1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X‑ray Studies

Highly Potent HIV‑1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X‑ray Studies

by Ghosh, Arun K, Parham, Garth L, Martyr, Cuthbert D, Nyalapatla, Prasanth R, Osswald, Heather L, Agniswamy, Johnson, Wang, Yuan-Fang, Amano, Masayuki, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (12.09.2013)

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X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

by St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., Mesecar, Andrew D.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)

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A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro

A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro

by Amano, Masayuki, Tojo, Yasushi, Salcedo-Gómez, Pedro Miguel, Parham, Garth L, Nyalapatla, Prasanth R, Das, Debananda, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Antimicrobial agents and chemotherapy (01.05.2015)

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Zinc Catalyzed and Mediated Asymmetric Propargylation of Trifluoromethyl Ketones with a Propargyl Boronate

Zinc Catalyzed and Mediated Asymmetric Propargylation of Trifluoromethyl Ketones with a Propargyl Boronate

by Fandrick, Daniel R, Reeves, Jonathan T, Bakonyi, Johanna M, Nyalapatla, Prasanth R, Tan, Zhulin, Niemeier, Oliver, Akalay, Deniz, Fandrick, Keith R, Wohlleben, Wolfgang, Ollenberger, Swetlana, Song, Jinhua J, Sun, Xiufeng, Qu, Bo, Haddad, Nizar, Sanyal, Sanjit, Shen, Sherry, Ma, Shengli, Byrne, Denis, Chitroda, Ashish, Fuchs, Victor, Narayanan, Bikshandarkoil A, Grinberg, Nelu, Lee, Heewon, Yee, Nathan, Brenner, Michael, Senanayake, Chris H
Published in Journal of organic chemistry (19.04.2013)

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A New Synthesis of Gefitinib

A New Synthesis of Gefitinib

by Maskrey, Taber S., Kristufek, Tyler, LaPorte, Matthew G., Nyalapatla, Prasanth R., Wipf, Peter
Published in Synlett (01.03.2019)

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X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

by St. John, Sarah E., Therkelsen, Matthew D., Nyalapatla, Prasanth R., Osswald, Heather L., Ghosh, Arun K., Mesecar, Andrew D.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)

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