Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug‐Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects
Asaumi, Ryuta, Toshimoto, Kota, Tobe, Yoshifusa, Hashizume, Kenta, Nunoya, Ken‐ichi, Imawaka, Haruo, Lee, Wooin, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.03.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2018)
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Robust physiologically based pharmacokinetic model of rifampicin for predicting drug–drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney
Asaumi, Ryuta, Nunoya, Ken‐ichi, Yamaura, Yoshiyuki, Taskar, Kunal S., Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.07.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2022)
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A Human Immortalized Cell-Based Blood–Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug−Brain Permeability Studies
Ito, Ryo, Umehara, Kenta, Suzuki, Shota, Kitamura, Keita, Nunoya, Ken-ichi, Yamaura, Yoshiyuki, Imawaka, Haruo, Izumi, Saki, Wakayama, Naomi, Komori, Takafumi, Anzai, Naohiko, Akita, Hidetaka, Furihata, Tomomi
Published in Molecular pharmaceutics (04.11.2019)
Published in Molecular pharmaceutics (04.11.2019)
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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction
Asaumi, Ryuta, Menzel, Karsten, Lee, Wooin, Nunoya, Ken‐ichi, Imawaka, Haruo, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Published in CPT: pharmacometrics and systems pharmacology (01.11.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.11.2019)
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Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein
Kono, Kenta, Fujimura, Rui, Nakamura, Yuka, Matsuura, Kanoko, Nunoya, Ken-ichi, Yamaura, Yoshiyuki, Imawaka, Haruo, Watanabe, Hiroshi, Maruyama, Toru
Published in Molecular pharmaceutics (07.03.2022)
Published in Molecular pharmaceutics (07.03.2022)
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Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism
Fukuchi, Yukina, Toshimoto, Kota, Mori, Takanori, Kakimoto, Keisuke, Tobe, Yoshifusa, Sawada, Takeshi, Asaumi, Ryuta, Iwata, Takeyuki, Hashimoto, Yoshitaka, Nunoya, Ken-ichi, Imawaka, Haruo, Miyauchi, Seiji, Sugiyam, Yuichi
Published in Journal of pharmaceutical sciences (01.09.2017)
Published in Journal of pharmaceutical sciences (01.09.2017)
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Unique Hydrolysis of an Ester-Type Prodrug of Levodopa in Human Plasma: Relay-Type Role Sharing between Alpha‑1 Acid Glycoprotein and Human Serum Albumin
Kono, Kenta, Fukuchi, Yukina, Okawa, Hoshimi, Nunoya, Ken-ichi, Imawaka, Haruo, Watanabe, Hiroshi, Maruyama, Toru
Published in Molecular pharmaceutics (07.10.2019)
Published in Molecular pharmaceutics (07.10.2019)
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Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha‑1 Acid Glycoprotein
Kono, Kenta, Nunoya, Ken-ichi, Nakamura, Yuka, Bi, Jing, Mukunoki, Ayumi, Takeo, Toru, Nakagata, Naomi, Hitoshi, Maeda, Yamaura, Yoshiyuki, Imawaka, Haruo, Watanabe, Hiroshi, Maruyama, Toru
Published in Molecular pharmaceutics (03.05.2021)
Published in Molecular pharmaceutics (03.05.2021)
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In Vitro Metabolism and Inhibitory Effects of Pranlukast in Human Liver Microsomes
Yoneda, Kazuhiro, Matsumoto, Ichiro, Sutoh, Fumitaka, Higashi, Ryunosuke, Nunoya, Ken-ichi, Nakade, Susumu, Miyata, Yasuyuki, Ogawa, Mikio
Published in Biological & Pharmaceutical Bulletin (01.04.2009)
