The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
Vangamudi, Bhavatarini, Paul, Thomas A, Shah, Parantu K, Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S, Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N, Peoples, Mike, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R, Draetta, Giulio, Jones, Philip, Palmer, Wylie S, Sharma, Shikhar, Andersen, Jannik N
Published in Cancer research (Chicago, Ill.) (15.09.2015)
Published in Cancer research (Chicago, Ill.) (15.09.2015)
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Elucidation of cardiovascular effects mediated by blockade of the PI3K/mTOR/Akt pathway using selective inhibitors
Nottebaum, Lisa M., Hemkens, Michelle D., Blasi, Eileen, Selkirk, Julie V., McHarg, Aileen D.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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A novel cell-based assay for G-protein-coupled receptor-mediated cyclic adenosine monophosphate response element binding protein phosphorylation
Selkirk, Julie V, Nottebaum, Lisa M, Ford, Ian C, Santos, Mark, Malany, Siobhan, Foster, Alan C, Lechner, Sandra M
Published in Journal of biomolecular screening (01.06.2006)
Published in Journal of biomolecular screening (01.06.2006)
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Journal Article
Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus
Selkirk, Julie V., Nottebaum, Lisa M., Vana, Alicia M., Verge, Gail M., Mackay, Kenneth B., Stiefel, Theodore H., Naeve, Greg S., Pomeroy, Jordan E., Petroski, Robert E., Moyer, John, Dunlop, John, Foster, Alan C.
Published in The European journal of neuroscience (01.06.2005)
Published in The European journal of neuroscience (01.06.2005)
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Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function
Schwarz, David A., Allen, Molly M., Petroski, Robert E., Pomeroy, Jordan E., Heise, Christopher E., Mistry, Monica S., Selkirk, Julie V., Nottebaum, Lisa M., Grey, Jonathan, Zhang, Mingzhu, Goodfellow, Val S., Maki, Richard A.
Published in Molecular and cellular endocrinology (19.10.2006)
Published in Molecular and cellular endocrinology (19.10.2006)
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Design and Synthesis of gamma- and delta-Lactarn M-1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M-1-Selective PAM with Weak Agonist Activity
Davoren, Jennifer E., Garney, Michelle, Pettersen, Betty, Brodney, Michael A., Edgerton, Jeremy R., Fortin, Jean-Philippe, Grimwood, Sarah, Harris, Anthony R., Jenkinson, Stephen, Kenakin, Terry, Lazzaro, John T., Lee, Che-Wah, Lotarski, Susan M., Nottebaum, Lisa, O'Neil, Steven V., Popiolek, Michael, Ramsey, Simeon, Steyn, Stefanus J., Thorn, Catherine A., Zhang, Lei, Webb, Damien
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Discovery of the Potent and Selective M1 PAM-Agonist N‑[(3R,4S)‑3-Hydroxytetrahydro‑2H‑pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
Davoren, Jennifer E, Lee, Che-Wah, Garnsey, Michelle, Brodney, Michael A, Cordes, Jason, Dlugolenski, Keith, Edgerton, Jeremy R, Harris, Anthony R, Helal, Christopher J, Jenkinson, Stephen, Kauffman, Gregory W, Kenakin, Terrence P, Lazzaro, John T, Lotarski, Susan M, Mao, Yuxia, Nason, Deane M, Northcott, Carrie, Nottebaum, Lisa, O’Neil, Steven V, Pettersen, Betty, Popiolek, Michael, Reinhart, Veronica, Salomon-Ferrer, Romelia, Steyn, Stefanus J, Webb, Damien, Zhang, Lei, Grimwood, Sarah
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Journal Article
Design and Synthesis of γ- and δ‑Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1‑Selective PAM with Weak Agonist Activity
Davoren, Jennifer E, Garnsey, Michelle, Pettersen, Betty, Brodney, Michael A, Edgerton, Jeremy R, Fortin, Jean-Philippe, Grimwood, Sarah, Harris, Anthony R, Jenkinson, Stephen, Kenakin, Terry, Lazzaro, John T, Lee, Che-Wah, Lotarski, Susan M, Nottebaum, Lisa, O’Neil, Steven V, Popiolek, Michael, Ramsey, Simeon, Steyn, Stefanus J, Thorn, Catherine A, Zhang, Lei, Webb, Damien
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Characterization of nonhuman primate aorta as an in vitro model for measuring vasoconstriction and vasorelaxation: Comparison to rat
Nottebaum, Lisa, Bassyouni, Asser, Hemkens, Michelle, Jenkinson, Stephen, Butler, Paul
Published in Journal of pharmacological and toxicological methods (01.07.2013)
Published in Journal of pharmacological and toxicological methods (01.07.2013)
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Journal Article
Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1 -Selective PAM with Weak Agonist Activity
Davoren, Jennifer E, Garnsey, Michelle, Pettersen, Betty, Brodney, Michael A, Edgerton, Jeremy R, Fortin, Jean-Philippe, Grimwood, Sarah, Harris, Anthony R, Jenkinson, Stephen, Kenakin, Terry, Lazzaro, John T, Lee, Che-Wah, Lotarski, Susan M, Nottebaum, Lisa, O'Neil, Steven V, Popiolek, Michael, Ramsey, Simeon, Steyn, Stefanus J, Thorn, Catherine A, Zhang, Lei, Webb, Damien
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Journal Article
Abstract 3528: The SMARCA2/4 catalytic activity, but not the bromodomain, is a drug target in SWI/SNF mutant cancers
Vangamudi, Bhavatarini, Paul, Thomas, Shah, Parantu K., Alimova, Maria K., Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S., Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N., Peoples, Mike, Petrocchi, Alessia, Marszalek, Joseph R., Toniatti, Carlo, Heffernan, Timothy P., Verhelle, Dominique, Draetta, Giulio, Owen, Dafydd, Jones, Philip, Palmer, Wylie, Sharma, Shikhar, Andersen, Jannik N.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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