The tethered peptide activation mechanism of adhesion GPCRs
Barros-Álvarez, Ximena, Nwokonko, Robert M., Vizurraga, Alexander, Matzov, Donna, He, Feng, Papasergi-Scott, Makaía M., Robertson, Michael J., Panova, Ouliana, Yardeni, Eliane Hadas, Seven, Alpay B., Kwarcinski, Frank E., Su, Hongyu, Peroto, Maria Claudia, Meyerowitz, Justin G., Shalev-Benami, Moran, Tall, Gregory G., Skiniotis, Georgios
Published in Nature (London) (28.04.2022)
Published in Nature (London) (28.04.2022)
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A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Zhang, Xuexin, Pathak, Trayambak, Yoast, Ryan, Emrich, Scott, Xin, Ping, Nwokonko, Robert M., Johnson, Martin, Wu, Shilan, Delierneux, Céline, Gueguinou, Maxime, Hempel, Nadine, Putney, James W., Gill, Donald L., Trebak, Mohamed
Published in Nature communications (29.04.2019)
Published in Nature communications (29.04.2019)
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An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1
Zhou, Yandong, Jennette, Michelle R., Ma, Guolin, Kazzaz, Sarah A., Baraniak, James H., Nwokonko, Robert M., Groff, Mallary L., Velasquez-Reynel, Marcela, Huang, Yun, Wang, Youjun, Gill, Donald L.
Published in Nature communications (30.10.2023)
Published in Nature communications (30.10.2023)
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The STIM1-binding site nexus remotely controls Orai1 channel gating
Zhou, Yandong, Cai, Xiangyu, Loktionova, Natalia A., Wang, Xianming, Nwokonko, Robert M., Wang, Xizhuo, Wang, Youjun, Rothberg, Brad S., Trebak, Mohamed, Gill, Donald L.
Published in Nature communications (08.12.2016)
Published in Nature communications (08.12.2016)
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STIM1 dimers undergo unimolecular coupling to activate Orai1 channels
Zhou, Yandong, Wang, Xizhuo, Wang, Xianming, Loktionova, Natalia A., Cai, Xiangyu, Nwokonko, Robert M., Vrana, Erin, Wang, Youjun, Rothberg, Brad S., Gill, Donald L.
Published in Nature communications (24.09.2015)
Published in Nature communications (24.09.2015)
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The remote allosteric control of Orai channel gating
Zhou, Yandong, Nwokonko, Robert M, Baraniak, Jr, James H, Trebak, Mohamed, Lee, Kenneth P K, Gill, Donald L
Published in PLoS biology (30.08.2019)
Published in PLoS biology (30.08.2019)
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Orai channel C-terminal peptides are key modulators of STIM-Orai coupling and calcium signal generation
Baraniak, James H., Zhou, Yandong, Nwokonko, Robert M., Jennette, Michelle R., Kazzaz, Sarah A., Stenson, Jazmin M., Whitsell, Abigale L., Wang, Youjun, Trebak, Mohamed, Gill, Donald L.
Published in Cell reports (Cambridge) (29.06.2021)
Published in Cell reports (Cambridge) (29.06.2021)
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G-protein activation by a metabotropic glutamate receptor
Seven, Alpay B., Barros-Álvarez, Ximena, de Lapeyrière, Marine, Papasergi-Scott, Makaía M., Robertson, Michael J., Zhang, Chensong, Nwokonko, Robert M., Gao, Yang, Meyerowitz, Justin G., Rocher, Jean-Philippe, Schelshorn, Dominik, Kobilka, Brian K., Mathiesen, Jesper M., Skiniotis, Georgios
Published in Nature (London) (15.07.2021)
Published in Nature (London) (15.07.2021)
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The oxytocin signaling complex reveals a molecular switch for cation dependence
Meyerowitz, Justin G., Robertson, Michael J., Barros-Álvarez, Ximena, Panova, Ouliana, Nwokonko, Robert M., Gao, Yang, Skiniotis, Georgios
Published in Nature structural & molecular biology (01.03.2022)
Published in Nature structural & molecular biology (01.03.2022)
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The Orai1 Store-operated Calcium Channel Functions as a Hexamer
Cai, Xiangyu, Zhou, Yandong, Nwokonko, Robert M., Loktionova, Natalia A., Wang, Xianming, Xin, Ping, Trebak, Mohamed, Wang, Youjun, Gill, Donald L.
Published in The Journal of biological chemistry (09.12.2016)
Published in The Journal of biological chemistry (09.12.2016)
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The STIM-Orai coupling interface and gating of the Orai1 channel
Zhou, Yandong, Cai, Xiangyu, Nwokonko, Robert M, Loktionova, Natalia A, Wang, Youjun, Gill, Donald L
Published in Cell calcium (Edinburgh) (01.05.2017)
Published in Cell calcium (Edinburgh) (01.05.2017)
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L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins
Johnson, Martin T., Gudlur, Aparna, Zhang, Xuexin, Xin, Ping, Emrich, Scott M., Yoast, Ryan E., Courjaret, Raphael, Nwokonko, Robert M., Li, Wei, Hempel, Nadine, Machaca, Khaled, Gill, Donald L., Hogan, Patrick G.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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Cross-linking of Orai1 channels by STIM proteins
Zhou, Yandong, Nwokonko, Robert M., Cai, Xiangyu, Loktionova, Natalia A., Abdulqadir, Raz, Xin, Ping, Niemeyer, Barbara A., Wang, Youjun, Trebak, Mohamed, محمد طريبق, Gill, Donald L.
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2018)
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Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor
Cai, Xiangyu, Nwokonko, Robert M., Loktionova, Natalia A., Abdulqadir, Raz, Baraniak, James H., Wang, Youjun, Trebak, Mohamed, Zhou, Yandong, Gill, Donald L.
Published in The Journal of biological chemistry (17.08.2018)
Published in The Journal of biological chemistry (17.08.2018)
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Journal Article
L-type Ca 2+ channel blockers promote vascular remodeling through activation of STIM proteins
Johnson, Martin T, Gudlur, Aparna, Zhang, Xuexin, Xin, Ping, Emrich, Scott M, Yoast, Ryan E, Courjaret, Raphael, Nwokonko, Robert M, Li, Wei, Hempel, Nadine, Machaca, Khaled, Gill, Donald L, Hogan, Patrick G, Trebak, Mohamed
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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Journal Article
The intricate coupling between STIM proteins and Orai channels
Baraniak, James H, Zhou, Yandong, Nwokonko, Robert M, Gill, Donald L
Published in Current opinion in physiology (01.10.2020)
Published in Current opinion in physiology (01.10.2020)
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A key amino acid in STIM1 mediates coupling to gate the Orai1 channel
Zhou, Yandong, Nwokonko, Robert M., Ma, Guolin, Baraniak, James H., Wang, Jian, Jennette, Michelle R., Dokholyan, Nikolay V., Huang, Yun, Gill, Donald L.
Published in Biophysical journal (11.02.2022)
Published in Biophysical journal (11.02.2022)
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Ion Conductance of Orai1 Channel Selectivity-Filter Heterodimers
Cai, Xiangyu, Zhou, Yandong, Nwokonko, Robert M., Loktionova, Natalia A., Gill, Donald L.
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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