Published in Biological & Pharmaceutical Bulletin (01.04.2009)
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Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes
Matsunaga, Norikazu, Kaneko, Naomi, Staub, Angelina Yukiko, Nakanishi, Takeo, Nunoya, Ken-ichi, Imawaka, Haruo, Tamai, Ikumi
Published in Drug metabolism and disposition (01.01.2016)
Published in Drug metabolism and disposition (01.01.2016)
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Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions
Muredda, Mario, Nunoya, Ken-Ichi, Burtch-Wright, Ruth A, Kurz, Ebba U, Cole, Susan P C, Deeley, Roger G
Published in Molecular pharmacology (01.11.2003)
Published in Molecular pharmacology (01.11.2003)
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Homologous Unequal Cross-Over within the Human CYP2A Gene Cluster as a Mechanism for the Deletion of the Entire CYP2A6 Gene Associated with the Poor Metabolizer Phenotype
Nunoya, Ken-ichi, Yokoi, Tsuyoshi, Takahashi, Yuki, Kimura, Ranzo, Kinoshita, Moritoshi, Kamataki, Tetsuya
Published in Journal of biochemistry (Tokyo) (01.08.1999)
Published in Journal of biochemistry (Tokyo) (01.08.1999)
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A New CYP2A6 Gene Deletion Responsible for the In Vivo Polymorphic Metabolism of (+)-cis-3,5-Dimethyl-2-(3-pyridyl)thiazolidin-4-one Hydrochloride in Humans
Nunoya, K I, Yokoi, T, Kimura, K, Kainuma, T, Satoh, K, Kinoshita, M, Kamataki, T
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Erratum: In Vitro Metabolism and Inhibitory Effects of Pranlukast in Human Liver Microsomes [Biol. Pharm. Bull. 32(4): 688-693 (2009)]
Yoneda, Kazuhiro, Matsumoto, Ichiro, Sutoh, Fumitaka, Higashi, Ryunosuke, Nunoya, Ken-ichi, Nakade, Susumu, Miyata, Yasuyuki, Ogawa, Mikio
Published in Biological & pharmaceutical bulletin (2009)
Published in Biological & pharmaceutical bulletin (2009)
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ヒト血液脳関門創薬を促進するヒト階層型スフェロイド血液脳関門モデル
降幡, 知巳, 梅原, 健太, 和泉, 沙希, 若山, 直美, 小森, 高文, 伊藤, 涼, 布谷, 憲一, 山浦, 由之, 今若, 治夫, 秋田, 英万, 安西, 尚彦
Published in 日本薬理学会年会要旨集 (2019)
Published in 日本薬理学会年会要旨集 (2019)
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Species Difference in Hydrolysis of an Ester-Type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha‑1 Acid Glycoprotein
Kono, Kenta, Nunoya, Ken-ichi, Nakamura, Yuka, Bi, Jing, Mukunoki, Ayumi, Takeo, Toru, Nakagata, Naomi, Maeda, Hitoshi, Yamaura, Yoshiyuki, Imawaka, Haruo, Watanabe, Hiroshi, Maruyama, Toru
Published in Molecular pharmaceutics (05.09.2022)
Published in Molecular pharmaceutics (05.09.2022)
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A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502)
Nunoya, K, Yokoi, T, Kimura, K, Inoue, K, Kodama, T, Funayama, M, Nagashima, K, Funae, Y, Green, C, Kinoshita, M, Kamataki, T
Published in Pharmacogenetics (London) (01.06.1998)
Published in Pharmacogenetics (London) (01.06.1998)
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The house musk shrew ( Suncus murinus): a unique animal with extremely low level of expression of mRNAs for CYP3A and flavin-containing monooxygenase
Mushiroda, Taisei, Yokoi, Tsuyoshi, Ito, Kunio, Nunoya, Ken-ichi, Nakagawa, Tetsuya, Kubota, Megumi, Takahara, Eiji, Nagata, Osamu, Kato, Hideo, Kamataki, Tetsuya
Published in Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology (01.07.2000)
Published in Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology (01.07.2000)
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