A sphingosine‐1‐phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration
Yamamoto, Rie, Aoki, Tomohiro, Koseki, Hirokazu, Fukuda, Miyuki, Hirose, Jun, Tsuji, Keiichi, Takizawa, Katsumi, Nakamura, Shinichiro, Miyata, Haruka, Hamakawa, Nozomu, Kasuya, Hidetoshi, Nozaki, Kazuhiko, Hirayama, Yoshitaka, Aramori, Ichiro, Narumiya, Shuh
Published in British journal of pharmacology (01.07.2017)
Published in British journal of pharmacology (01.07.2017)
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Journal Article
P3-58 AS1069562, (+)-isomer of indeloxazine, but not duloxetine has curative-like analgesic effect in rat model of streptozotocin-induced diabetic neuropathy
Nobuhito Murai, Toshiaki Aoki, Seiji Tamura, Hiroko Yamamoto, Nozomu Hamakawa, Aishi Kimoto, Yasuhisa Furuichi, Nobuya Matsuoka
Published in Journal of Pharmacological Sciences (15.03.2013)
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Published in Journal of Pharmacological Sciences (15.03.2013)
Journal Article
Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research
Tabata, Kenji, Hamakawa, Nozomu, Sanoh, Seigo, Terashita, Shigeyuki, Teramura, Toshio
Published in European journal of drug metabolism and pharmacokinetics (01.04.2009)
Published in European journal of drug metabolism and pharmacokinetics (01.04.2009)
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Journal Article
Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor
Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Sugano, Yukihito, Yamaki, Susumu, Moritomo, Ayako, Kubo, Satoshi, Nakamura, Koji, Yamagami, Kaoru, Hamakawa, Nozomu, Yokoo, Koji, Fukahori, Hidehiko
Published in Bioorganic & medicinal chemistry (07.08.2018)
Published in Bioorganic & medicinal chemistry (07.08.2018)
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Journal Article
Replacement of mycophenolate mofetil with a JAK inhibitor, AS2553627, in combination with low-dose tacrolimus, for renal allograft rejection in non-human primates
Nakamura, Koji, Oshima, Shinsuke, Maeda, Masashi, Morio, Hiroki, Fukahori, Hidehiko, Nakanishi, Tomonori, Tsujimoto, Susumu, Hirose, Jun, Noto, Takahisa, Hamakawa, Nozomu, Inami, Masamichi, Morokata, Tatsuaki
Published in International immunopharmacology (01.11.2018)
Published in International immunopharmacology (01.11.2018)
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Journal Article
AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover
Murai, Nobuhito, Aoki, Toshiaki, Tamura, Seiji, Sekizawa, Toshihiro, Kakimoto, Shuichiro, Tsukamoto, Mina, Oe, Tomoya, Enomoto, Ryugo, Hamakawa, Nozomu, Matsuoka, Nobuya
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2014)
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Journal Article
AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy
Murai, Nobuhito, Aoki, Toshiaki, Tamura, Seiji, Yamamoto, Hiroko, Hamakawa, Nozomu, Matsuoka, Nobuya
Published in Neuropharmacology (01.04.2014)
Published in Neuropharmacology (01.04.2014)
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Journal Article
P4‐169: Real‐time Microdialysis for aβ Inhibition And Pk/pd Analysis in A Nonhuman Primate Model: In Vivo Efficacy of a Bace‐1 Inhibitor
Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T., Bilcer, Geoffrey M., Miyake, Akira, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Hey, John A.
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Real-time Microdialysis for aβ Inhibition And Pk/pd Analysis in A Nonhuman Primate Model: In Vivo Efficacy of a Bace-1 Inhibitor
Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T, Bilcer, Geoffrey M, Miyake, Akira, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Hey, John A
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
P3‐298: In vivo efficacy of BACE‐1 inhibitor CTS21166 (ASP1702) in rat CNS compartments
Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T., Bilcer, Geoffrey M., Grove, Carl, Hsu, Henry H., Shitaka, Yoshitsugu, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Tang, Jordan, Ghosh, Arun K., Hey, John A.
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
In vivo efficacy of BACE-1 inhibitor CTS21166 (ASP1702) in rat CNS compartments
Yu, Jeremy, Koelsch, Gerald, Li, Aiqun, Turner, Robert T, Bilcer, Geoffrey M, Grove, Carl, Hsu, Henry H, Shitaka, Yoshitsugu, Hamakawa, Nozomu, Terashita, Shigeyuki, Matsuoka, Nobuya, Tang, Jordan, Ghosh, Arun K, Hey, John A
Published in Alzheimer's & dementia (01.07.2009)
Published in Alzheimer's & dementia (01.07.2009)
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Journal Article
AGENTE PREVENTIVO E/OU TERAPÊUTICO PARA A NEUROPATIA DIABÉTICA
HIROKO YAMAMOTO, TOSHIAKI AOKI, SEIJI TAMURA, NOBUHITO MURAI, NOZOMU HAMAKAWA
Year of Publication 19.08.2014
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Year of Publication 19.08.2014
Patent
METHOD OF PREVENTING AND/OR TREATING DIABETIC NEUROPATHY
MURAI NOBUHITO, YAMAMOTO HIROKO, AOKI TOSHIAKI, TAMURA SEIJI, HAMAKAWA NOZOMU
Year of Publication 24.01.2013
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Year of Publication 24.01.2013
Patent
NOVEL PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
MURAI, NOBUHITO, HAMAKAWA, NOZOMU, TAMURA, SEIJI, YAMAMOTO, HIROKO, AOKI, TOSHIAKI
Year of Publication 07.12.2011
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Year of Publication 07.12.2011
Patent
NOVEL PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
MURAI NOBUHITO, YAMAMOTO HIROKO, AOKI TOSHIAKI, TAMURA SEIJI, HAMAKAWA NOZOMU
Year of Publication 06.05.2010
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Year of Publication 06.05.2010
Patent
NOVEL PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
MURAI NOBUHITO, YAMAMOTO HIROKO, AOKI TOSHIAKI, TAMURA SEIJI, HAMAKAWA NOZOMU
Year of Publication 17.12.2009
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Year of Publication 17.12.2009
Patent
NOVEL PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
MURAI, NOBUHITO, HAMAKAWA, NOZOMU, TAMURA, SEIJI, YAMAMOTO, HIROKO, AOKI, TOSHIAKI
Year of Publication 25.11.2009
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Year of Publication 25.11.2009
Patent
NOVEL PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
MURAI, NOBUHITO, HAMAKAWA, NOZOMU, TAMURA, SEIJI, YAMAMOTO, HIROKO, AOKI, TOSHIAKI
Year of Publication 18.09.2008
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Year of Publication 18.09.2008
Patent
Novel prophylactic and/or therapeutic agent for diabetic neuropathy
HIROKO YAMAMOTO, TOSHIAKI AOKI, SEIJI TAMURA, NOBUHITO MURAI, NOZOMU HAMAKAWA
Year of Publication 18.09.2008
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Year of Publication 18.09.2008
Patent
Novel prophylactic and/or therapeutic agent for diabetic neuropathy
MURAI NOBUHITO, YAMAMOTO HIROKO, AOKI TOSHIAKI, TAMURA SEIJI, HAMAKAWA NOZOMU
Year of Publication 11.07.2012
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Year of Publication 11.07.2012
Patent