A method for estimating the risk of drug-induced phototoxicity and its application to smoothened inhibitors
Peukert, Stefan, Nunez, Jill, He, Feng, Dai, Miao, Yusuff, Naeem, DiPesa, Alan, Miller-Moslin, Karen, Karki, Rajesh, Lagu, Bharat, Harwell, Chris, Zhang, Yalin, Bauer, Daniel, Kelleher, Joseph F., Egan, William
Published in MedChemComm (01.10.2011)
Published in MedChemComm (01.10.2011)
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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
Tria, George S, Abrams, Tinya, Baird, Jason, Burks, Heather E, Firestone, Brant, Gaither, L. Alex, Hamann, Lawrence G, He, Guo, Kirby, Christina A, Kim, Sunkyu, Lombardo, Franco, Macchi, Kaitlin J, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Springer, Clayton, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Yu, Bing, Tiong-Yip, Choi-Lai, Peukert, Stefan
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer
Burks, Heather E, Abrams, Tinya, Kirby, Christina A, Baird, Jason, Fekete, Alexander, Hamann, Lawrence G, Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Peukert, Stefan
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha plus Breast Cancer
Burks, Heather E., Abrams, Tinya, Kirby, Christina A., Baird, Jason, Fekete, Alexander, Hamann, Lawrence G., Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P., Mishina, Yuji, Norris, John D., Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M., Wang, Chunrong, Wang, Jianling, Peukert, Stefan
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders
Bonazzi, Simone, Goold, Carleton P, Gray, Audrey, Thomsen, Noel M, Nunez, Jill, Karki, Rajeshri G, Gorde, Aakruti, Biag, Jonathan D, Malik, Hasnain A, Sun, Yingchuan, Liang, Guiqing, Lubicka, Danuta, Salas, Sarah, Labbe-Giguere, Nancy, Keaney, Erin P, McTighe, Stephanie, Liu, Shanming, Deng, Lin, Piizzi, Grazia, Lombardo, Franco, Burdette, Doug, Dodart, Jean-Cosme, Wilson, Christopher J, Peukert, Stefan, Curtis, Daniel, Hamann, Lawrence G, Murphy, Leon O
Published in Journal of medicinal chemistry (13.02.2020)
Published in Journal of medicinal chemistry (13.02.2020)
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Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC
Piizzi, Grazia, Parker, David T, Peng, Yunshan, Dobler, Markus, Patnaik, Anup, Wattanasin, Som, Liu, Eugene, Lenoir, Francois, Nunez, Jill, Kerrigan, John, McKenney, David, Osborne, Colin, Yu, Donghui, Lanieri, Leanne, Bojkovic, Jade, Dzink-Fox, JoAnn, Lilly, Maria-Dawn, Sprague, Elizabeth R, Lu, Yipin, Wang, Hongming, Ranjitkar, Srijan, Xie, Lili, Wang, Bing, Glick, Meir, Hamann, Lawrence G, Tommasi, Ruben, Yang, Xia, Dean, Charles R
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes
Bonazzi, Simone, Gray, Audrey, Thomsen, Noel M., Biag, Jonathan, Labbe-Giguere, Nancy, Keaney, Erin P., Malik, Hasnain A., Sun, Yingchuan, Nunez, Jill, Karki, Rajeshri G., Knapp, Mark, Elling, Robert, Fuller, John, Pardee, Gwynn, Craig, Lucas, Capre, Ketthsy, Salas, Sarah, Gorde, Aakruti, Liang, Guiqing, Lubicka, Danuta, McTighe, Stephanie M., Goold, Carleton, Liu, Shanming, Deng, Lin, Hong, Jin, Fekete, Alexander, Stadelmann, Pascal, Frieauff, Wilfried, Elhajouji, Azeddine, Bauer, Daniel, Lerchner, Andreas, Radetich, Branko, Furet, Pascal, Piizzi, Grazia, Burdette, Doug, Wilson, Christopher J., Peukert, Stefan, Hamann, Lawrence G., Murphy, Leon O., Curtis, Daniel
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Discovery of 2‑Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists
