Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
Karagöz, G. Elif, Duarte, Afonso M.S., Akoury, Elias, Ippel, Hans, Biernat, Jacek, Morán Luengo, Tania, Radli, Martina, Didenko, Tatiana, Nordhues, Bryce A., Veprintsev, Dmitry B., Dickey, Chad A., Mandelkow, Eckhard, Zweckstetter, Markus, Boelens, Rolf, Madl, Tobias, Rüdiger, Stefan G.D.
Published in Cell (27.02.2014)
Published in Cell (27.02.2014)
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Journal Article
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
Abisambra, Jose F, Jinwal, Umesh K, Blair, Laura J, O'Leary, 3rd, John C, Li, Qingyou, Brady, Sarah, Wang, Li, Guidi, Chantal E, Zhang, Bo, Nordhues, Bryce A, Cockman, Matthew, Suntharalingham, Amirthaa, Li, Pengfei, Jin, Ying, Atkins, Christopher A, Dickey, Chad A
Published in The Journal of neuroscience (29.05.2013)
Published in The Journal of neuroscience (29.05.2013)
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Journal Article
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
Blair, Laura J, Nordhues, Bryce A, Hill, Shannon E, Scaglione, K Matthew, O'Leary, 3rd, John C, Fontaine, Sarah N, Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L, Muschol, Martin, Uversky, Vladimir N, Klengel, Torsten, Binder, Elisabeth B, Kayed, Rakez, Golde, Todd E, Berchtold, Nicole, Dickey, Chad A
Published in The Journal of clinical investigation (01.10.2013)
Published in The Journal of clinical investigation (01.10.2013)
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Journal Article
Hsp90 activator Aha1 drives production of pathological tau aggregates
Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.
Published in Proceedings of the National Academy of Sciences - PNAS (05.09.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (05.09.2017)
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Journal Article
Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
Sabbagh, Jonathan J, O'Leary, 3rd, John C, Blair, Laura J, Klengel, Torsten, Nordhues, Bryce A, Fontaine, Sarah N, Binder, Elisabeth B, Dickey, Chad A
Published in PloS one (05.09.2014)
Published in PloS one (05.09.2014)
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Journal Article
Human cyclophilin 40 unravels neurotoxic amyloids
Baker, Jeremy D, Shelton, Lindsey B, Zheng, Dali, Favretto, Filippo, Nordhues, Bryce A, Darling, April, Sullivan, Leia E, Sun, Zheying, Solanki, Parth K, Martin, Mackenzie D, Suntharalingam, Amirthaa, Sabbagh, Jonathan J, Becker, Stefan, Mandelkow, Eckhard, Uversky, Vladimir N, Zweckstetter, Markus, Dickey, Chad A, Koren, 3rd, John, Blair, Laura J
Published in PLoS biology (27.06.2017)
Published in PLoS biology (27.06.2017)
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Journal Article
Imbalance of Hsp70 family variants fosters tau accumulation
Jinwal, Umesh K, Akoury, Elias, Abisambra, Jose F, O'Leary, 3rd, John C, Thompson, Andrea D, Blair, Laura J, Jin, Ying, Bacon, Justin, Nordhues, Bryce A, Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N, Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E, Zweckstetter, Markus, Dickey, Chad A
Published in The FASEB journal (01.04.2013)
Published in The FASEB journal (01.04.2013)
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Journal Article
Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
Stothert, Andrew R, Suntharalingam, Amirthaa, Tang, Xiaolan, Crowley, Vincent M, Mishra, Sanket J, Webster, Jack M, Nordhues, Bryce A, Huard, Dustin J E, Passaglia, Christopher L, Lieberman, Raquel L, Blagg, Brian S J, Blair, Laura J, Koren, 3rd, John, Dickey, Chad A
Published in Scientific reports (20.12.2017)
Published in Scientific reports (20.12.2017)
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Journal Article
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins
Fontaine, Sarah N, Zheng, Dali, Sabbagh, Jonathan J, Martin, Mackenzie D, Chaput, Dale, Darling, April, Trotter, Justin H, Stothert, Andrew R, Nordhues, Bryce A, Lussier, April, Baker, Jeremy, Shelton, Lindsey, Kahn, Mahnoor, Blair, Laura J, Stevens Jr, Stanley M, Dickey, Chad A
Published in The EMBO journal (15.07.2016)
Published in The EMBO journal (15.07.2016)
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Journal Article
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein
Taylor, Isabelle R., Ahmad, Atta, Wu, Taia, Nordhues, Bryce A., Bhullar, Anup, Gestwicki, Jason E., Zuiderweg, Erik R.P.
