In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
Wienen, Wolfgang, Stassen, Jean-Marie, Priepke, Henning, Ries, Uwe Joerg, Hauel, Norbert
Published in Thrombosis and haemostasis (01.07.2007)
Published in Thrombosis and haemostasis (01.07.2007)
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Journal Article
Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors
Hauel, Norbert H, Nar, Herbert, Priepke, Henning, Ries, Uwe, Stassen, Jean-Marie, Wienen, Wolfgang
Published in Journal of medicinal chemistry (25.04.2002)
Published in Journal of medicinal chemistry (25.04.2002)
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Journal Article
Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats
Wienen, Wolfgang, Stassen, Jean-Marie, Priepke, Henning, Ries, Uwe Joerg, Hauel, Norbert
Published in Thrombosis and haemostasis (01.08.2007)
Published in Thrombosis and haemostasis (01.08.2007)
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Journal Article
Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate
Pascolo, Emanuelle, Wenz, Christian, Lingner, Joachim, Hauel, Norbert, Priepke, Henning, Kauffmann, Iris, Garin-Chesa, Pilar, Rettig, Wolfgang J., Damm, Klaus, Schnapp, Andreas
Published in The Journal of biological chemistry (03.05.2002)
Published in The Journal of biological chemistry (03.05.2002)
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Journal Article
Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents
Ries, Uwe J., Priepke, Henning W.M., Hauel, Norbert H., Handschuh, Sandra, Mihm, Gerhard, Stassen, Jean M., Wienen, Wolfgang, Nar, Herbert
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors
Nar, Herbert, Bauer, Margit, Schmid, Angela, Stassen, Jean-Marie, Wienen, Wolfgang, Priepke, Henning W.M, Kauffmann, Iris K, Ries, Uwe J, Hauel, Norbert H
Published in Structure (London) (10.01.2001)
Published in Structure (London) (10.01.2001)
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Journal Article
6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships
Ries, Uwe J, Mihm, Gerhard, Narr, Berthold, Hasselbach, Kai M, Wittneben, Helmut, Entzeroth, Michael, van Meel, Jacobus C. A, Wienen, Wolfgang, Hauel, Norbert H
Published in Journal of medicinal chemistry (10.12.1993)
Published in Journal of medicinal chemistry (10.12.1993)
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Journal Article
Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives
Ries, Uwe J., Priepke, Henning W.M., Hauel, Norbert H., Haaksma, Eric E.J., Stassen, Jean M., Wienen, Wolfgang, Nar, Herbert
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
The discovery of dabigatran etexilate
van Ryn, Joanne, Goss, Ashley, Hauel, Norbert, Wienen, Wolfgang, Priepke, Henning, Nar, Herbert, Clemens, Andreas
Published in Frontiers in pharmacology (01.01.2013)
Published in Frontiers in pharmacology (01.01.2013)
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Journal Article
A highly selective telomerase inhibitor limiting human cancer cell proliferation
Damm, Klaus, Hemmann, Ulrike, Garin-Chesa, Pilar, Hauel, Norbert, Kauffmann, Iris, Priepke, Henning, Niestroj, Claudia, Daiber, Christine, Enenkel, Barbara, Guilliard, Bernd, Lauritsch, Ines, Müller, Elfriede, Pascolo, Emanuelle, Sauter, Gabriele, Pantic, Milena, Martens, Uwe M., Wenz, Christian, Lingner, Joachim, Kraut, Norbert, Rettig, Wolfgang J., Schnapp, Andreas
Published in The EMBO journal (17.12.2001)
Published in The EMBO journal (17.12.2001)
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Journal Article
3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors
Eckhardt, Matthias, Hauel, Norbert, Himmelsbach, Frank, Langkopf, Elke, Nar, Herbert, Mark, Michael, Tadayyon, Moh, Thomas, Leo, Guth, Brian, Lotz, Ralf
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5- d]pyridazin-4-one and their selective elaboration
Eckhardt, Matthias, Hauel, Norbert, Langkopf, Elke, Himmelsbach, Frank
Published in Tetrahedron letters (17.03.2008)
Published in Tetrahedron letters (17.03.2008)
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Journal Article
Comparison of the Antithrombotic Effectiveness of the Direct Thrombin Inhibitor, Dabigatran Etexilate, and Two Factor Xa Inhibitors in an A-V Shunt Model of Thrombosis in Rabbits
van Ryn, Joanne, Hauel, Norbert, Priepke, Henning, Gerlach, Kai, Schuler-Metz, Annette, Wienen, Wolfgang
Published in Blood (16.11.2007)
Published in Blood (16.11.2007)
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Journal Article
Effects of Dabigatran, a Direct Thrombin Inhibitor, as Compared to the Direct Factor Xa Inhibitors, Rivaroxaban and Apixaban, on Tissue Factor-Induced Human Platelet Aggregation in Platelet Rich Plasma
van Ryn, Joanne, Kink-Eiband, Monika, Hauel, Norbert, Priepke, Henning, Wienen, Wolfgang
Published in Blood (16.11.2007)
Published in Blood (16.11.2007)
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Journal Article
Dabigatran Inhibits Arterial Thrombosis in a Porcine Model of Cyclic Flow Reduction
van Ryn, Joanne, Priepke, Henning, Ries, Uwe J., Hauel, Norbert, Stassen, Jean-Marie, Wienen, Wolfgang
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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