Metals in protein structures: a review of their principal features
Harding, Marjorie M., Nowicki, Matthew W., Walkinshaw, Malcolm D.
Published in Crystallography reviews (01.10.2010)
Published in Crystallography reviews (01.10.2010)
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Journal Article
The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site
Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Zhong, Wenhe, Michels, Paul A.M., Auld, Douglas S., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in The Journal of biological chemistry (09.09.2011)
Published in The Journal of biological chemistry (09.09.2011)
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Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation
Soukarieh, Fadi, Nowicki, Matthew W., Bastide, Amandine, Pöyry, Tuija, Jones, Carolyn, Dudek, Kate, Patwardhan, Geetanjali, Meullenet, François, Oldham, Neil J., Walkinshaw, Malcolm D., Willis, Anne E., Fischer, Peter M.
Published in European journal of medicinal chemistry (29.11.2016)
Published in European journal of medicinal chemistry (29.11.2016)
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Development of a fluorescent monoclonal antibody‐based assay to measure the allosteric effects of synthetic peptides on self‐oligomerization of AGR2 protein
Gray, Terry A., Murray, Euan, Nowicki, Matthew W., Remnant, Lucy, Scherl, Alexander, Muller, Petr, Vojtesek, Borek, Hupp, Ted R.
Published in Protein science (01.09.2013)
Published in Protein science (01.09.2013)
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Journal Article
Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model
Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Hannaert, Véronique, Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in The Journal of biological chemistry (23.04.2010)
Published in The Journal of biological chemistry (23.04.2010)
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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase
Morgan, Hugh P, Walsh, Martin J, Blackburn, Elizabeth A, Wear, Martin A, Boxer, Matthew B, Shen, Min, Veith, Henrike, McNae, Iain W, Nowicki, Matthew W, Michels, Paul A M, Auld, Douglas S, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D
Published in Biochemical journal (15.11.2012)
Published in Biochemical journal (15.11.2012)
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Pyruvate kinases have an intrinsic and conserved decarboxylase activity
Zhong, Wenhe, Morgan, Hugh P, Nowicki, Matthew W, McNae, Iain W, Yuan, Meng, Bella, Juraj, Michels, Paul A M, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D
Published in Biochemical journal (01.03.2014)
Published in Biochemical journal (01.03.2014)
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Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3- d]pyrimidines
Jorda, Radek, Sacerdoti-Sierra, Nina, Voller, Jiří, Havlíček, Libor, Kráčalíková, Kateřina, Nowicki, Matthew W., Nasereddin, Abedelmajeed, Kryštof, Vladimír, Strnad, Miroslav, Walkinshaw, Malcolm D., Jaffe, Charles L.
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Journal Article
Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200
Wear, Martin A., Nowicki, Matthew W., Blackburn, Elizabeth A., McNae, Iain W., Walkinshaw, Malcolm D.
Published in FEBS open bio (01.04.2017)
Published in FEBS open bio (01.04.2017)
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Journal Article
High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase
Walker, Roderick G, Thomson, Graeme, Malone, Kirk, Nowicki, Matthew W, Brown, Elaine, Blake, David G, Turner, Nicholas J, Walkinshaw, Malcolm D, Grant, Karen M, Mottram, Jeremy C
Published in PLoS neglected tropical diseases (01.04.2011)
Published in PLoS neglected tropical diseases (01.04.2011)
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Journal Article
Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states
Blackburn, Elizabeth A., Fuad, Fazia A.A., Morgan, Hugh P., Nowicki, Matthew W., Wear, Martin A., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Biochemical and biophysical research communications (25.07.2014)
Published in Biochemical and biophysical research communications (25.07.2014)
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Journal Article
Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis
Nowicki, Matthew W., Tulloch, Lindsay B., Worralll, Liam, McNae, Iain W., Hannaert, Véronique, Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Turner, Nicholas J.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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Journal Article
Crystal Structures of Leishmania mexicana Phosphoglycerate Mutase Suggest a One-Metal Mechanism and a New Enzyme Subclass
Nowicki, Matthew W., Kuaprasert, Buabarn, McNae, Iain W., Morgan, Hugh P., Harding, Marjorie M., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Journal of molecular biology (04.12.2009)
Published in Journal of molecular biology (04.12.2009)
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Journal Article
The First Crystal Structure of Phosphofructokinase from a Eukaryote: Trypanosoma brucei
Martinez-Oyanedel, José, McNae, Iain W., Nowicki, Matthew W., Keillor, Jeffrey W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Published in Journal of molecular biology (02.03.2007)
Published in Journal of molecular biology (02.03.2007)
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Journal Article
Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo
Fuad, Fazia Adyani Ahmad, Fothergill-Gilmore, Linda A, Nowicki, Matthew W, Eades, Lorna J, Morgan, Hugh P, McNae, Iain W, Michels, Paul A M, Walkinshaw, Malcolm D
Published in Metallomics (01.12.2011)
Published in Metallomics (01.12.2011)
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