Published in The Journal of biological chemistry (06.07.2018)
Published in The Journal of biological chemistry (06.07.2018)
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Journal Article
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
Blair, Laura J, Frauen, Haley D, Zhang, Bo, Nordhues, Bryce A, Bijan, Sara, Lin, Yen-Chi, Zamudio, Frank, Hernandez, Lidice D, Sabbagh, Jonathan J, Selenica, Maj-Linda B, Dickey, Chad A
Published in Acta neuropathologica communications (31.01.2015)
Published in Acta neuropathologica communications (31.01.2015)
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Journal Article
The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate
Chatterjee, Srirupa, Zhong, Dalian, Nordhues, Bryce A., Battaile, Kevin P., Lovell, Scott, De Guzman, Roberto N.
Published in Protein science (01.01.2011)
Published in Protein science (01.01.2011)
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Journal Article
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement
Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R.P., Gestwicki, Jason E., Dickey, Chad A.
Published in The Journal of biological chemistry (22.05.2015)
Published in The Journal of biological chemistry (22.05.2015)
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Journal Article
Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD
Sabbagh, Jonathan J, Cordova, Ricardo A, Zheng, Dali, Criado-Marrero, Marangelie, Lemus, Andrea, Li, Pengfei, Baker, Jeremy D, Nordhues, Bryce A, Darling, April L, Martinez-Licha, Carlos, Rutz, Daniel A, Patel, Shreya, Buchner, Johannes, Leahy, James W, Koren, John, Dickey, Chad A, Blair, Laura J
Published in ACS chemical biology (17.08.2018)
Published in ACS chemical biology (17.08.2018)
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Journal Article
The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling
Blair, Laura J, Criado-Marrero, Marangelie, Zheng, Dali, Wang, Xinming, Kamath, Siddharth, Nordhues, Bryce A, Weeber, Edwin J, Dickey, Chad A
Published in eNeuro (01.01.2019)
Published in eNeuro (01.01.2019)
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Journal Article
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
Fontaine, Sarah N, Martin, Mackenzie D, Akoury, Elias, Assimon, Victoria A, Borysov, Sergiy, Nordhues, Bryce A, Sabbagh, Jonathan J, Cockman, Matt, Gestwicki, Jason E, Zweckstetter, Markus, Dickey, Chad A
Published in Human molecular genetics (15.07.2015)
Published in Human molecular genetics (15.07.2015)
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Journal Article
Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis
Selenica, Maj-Linda B, Davtyan, Hayk, Housley, Steven B, Blair, Laura J, Gillies, Anne, Nordhues, Bryce A, Zhang, Bo, Liu, Joseph, Gestwicki, Jason E, Lee, Daniel C, Gordon, Marcia N, Morgan, Dave, Dickey, Chad A
Published in Journal of neuroinflammation (03.09.2014)
Published in Journal of neuroinflammation (03.09.2014)
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Journal Article
Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules
Martin, Mackenzie D, Baker, Jeremy D, Suntharalingam, Amirthaa, Nordhues, Bryce A, Shelton, Lindsey B, Zheng, Dali, Sabbagh, Jonathan J, Haystead, Timothy A.J, Gestwicki, Jason E, Dickey, Chad A
Published in ACS chemical biology (15.07.2016)
Published in ACS chemical biology (15.07.2016)
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