iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity
Nobles, Christopher L, Reddy, Shantan, Salas-McKee, January, Liu, Xiaojun, June, Carl H, Melenhorst, J Joseph, Davis, Megan M, Zhao, Yangbing, Bushman, Frederic D
Published in Genome Biology (17.01.2019)
Published in Genome Biology (17.01.2019)
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Journal Article
A more efficient CRISPR-Cas12a variant derived from Lachnospiraceae bacterium MA2020
Tran, Mai H., Park, Hajeung, Nobles, Christopher L., Karunadharma, Pabalu, Pan, Li, Zhong, Guocai, Wang, Haimin, He, Wenhui, Ou, Tianling, Crynen, Gogce, Sheptack, Kelly, Stiskin, Ian, Mou, Huihui, Farzan, Michael
Published in Molecular therapy. Nucleic acids (04.06.2021)
Published in Molecular therapy. Nucleic acids (04.06.2021)
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Journal Article
A product of heme catabolism modulates bacterial function and survival
Nobles, Christopher L, Green, Sabrina I, Maresso, Anthony W
Published in PLoS pathogens (01.07.2013)
Published in PLoS pathogens (01.07.2013)
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Journal Article
Hal Is a Bacillus anthracis Heme Acquisition Protein
Balderas, Miriam A, Nobles, Christopher L, Honsa, Erin S, Alicki, Embriette R, Maresso, Anthony W
Published in Journal of Bacteriology (01.10.2012)
Published in Journal of Bacteriology (01.10.2012)
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Journal Article
Assessment of HIV-1 integration in tissues and subsets across infection stages
Wu, Vincent H, Nobles, Christopher L, Kuri-Cervantes, Leticia, McCormick, Kevin, Everett, John K, Nguyen, Son, Del Rio Estrada, Perla M, González-Navarro, Mauricio, Torres-Ruiz, Fernanda, Ávila-Ríos, Santiago, Reyes-Terán, Gustavo, Bushman, Frederic D, Betts, Michael R
Published in JCI insight (15.10.2020)
Published in JCI insight (15.10.2020)
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Journal Article
Decade-long leukaemia remissions with persistence of CD4 + CAR T cells
Melenhorst, J Joseph, Chen, Gregory M, Wang, Meng, Porter, David L, Chen, Changya, Collins, McKensie A, Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L, Maji, Sayantan, Frey, Noelle V, Gill, Saar I, Loren, Alison W, Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E, Davis, Megan M, Fraietta, Joseph A, Brogdon, Jennifer L, Young, Regina M, Chew, Anne, Levine, Bruce L, Siegel, Donald L, Alanio, Cécile, Wherry, E John, Bushman, Frederic D, Lacey, Simon F, Tan, Kai, June, Carl H
Published in Nature (London) (17.02.2022)
Published in Nature (London) (17.02.2022)
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Journal Article
CRISPR-engineered T cells in patients with refractory cancer
Stadtmauer, Edward A, Fraietta, Joseph A, Davis, Megan M, Cohen, Adam D, Weber, Kristy L, Lancaster, Eric, Mangan, Patricia A, Kulikovskaya, Irina, Gupta, Minnal, Chen, Fang, Tian, Lifeng, Gonzalez, Vanessa E, Xu, Jun, Jung, In-Young, Melenhorst, J Joseph, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Gaymon, Avery L, Desjardins, Stephanie, Lamontagne, Anne, Salas-Mckee, January, Fesnak, Andrew, Siegel, Donald L, Levine, Bruce L, Jadlowsky, Julie K, Young, Regina M, Chew, Anne, Hwang, Wei-Ting, Hexner, Elizabeth O, Carreno, Beatriz M, Nobles, Christopher L, Bushman, Frederic D, Parker, Kevin R, Qi, Yanyan, Satpathy, Ansuman T, Chang, Howard Y, Zhao, Yangbing, Lacey, Simon F, June, Carl H
Published in Science (American Association for the Advancement of Science) (28.02.2020)
Published in Science (American Association for the Advancement of Science) (28.02.2020)
