Structural basis for therapeutic inhibition of complement C5
Jore, Matthijs M, Johnson, Steven, Sheppard, Devon, Barber, Natalie M, Li, Yang I, Nunn, Miles A, Elmlund, Hans, Lea, Susan M
Published in Nature structural & molecular biology (01.05.2016)
Published in Nature structural & molecular biology (01.05.2016)
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Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury
Garcia, Cristiana C, Weston-Davies, Wynne, Russo, Remo C, Tavares, Luciana P, Rachid, Milene A, Alves-Filho, José C, Machado, Alexandre V, Ryffel, Bernhard, Nunn, Miles A, Teixeira, Mauro M
Published in PloS one (16.05.2013)
Published in PloS one (16.05.2013)
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Successful treatment of a PNH patient non‐responsive to eculizumab with the novel complement C5 inhibitor coversin (nomacopan)
Schols, Saskia, Nunn, Miles A., Mackie, Ian, Weston‐Davies, Wynne, Nishimura, Jun‐ichi, Kanakura, Yuzuru, Blijlevens, Nicole, Muus, Petra, Langemeijer, Saskia
Published in British journal of haematology (01.01.2020)
Published in British journal of haematology (01.01.2020)
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Evaluation of Nomacopan for Treatment of Bullous Pemphigoid: A Phase 2a Nonrandomized Controlled Trial
Sadik, Christian D, Rashid, Hanan, Hammers, Christoph M, Diercks, Gilles F H, Weidinger, Anke, Beissert, Stefan, Schauer, Franziska, Fettiplace, James, Thaçi, Diamant, Ngai, Yenting, Nunn, Miles A, Zillikens, Detlef, Horváth, Barbara
Published in JAMA dermatology (Chicago, Ill.) (01.06.2022)
Published in JAMA dermatology (Chicago, Ill.) (01.06.2022)
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Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses
Preston, Stephen G, Majtán, Juraj, Kouremenou, Chrisoula, Rysnik, Oliwia, Burger, Lena F, Cabezas Cruz, Alejandro, Chiong Guzman, Maylin, Nunn, Miles A, Paesen, Guido C, Nuttall, Patricia A, Austyn, Jonathan M
Published in PLoS pathogens (01.06.2013)
Published in PLoS pathogens (01.06.2013)
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Immunopathology of terminal complement activation and complement C5 blockade creating a pro‐survival and organ‐protective phenotype in trauma
Yang, Zhangsheng, Nunn, Miles A., Le, Tuan D., Simovic, Milomir O., Edsall, Peter R., Liu, Bin, Barr, Johnny L., Lund, Brian J., Hill‐Pryor, Crystal D., Pusateri, Anthony E., Cancio, Leopoldo C., Li, Yansong
Published in British journal of pharmacology (01.02.2023)
Published in British journal of pharmacology (01.02.2023)
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Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells
Eskandarpour, Malihe, Chen, Yi-Hsing, Nunn, Miles A, Coupland, Sarah E, Weston-Davies, Wynne, Calder, Virginia L
Published in The American journal of pathology (01.02.2021)
Published in The American journal of pathology (01.02.2021)
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Sympatric woodland Myotis bats form tight-knit social groups with exclusive roost home ranges
August, Tom A, Nunn, Miles A, Fensome, Amy G, Linton, Danielle M, Mathews, Fiona
Published in PloS one (30.10.2014)
Published in PloS one (30.10.2014)
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Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice
Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E, Sandanger, Øystein, Nilsson, Per H, Nunn, Miles A, Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E
Published in The Journal of immunology (1950) (01.06.2014)
Published in The Journal of immunology (1950) (01.06.2014)
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Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata
Salát, Jirí, Paesen, Guido C, Rezácová, Pavlína, Kotsyfakis, Michalis, Kovárová, Zuzana, Sanda, Miloslav, Majtán, Juraj, Grunclová, Lenka, Horká, Helena, Andersen, John F, Brynda, Jirí, Horn, Martin, Nunn, Miles A, Kopácek, Petr, Kopecký, Jan, Mares, Michael
Published in Biochemical journal (01.07.2010)
Published in Biochemical journal (01.07.2010)
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Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice
Alrashdi, Ibrahim, Alsubaiyel, Amal, Chan, Michele, Battell, Emma E, Ennaceur, Abdel, Nunn, Miles A, Weston-Davies, Wayne, Chazot, Paul L, Obara, Ilona
Published in Frontiers in pharmacology (08.03.2022)
Published in Frontiers in pharmacology (08.03.2022)
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West Nile virus vector Culex modestus established in southern England
Golding, Nick, Nunn, Miles A, Medlock, Jolyon M, Purse, Bethan V, Vaux, Alexander GC, Schäfer, Stefanie M
Published in Parasites & vectors (09.02.2012)
Published in Parasites & vectors (09.02.2012)
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Dual inhibition of complement factor 5 and leukotriene B4 synergistically suppresses murine pemphigoid disease
Sezin, Tanya, Murthy, Sripriya, Attah, Claudia, Seutter, Malte, Holtsche, Maike M, Hammers, Christoph M, Schmidt, Enno, Meshrkey, Fibi, Mousavi, Sadegh, Zillikens, Detlef, Nunn, Miles A, Sadik, Christian D
Published in JCI insight (08.08.2019)
Published in JCI insight (08.08.2019)
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Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks
Roversi, Pietro, Johnson, Steven, Preston, Stephen G., Nunn, Miles A., Paesen, Guido C., Austyn, Jonathan M., Nuttall, Patricia A., Lea, Susan M.
Published in Scientific reports (22.11.2017)
Published in Scientific reports (22.11.2017)
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Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans
Barratt-Due, Andreas, Thorgersen, Ebbe Billmann, Lindstad, Julie Katrine, Pharo, Anne, Lissina, Olga, Lambris, John D, Nunn, Miles A, Mollnes, Tom Eirik
Published in The Journal of immunology (1950) (01.11.2011)
Published in The Journal of immunology (1950) (01.11.2011)
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Journal Article
Structure of and influence of a tick complement inhibitor on human complement component 5
Sottrup-Jensen, Lars, Jenner, Lasse, Pedersen, Jan S, Fredslund, Folmer, Laursen, Nick S, Roversi, Pietro, Andersen, Gregers R, Discipio, Richard, Nunn, Miles A, Oliveira, Cristiano L P, Lea, Susan M
Published in Nature immunology (01.07.2008)
Published in Nature immunology (01.07.2008)
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