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Single and multiple ascending dose studies in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme
Lowe, Stephen L, Goldsmith, Paul, Phipps, Krista M, Kevin, Donnelly B, Biglan, Kevin, Mancini, Michele, Nuthall, Hugh Norman, Mergott, Dustin J., Kielbasa, William
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme, following administration of single and multiple doses to healthy volunteers
Kielbasa, William, Shcherbinin, Sergey, Goldsmith, Paul, Phipps, Krista M, Biglan, Kevin, Mancini, Michele, Russell, David, Constantinescu, Cristian, Gunn, Roger N, Nuthall, Hugh Norman, Mergott, Dustin J., Lowe, Stephen L, Collins, Emily C
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme: Human/Human trials: Anti‐tau
Kielbasa, William, Phipps, Krista M, Tseng, James, Natanegara, Fanni, Cheng, Eden, Monk, Scott A., Bundgaard, Christoffer, Kevin, Donnelly B., Nuthall, Hugh Norman, McDonald, Nicholas, Lindsay‐Scott, Peter, Dreyfus, Nicolas, Hawk, Mai Khanh, Warner, Susan, Biglan, Kevin, Gilmore, Julie A., Zhang, Xiaoyu, Mergott, Dustin J., Lowe, Stephen L.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human: Neuroimaging / evaluating treatments
Shcherbinin, Sergey, Kielbasa, William, Dubois, Susan, Lowe, Stephen L, Phipps, Krista M, Tseng, James, Kevin, Donnelly B, Natanegara, Fanni, Warner, Susan, Dreyfus, Nicolas, Lindsay‐Scott, Peter, Hawk, Mai Khanh, McDonald, Nicholas, Zhang, Xiaoyu, Gilmore, Julie A, Biglan, Kevin, Mergott, Dustin J, Russell, David, Gunn, Roger N, Constantinescu, Cristian, Nuthall, Hugh Norman, Collins, Emily C
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Brain target occupancy of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme: Translation from rat to human
Shcherbinin, Sergey, Kielbasa, William, Dubois, Susan, Lowe, Stephen L, Phipps, Krista M, Tseng, James, Kevin, Donnelly B, Natanegara, Fanni, Warner, Susan, Dreyfus, Nicolas, Lindsay‐Scott, Peter, Hawk, Mai Khanh, McDonald, Nicholas, Zhang, Xiaoyu, Gilmore, Julie A, Biglan, Kevin, Mergott, Dustin J, Russell, David, Gunn, Roger N, Constantinescu, Cristian, Nuthall, Hugh Norman, Collins, Emily C
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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A single ascending dose study in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of O‐GlcNAcase (OGA) enzyme
Kielbasa, William, Phipps, Krista M, Tseng, James, Natanegara, Fanni, Cheng, Eden, Monk, Scott A., Bundgaard, Christoffer, Kevin, Donnelly B., Nuthall, Hugh Norman, McDonald, Nicholas, Lindsay‐Scott, Peter, Dreyfus, Nicolas, Hawk, Mai Khanh, Warner, Susan, Biglan, Kevin, Gilmore, Julie A., Zhang, Xiaoyu, Mergott, Dustin J., Lowe, Stephen L.
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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NOVEL NLRP3 INFLAMMASOME INHIBITORS: EVALUATION IN IL-1β RELEASE AND HIGH-CONTENT ASC-SPECK CELLULAR ASSAYS
Faust, Dorte, Fox, Simon G., Brough, David, Redondo-Castro, Elena, Freeman, Sally, Baldwin, Alex, Reynolds, David, Atkinson, Peter, Nuthall, Hugh Norman, Karran, Eric, Dawson, Lee, Brownlees, Janet, Merritt, Andrew
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
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IL-34:CSF1R SIGNALLING: IN VITRO TARGET VALIDATION FOR MODULATION OF MICROGLIAL PROLIFERATION AND SCREENING FOR POTENTIAL INHIBITORS
Fox, Simon G., Hale, Lisa, Gomez-Nicola, Diego, McCoull, David, Mpamhanga, Chido, Coombs, Peter, Reynolds, David, Atkinson, Peter, Nuthall, Hugh Norman, Karran, Eric, Brownlees, Janet, Taylor, Debra
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
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AN ACADEMIC-PRIVATE PARTNERSHIP FOR THE VALIDATION OF NEW MODELS TO UNDERSTAND TAU-RELATED HYPEREXCITABILITY AND AGGREGATION USING HUMAN-INDUCED PLURIPOTENT STEM CELLS
Garcia Leon, Juan Antonio, Pestana, Francisco, Kreir, Mohamed, Shih, Pei-Yu, Eggermont, Kristel, Terryn, Joke, Stumman, Tina Charlotte, Geraerts, Martine, Craig, Peter James, Nuthall, Hugh norman, Verheyen, An, Royaux, Ines, Fazal, Raheem, Quiles, Ana, Ordovas, Laura, Bruce, Kevin, Foerch, Patrik, Pita Almenar, Juan Diego, Ebneth, Andreas, Verfaillie, Catherine, Socorro, Alfredo Cabrera
Published in Alzheimer's & dementia (01.07.2017)
Published in Alzheimer's & dementia (01.07.2017)
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