Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Sivaprakasam, Prasanna, Han, Xiaojun, Civiello, Rita L., Jacutin-Porte, Swanee, Kish, Kevin, Pokross, Matt, Lewis, Hal A., Ahmed, Nazia, Szapiel, Nicolas, Newitt, John A., Baldwin, Eric T., Xiao, Hong, Krause, Carol M., Park, Hyunsoo, Nophsker, Michelle, Lippy, Jonathan S., Burton, Catherine R., Langley, David R., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A
Sun, Jin-Hua, O'Boyle, 2nd, Donald R, Fridell, Robert A, Langley, David R, Wang, Chunfu, Roberts, Susan B, Nower, Peter, Johnson, Benjamin M, Moulin, Frederic, Nophsker, Michelle J, Wang, Ying-Kai, Liu, Mengping, Rigat, Karen, Tu, Yong, Hewawasam, Piyasena, Kadow, John, Meanwell, Nicholas A, Cockett, Mark, Lemm, Julie A, Kramer, Melissa, Belema, Makonen, Gao, Min
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
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A polychromatic turbidity microplate assay to distinguish discovery stage drug molecules with beneficial precipitation properties
Morrison, John, Nophsker, Michelle, Elzinga, Paul, Donoso, Maria, Park, Hyunsoo, Haskell, Roy
Published in International journal of pharmaceutics (05.10.2017)
Published in International journal of pharmaceutics (05.10.2017)
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BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
Marcin, Lawrence R, Warrier, Jayakumar, Thangathirupathy, Srinivasan, Shi, Jianliang, Karageorge, George N, Pearce, Bradley C, Ng, Alicia, Park, Hyunsoo, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Reddy, Aliphedi B, Nagaraju, G, Tonukunuru, Gopikishan, Gupta, Grandhi V. R. K. M, Kamble, Manjunatha, Mannoori, Raju, Cheruku, Srinivas, Jogi, Srinivas, Gulia, Jyoti, Bastia, Tanmaya, Sanmathi, Charulatha, Aher, Jayant, Kallem, Rajareddy, Srikumar, Bettadapura N, Vijaya, Kumar Kuchibhotla, Naidu, Pattipati S, Paschapur, Mahesh, Kalidindi, Narasimharaju, Vikramadithyan, Reeba, Ramarao, Manjunath, Denton, Rex, Molski, Thaddeus, Shields, Eric, Subramanian, Murali, Zhuo, Xiaoliang, Nophsker, Michelle, Simmermacher, Jean, Sinz, Michael, Albright, Charlie, Bristow, Linda J, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, King, Dalton, Thompson, Lorin A, Macor, John E
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors
Alt, Andrew, Pendri, Annapurna, Bertekap, Jr, Robert L, Li, Guo, Benitex, Yulia, Nophsker, Michelle, Rockwell, Kristin L, Burford, Neil T, Sum, Chi Shing, Chen, Jing, Herbst, John J, Ferrante, Meredith, Hendricson, Adam, Cvijic, Mary Ellen, Westphal, Ryan S, O'Connell, Jonathan, Banks, Martyn, Zhang, Litao, Gentles, Robert G, Jenkins, Susan, Loy, James, Macor, John E
Published in The Journal of pharmacology and experimental therapeutics (01.02.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2016)
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