The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
GRIMM, Scott W, EINOLF, Heidi J, TONN, George R, VAN HORN, Robert, WANG, Regina W, WONG, Y. Nancy, YANG, Tian J, OBACH, R. Scott, HALL, Steven D, KAN HE, LIM, Heng-Keang, LING, Kah-Hiing John, CHUANG LU, NOMEIR, Amin A, SEIBERT, Eleanore, SKORDOS, Konstantine W
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
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Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice
Reich, Eva‐Pia, Cui, Long, Yang, Lily, Pugliese‐Sivo, Catherine, Golovko, Andrei, Petro, Mary, Vassileva, Galya, Chu, Inhou, Nomeir, Amin A., Zhang, Li‐Kang, Liang, Xian, Kozlowski, Joseph A., Narula, Satwant K., Zavodny, Paul J., Chou, Chuan‐Chu
Published in European journal of immunology (01.04.2005)
Published in European journal of immunology (01.04.2005)
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Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery
Nomeir, Amin A., Morrison, Richard, Prelusky, Daniel, Korfmacher, Walter, Broske, Lisa, Hesk, David, McNamara, Paul, Mei, Hong
Published in Journal of pharmaceutical sciences (01.11.2009)
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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity
Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.
Published in ChemMedChem (01.12.2013)
Published in ChemMedChem (01.12.2013)
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Higher-throughput screening for Caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system
Fung, Eliza N., Chu, Inhou, Li, Cheng, Liu, Tongtong, Soares, Anthony, Morrison, Richard, Nomeir, Amin A.
Published in Rapid communications in mass spectrometry (01.01.2003)
Published in Rapid communications in mass spectrometry (01.01.2003)
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In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects
Cohen-Williams, Mary E., Leach, Prescott T., Del Vecchio, Robert A., Zhang, Qi, Hyde, Lynn A., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.
Published in Interdisciplinary perspectives on infectious diseases (2013)
Published in Interdisciplinary perspectives on infectious diseases (2013)
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High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma
Kim, Hong, Likhari, Paul, Parker, Donald, Statkevich, Paul, Marco, Aliceann, Lin, Chin-Chung, Nomeir, Amin A.
Published in Journal of pharmaceutical and biomedical analysis (2001)
Published in Journal of pharmaceutical and biomedical analysis (2001)
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Use of high-performance liquid chromatographic and microbiological analyses for evaluating the presence or absence of active metabolites of the antifungal posaconazole in human plasma
Kim, Hong, Kumari, Pramila, Laughlin, Mark, Hilbert, Mary Jane, Indelicato, Stephen R, Lim, Josephine, Lin, Chin-Chung, Nomeir, Amin A
Published in Journal of Chromatography A (14.02.2003)
Published in Journal of Chromatography A (14.02.2003)
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Inhibition of CYP3A4 in a Rapid Microtiter Plate Assay Using Recombinant Enzyme and in Human Liver Microsomes Using Conventional Substrates
NOMEIR, Amin A, RUEGG, Charles, SHOEMAKER, Matthew, FAVREAU, Leonard V, PALAMANDA, Jairam R, SILBER, Paul, LIN, Chin-Chung
Published in Drug metabolism and disposition (01.05.2001)
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Published in Drug metabolism and disposition (01.05.2001)
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Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions
Shue, Ho-Jane, Chen, Xiao, Schwerdt, John H, Paliwal, Sunil, Blythin, David J, Lin, Ling, Gu, Danlin, Wang, Cheng, Reichard, Gregory A, Wang, Hongwu, Piwinski, John J, Duffy, Ruth A, Lachowicz, Jean E, Coffin, Vicki L, Nomeir, Amin A, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects
Hyde, Lynn A., Zhang, Qi, Del Vecchio, Robert A., Leach, Prescott T., Cohen-Williams, Mary E., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.
Published in International journal of alzheimer's disease (2013)
Published in International journal of alzheimer's disease (2013)
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Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys
NOMEIR, A. A, KUMARI, P, HILBERT, M. J, GUPTA, S, LOEBENBERG, D, CACCIAPUOTI, A, HARE, R, MILLER, G. H, LIN, C.-C, CAYEN, M. N
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)
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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases
Paruch, Kamil, Dwyer, Michael P, Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J, Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry, Hruza, Alan, Madison, Vincent, Nomeir, Amin A, Wang, Yaolin, Kirschmeier, Paul, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Frances, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A, Paradkar, Vidyadhar M, Park, Haengsoon, Rokosz, Laura R, Stauffer, Tara M, Guzi, Timothy J
Published in ACS medicinal chemistry letters (12.08.2010)
Published in ACS medicinal chemistry letters (12.08.2010)
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Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors
Dwyer, Michael P., Keertikar, Kerry M., Chen, Lei, Tong, Ling, Selyutin, Oleg, Nair, Anilkumar G., Yu, Wensheng, Zhou, Guowei, Lavey, Brian J., Yang, De-Yi, Wong, Michael, Kim, Seong Heon, Coburn, Craig A., Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Shankar, Bandarpalle B., Rizvi, Razia, Nomeir, Amin A., Liu, Rong, Agrawal, Sony, Xia, Ellen, Kong, Rong, Zhai, Ying, Ingravallo, Paul, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
Published in Bioorganic & medicinal chemistry letters (15.08.2016)
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Protein binding-dependent decreases in hERG channel blocker potency assessed by whole-cell voltage clamp in serum
Margulis, Michael, Sorota, Steve, Chu, Inhou, Soares, Anthony, Priestley, Tony, Nomeir, Amin A
Published in Journal of cardiovascular pharmacology (01.04.2010)
Published in Journal of cardiovascular pharmacology (01.04.2010)
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New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents
Zhu, Hugh Y., Desai, Jagdish, Cooper, Alan B., Wang, James, Rane, Dinananth F., Kirschmeier, Paul, Strickland, Corey, Liu, Ming, Nomeir, Amin A., Girijavallabhan, Viyyoor M.
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
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Design, synthesis, and structure–activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors
Li, Hongmei, Xu, Ruo, Cole, David, Clader, John W., Greenlee, William J., Nomeir, Amin A., Song, Lixin, Zhang, Lili
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Validation of a rapid microtiter plate assay to conduct cytochrome P450 2D6 enzyme inhibition studies
Palamanda, Jairam R, Favreau, Leonard, Lin, Chin-chung, Nomeir, Amin A
Published in Drug discovery today (01.10.1998)
Published in Drug discovery today (01.10.1998)
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