A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers
Smith, Patrick F., Krishnarajah, Janakan, Nunn, Philip A., Hill, Ron J., Karr, Dane, Tam, D., Masjedizadeh, Mohammad, Funk, Jens O., Gourlay, Steve G.
Published in British journal of clinical pharmacology (01.11.2017)
Published in British journal of clinical pharmacology (01.11.2017)
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Phase 1 clinical trial evaluating safety, exposure and pharmacodynamics of BTK inhibitor tolebrutinib (PRN2246, SAR442168)
Owens, Timothy D., Smith, Patrick F., Redfern, Andrew, Xing, Yan, Shu, Jin, Karr, Dane E., Hartmann, Sonja, Francesco, Michelle R., Langrish, Claire L., Nunn, Philip A., Gourlay, Steven G.
Published in Clinical and translational science (01.02.2022)
Published in Clinical and translational science (01.02.2022)
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Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function
Schnegelsberg, Birthe, Sun, Tung-Tien, Cain, Gary, Bhattacharya, Anindya, Nunn, Philip A, Ford, Anthony P D W, Vizzard, Margaret A, Cockayne, Debra A
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.03.2010)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.03.2010)
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Purinoceptors as therapeutic targets for lower urinary tract dysfunction
Ford, Anthony P D W., Gever, Joel R., Nunn, Philip A., Zhong, Yu, Cefalu, Joseph S., Dillon, Michael P., Cockayne, Debra A.
Published in British journal of pharmacology (01.02.2006)
Published in British journal of pharmacology (01.02.2006)
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Conference Proceeding
Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease
Langrish, Claire L, Bradshaw, J Michael, Francesco, Michelle R, Owens, Timothy D, Xing, Yan, Shu, Jin, LaStant, Jacob, Bisconte, Angelina, Outerbridge, Catherine, White, Stephen D, Hill, Ronald J, Brameld, Ken A, Goldstein, David M, Nunn, Philip A
Published in The Journal of immunology (1950) (01.04.2021)
Published in The Journal of immunology (1950) (01.04.2021)
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Prolonged and tunable residence time using reversible covalent kinase inhibitors
Bradshaw, J Michael, McFarland, Jesse M, Paavilainen, Ville O, Bisconte, Angelina, Tam, Danny, Phan, Vernon T, Romanov, Sergei, Finkle, David, Shu, Jin, Patel, Vaishali, Ton, Tony, Li, Xiaoyan, Loughhead, David G, Nunn, Philip A, Karr, Dane E, Gerritsen, Mary E, Funk, Jens Oliver, Owens, Timothy D, Verner, Erik, Brameld, Ken A, Hill, Ronald J, Goldstein, David M, Taunton, Jack
Published in Nature chemical biology (01.07.2015)
Published in Nature chemical biology (01.07.2015)
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The role of metabotropic glutamate receptor mGlu5 in control of micturition and bladder nociception
Hu, Youmin, Dong, Li, Sun, Biying, Guillon, Marlene A., Burbach, Leah R., Nunn, Philip A., Liu, Xingrong, Vilenski, Olga, Ford, Anthony P.D.W., Zhong, Yu, Rong, Weifang
Published in Neuroscience letters (23.01.2009)
Published in Neuroscience letters (23.01.2009)
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Effects of the selective prostacyclin receptor antagonist RO3244019 on the micturition reflex in rats
Cefalu, Joseph S, Zhu, Quan Ming, Eggers, Anne-Christin, Kaan, Timothy K Y, Ho, Meghan J, Jett, Mary-Frances, Cockayne, Debra A, Ford, Anthony P D W, Nunn, Philip A
Published in The Journal of urology (01.12.2007)
Published in The Journal of urology (01.12.2007)
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Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions
Chen, Gang, Panicker, Sandip, Lau, Kai-Yeung, Apparsundaram, Subramaniam, Patel, Vaishali A., Chen, Shiow-Ling, Soto, Rothschild, Jung, Jimmy K.C., Ravindran, Palanikumar, Okuhara, Dayne, Bohnert, Gary, Che, Qinglin, Rao, Patricia E., Allard, John D., Badi, Laura, Bitter, Hans-Marcus, Nunn, Philip A., Narula, Satwant K., DeMartino, Julie A.
Published in Molecular immunology (01.07.2013)
Published in Molecular immunology (01.07.2013)
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Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2 & PRN473 reduces venous thrombosis formation in mice
Smith, Christopher W, Campos, Joana, Brown, Helena C, Jooss, Natalie J, Ivanova, Vanesa-Sindi, Harbi, Maan, Garcia Quintanilla, Lourdes, Jossi, Sian, Perez-Toledo, Marisol, Rookes, Kieran, Brill, Alexander, Theodore, Lindsay N, Owens, Tim, La Stant, Jacob J., Foulke, Matthew C, Mukai, Shin, Francesco, Michelle, Storek, Michael J, Hicks, Alexandra, Langrish, Claire, Nunn, Philip A, Cunningham, Adam F, Chauhan, Abhishek, Thomas, Mark R, Watson, Steve P, Nicolson, Phillip Lindsay Ross
Published in Blood advances (05.07.2024)
Published in Blood advances (05.07.2024)
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Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder
Cefalu, Joseph S, Guillon, Marlene A, Burbach, Leah R, Zhu, Quan-Ming, Hu, Dong-Qing, Ho, Meghan J, Ford, Anthony P D W, Nunn, Philip A, Cockayne, Debra A
Published in The Journal of urology (01.08.2009)
Published in The Journal of urology (01.08.2009)
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Endogenous Purinergic Control of Bladder Activity via Presynaptic P2X3 and P2X2/3 Receptors in the Spinal Cord
Kaan, Timothy K. Y, Yip, Ping K, Grist, John, Cefalu, Joseph S, Nunn, Philip A, Ford, Anthony P. D. W, Zhong, Yu, McMahon, Stephen B
Published in The Journal of neuroscience (24.03.2010)
Published in The Journal of neuroscience (24.03.2010)
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Journal Article
PRN1008, a Reversible Covalent BTK Inhibitor in Clinical Development for Immune Thrombocytopenic Purpura
Langrish, Claire L, Bradshaw, J Michael, Owens, Timothy D, Campbell, Robert L, Francesco, Michelle R, Karr, Dane E, Murray, Steve K, Quesenberry, Robert C, Smith, Patrick F, Taylor, Michael D., Zhu, Jiang, Nunn, Philip A, Gourlay, Steven G
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Endogenous Purinergic Control of Bladder Activity via Presynaptic P2X 3 and P2X 2/3 Receptors in the Spinal Cord
Kaan, Timothy K. Y., Yip, Ping K., Grist, John, Cefalu, Joseph S., Nunn, Philip A., Ford, Anthony P. D. W., Zhong, Yu, McMahon, Stephen B.
Published in The Journal of neuroscience (24.03.2010)
Published in The Journal of neuroscience (24.03.2010)
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Journal Article
Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function
SCHNEGELSBERG, Birthe, SUN, Tung-Tien, CAIN, Gary, BHATTACHARYA, Anindya, NUNN, Philip A, FORD, Anthony P. D. W, VIZZARD, Margaret A, COCKAYNE, Debra A
Published in American journal of physiology. Regulatory, integrative and comparative physiology (2010)
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Published in American journal of physiology. Regulatory, integrative and comparative physiology (2010)
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