Effects of low temperature on blood‐to‐plasma ratio measurement
Novak, Jonathan J., Burchett, Woodrow, Di, Li
Published in Biopharmaceutics & drug disposition (01.05.2021)
Published in Biopharmaceutics & drug disposition (01.05.2021)
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Journal Article
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Li, Di, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Journal Article
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
Miners, John O., Rowland, Andrew, Novak, Jonathan J., Lapham, Kimberly, Goosen, Theunis C.
Published in Pharmacology & therapeutics (Oxford) (01.02.2021)
Published in Pharmacology & therapeutics (Oxford) (01.02.2021)
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Journal Article
Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
Eng, Heather, Dantonio, Alyssa L, Kadar, Eugene P, Obach, R Scott, Di, Li, Lin, Jian, Patel, Nandini C, Boras, Britton, Walker, Gregory S, Novak, Jonathan J, Kimoto, Emi, Singh, Ravi Shankar P, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.05.2022)
Published in Drug metabolism and disposition (01.05.2022)
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Journal Article
Evaluation of Fraction Unbound Across 7 Tissues of 5 Species
Ryu, Sangwoo, Tess, David, Chang, George, Keefer, Christopher, Burchett, Woodrow, Steeno, Gregory S., Novak, Jonathan J., Patel, Roshan, Atkinson, Karen, Riccardi, Keith, Di, Li
Published in Journal of pharmaceutical sciences (01.02.2020)
Published in Journal of pharmaceutical sciences (01.02.2020)
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Journal Article
The impact of low temperature on fraction unbound for plasma and tissue
Ryu, Sangwoo, Novak, Jonathan J., Patel, Roshan, Yates, Phillip, Di, Li
Published in Biopharmaceutics & drug disposition (01.11.2018)
Published in Biopharmaceutics & drug disposition (01.11.2018)
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Journal Article
Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity
Achour, Brahim, Dantonio, Alyssa, Niosi, Mark, Novak, Jonathan J, Fallon, John K, Barber, Jill, Smith, Philip C, Rostami-Hodjegan, Amin, Goosen, Theunis C
Published in Drug metabolism and disposition (01.10.2017)
Published in Drug metabolism and disposition (01.10.2017)
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Journal Article
Estimation of the Effect of OAT2-Mediated Active Uptake on Meloxicam Exposure in the Human Liver
Li, Rui, Mathialagan, Sumathy, Novak, Jonathan J., Eng, Heather, Riccardi, Keith, Litchfield, John
Published in The AAPS journal (03.01.2020)
Published in The AAPS journal (03.01.2020)
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Journal Article
Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes
Keefer, Christopher, Chang, George, Carlo, Anthony, Novak, Jonathan J., Banker, Michael, Carey, Jackie, Cianfrogna, Julie, Eng, Heather, Jagla, Caitlin, Johnson, Nathaniel, Jones, Rhys, Jordan, Samantha, Lazzaro, Sarah, Liu, JianHua, Scott Obach, R., Riccardi, Keith, Tess, David, Umland, John, Racich, Jillian, Varma, Manthena, Visswanathan, Ravi, Di, Li
Published in European journal of pharmaceutical sciences (01.12.2020)
Published in European journal of pharmaceutical sciences (01.12.2020)
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Journal Article
Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5′-Diphosphate–Glucuronosyltransferase Enzymes with Reference to Catalytic Activity
Achour, Brahim, Dantonio, Alyssa, Niosi, Mark, Novak, Jonathan J., Al-Majdoub, Zubida M., Goosen, Theunis C., Rostami-Hodjegan, Amin, Barber, Jill
Published in Drug metabolism and disposition (01.06.2018)
Published in Drug metabolism and disposition (01.06.2018)
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Journal Article
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease
Gopalsamy, Ariamala, Aulabaugh, Ann E., Barakat, Amey, Beaumont, Kevin C., Cabral, Shawn, Canterbury, Daniel P., Casimiro-Garcia, Agustin, Chang, Jeanne S., Chen, Ming Z., Choi, Chulho, Dow, Robert L., Fadeyi, Olugbeminiyi O., Feng, Xidong, France, Scott P., Howard, Roger M., Janz, Jay M., Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H., King-Ahmad, Amanda, Knee, Kelly M., Kohrt, Jeffrey T., Limberakis, Chris, Liras, Spiros, Martinez, Carlos A., McClure, Kim F., Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J., O'Connell, Thomas N., Parikh, Mihir D., Piotrowski, David W., Plotnikova, Olga, Robinson, Ralph P., Sahasrabudhe, Parag, Sharma, Raman, Thuma, Benjamin A., Vasa, Dipy, Wei, Liuqing, Wenzel, A. Zane, Withka, Jane M., Xiao, Jun, Yayla, Hatice G.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Journal Article
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Di, Li, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao
Published in Science (American Association for the Advancement of Science) (24.12.2021)
Published in Science (American Association for the Advancement of Science) (24.12.2021)
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Journal Article
Industry standard UGT1A3 probe substrate CDCA: A second look
Novak, Jonathan J., Lin, Jian, Riccardi, Keith, Goosen, Theunis C., Lapham, Kimberly
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Journal Article
Abstract 3260: Potentiation of Type I interferon signaling leads to in vivo efficacy achieved with combination of chemotherapy and the PARP7 inhibitor RBN-2397
Kunii, Kaiko, Song, Jeff J., Zimmerman, Danielle, Liu, Chang, Kuplast-Barr, Kristy G., Novak, Jonathan J., Nayak, Sunaina P., Gozgit, Joseph M., Vasbinder, Melissa M., McEachern, Kristen, Kuntz, Kevin W., Keilhack, Heike, Molina, Jennifer R.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Data Generated by Quantitative LC-MS Proteomics Are Only the Start and Not the Endpoint: Optimization of QconCAT-Based Measurement of Hepatic UDP-Glucuronosyltransferase Enzymes with Reference to Catalytic Activity
Achour, Brahim, Dantonio, Alyssa, Niosi, Mark, Novak, Jonathan J, Al-Majdoub, Zubida M, Goosen, Theunis C, Rostami-Hodjegan, Amin, Barber, Jill
Published in Drug metabolism and disposition (26.03.2018)
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Published in Drug metabolism and disposition (26.03.2018)
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