Peukert, Stefan, Hughes, Richard, Nunez, Jill, He, Guo, Yan, Zhao, Jain, Rishi, Llamas, Luis, Luchansky, Sarah, Carlson, Adam, Liang, Guiqing, Kunjathoor, Vidya, Pietropaolo, Mike, Shapiro, Jeffrey, Castellana, Anja, Wu, Xiaoping, Bose, Avirup
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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Piperazine Sulfonamides as Potent, Selective, and Orally Available 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors with Efficacy in the Rat Cortisone-Induced Hyperinsulinemia Model
Xiang, Jason, Wan, Zhao-Kui, Li, Huan-Qiu, Ipek, Manus, Binnun, Eva, Nunez, Jill, Chen, Lihren, McKew, John C, Mansour, Tarek S, Xu, Xin, Suri, Vipin, Tam, May, Xing, Yuzhe, Li, Xiangping, Hahm, Seung, Tobin, James, Saiah, Eddine
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
LEE, Katherine L, BEHNKE, Mark L, SHEN, Marina W. H, RAMARAO, Manjunath K, GOODWIN, Debra G, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, CLARK, James D, MCKEW, John C, FOLEY, Megan A, CHEN, Lihren, WEIHENG WANG, VARGAS, Richard, NUNEZ, Jill, TAM, Steve, MOLLOVA, Nevena, XIN XU
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS
YU BING, HE GUO, NUNEZ JILL, SPRINGER CLAYTON, DECHANTSREITER MICHAEL A, SUN YINGCHUAN, PEUKERT STEFAN, BURKS HEATHER ELIZABETH, THOMSEN NOEL MARIE FRANCE, TRIA GEORGE SCOTT
Year of Publication 23.10.2015
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Year of Publication 23.10.2015
Patent
Johnson STEAM Academy Magnet School, Cedar Rapids, Iowa, USA
Eichhorn, Katie, Gilbert, Kathy, Hall, Myra, Lawyer, Gretchen, Nunez, Jill
Published in Research-publishing.net (09.05.2022)
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Published in Research-publishing.net (09.05.2022)
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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
Lee, Katherine L., Behnke, Mark L., Foley, Megan A., Chen, Lihren, Wang, Weiheng, Vargas, Richard, Nunez, Jill, Tam, Steve, Mollova, Nevena, Xu, Xin, Shen, Marina W.H., Ramarao, Manjunath K., Goodwin, Debra G., Nickerson-Nutter, Cheryl L., Abraham, William M., Williams, Cara, Clark, James D., McKew, John C.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer
Burks, Heather E, Abrams, Tinya, Kirby, Christina A, Baird, Jason, Fekete, Alexander, Hamann, Lawrence G, Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Peukert, Stefan
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model
Xiang, Jason, Wan, Zhao-Kui, Li, Huan-Qiu, Ipek, Manus, Binnun, Eva, Nunez, Jill, Chen, Lihren, McKew, John C, Mansour, Tarek S, Xu, Xin, Suri, Vipin, Tam, May, Xing, Yuzhe, Li, Xiangping, Hahm, Seung, Tobin, James, Saiah, Eddine
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Journal Article
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy
Lee, Katherine L, Behnke, Mark L, Foley, Megan A, Chen, Lihren, Wang, Weiheng, Vargas, Richard, Nunez, Jill, Tam, Steve, Mollova, Nevena, Xu, Xin, Shen, Marina W H, Ramarao, Manjunath K, Goodwin, Debra G, Nickerson-Nutter, Cheryl L, Abraham, William M, Williams, Cara, Clark, James D, McKew, John C
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Published in Bioorganic & medicinal chemistry (01.02.2008)
Journal Article
BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS
SPRINGER, CLAYTON, YU, BING, BURKS, HEATHER ELIZABETH, TRIA, GEORGE SCOTT, DECHANTSREITER, MICHAEL A, THOMSEN, NOEL MARIE-FRANCE, NUNEZ, JILL, SUN, YINGCHUAN, HE, GUO, PEUKERT, STEFAN
Year of Publication 09.03.2021
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Year of Publication 09.03.2021
Patent