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Journal Article
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Fraietta, Joseph A, Nobles, Christopher L, Sammons, Morgan A, Lundh, Stefan, Carty, Shannon A, Reich, Tyler J, Cogdill, Alexandria P, Morrissette, Jennifer J D, DeNizio, Jamie E, Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John K, Alexander, Katherine A, Lin-Shiao, Enrique, Gee, Marvin H, Liu, Xiaojun, Young, Regina M, Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha S, Marcucci, Katherine T, Levine, Bruce L, Garcia, K Christopher, Zhao, Yangbing, Kalos, Michael, Porter, David L, Kohli, Rahul M, Lacey, Simon F, Berger, Shelley L, Bushman, Frederic D, June, Carl H, Melenhorst, J Joseph
Published in Nature (London) (01.06.2018)
Published in Nature (London) (01.06.2018)
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Journal Article
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Ruella, Marco, Xu, Jun, Barrett, David M, Fraietta, Joseph A, Reich, Tyler J, Ambrose, David E, Klichinsky, Michael, Shestova, Olga, Patel, Prachi R, Kulikovskaya, Irina, Nazimuddin, Farzana, Bhoj, Vijay G, Orlando, Elena J, Fry, Terry J, Bitter, Hans, Maude, Shannon L, Levine, Bruce L, Nobles, Christopher L, Bushman, Frederic D, Young, Regina M, Scholler, John, Gill, Saar I, June, Carl H, Grupp, Stephan A, Lacey, Simon F, Melenhorst, J Joseph
Published in Nature medicine (01.10.2018)
Published in Nature medicine (01.10.2018)
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Journal Article
Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo
Simonetti, Francesco R, Zhang, Hao, Soroosh, Garshasb P, Duan, Jiayi, Rhodehouse, Kyle, Hill, Alison L, Beg, Subul A, McCormick, Kevin, Raymond, Hayley E, Nobles, Christopher L, Everett, John K, Kwon, Kyungyoon J, White, Jennifer A, Lai, Jun, Margolick, Joseph B, Hoh, Rebecca, Deeks, Steven G, Bushman, Frederic D, Siliciano, Janet D, Siliciano, Robert F
Published in The Journal of clinical investigation (01.02.2021)
Published in The Journal of clinical investigation (01.02.2021)
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Journal Article
CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
Nobles, Christopher L, Sherrill-Mix, Scott, Everett, John K, Reddy, Shantan, Fraietta, Joseph A, Porter, David L, Frey, Noelle, Gill, Saar I, Grupp, Stephan A, Maude, Shannon L, Siegel, Donald L, Levine, Bruce L, June, Carl H, Lacey, Simon F, Melenhorst, J Joseph, Bushman, Frederic D
Published in The Journal of clinical investigation (01.02.2020)
Published in The Journal of clinical investigation (01.02.2020)
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Journal Article
Clonal tracking in gene therapy patients reveals a diversity of human hematopoietic differentiation programs
Six, Emmanuelle, Guilloux, Agathe, Denis, Adeline, Lecoules, Arnaud, Magnani, Alessandra, Vilette, Romain, Male, Frances, Cagnard, Nicolas, Delville, Marianne, Magrin, Elisa, Caccavelli, Laure, Roudaut, Cécile, Plantier, Clemence, Sobrino, Steicy, Gregg, John, Nobles, Christopher L., Everett, John K., Hacein-Bey-Abina, Salima, Galy, Anne, Fischer, Alain, Thrasher, Adrian J., André, Isabelle, Cavazzana, Marina, Bushman, Frederic D.
Published in Blood (09.04.2020)
Published in Blood (09.04.2020)
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Journal Article
Author Correction: Decade-long leukaemia remissions with persistence of CD4 + CAR T cells
Melenhorst, J Joseph, Chen, Gregory M, Wang, Meng, Porter, David L, Chen, Changya, Collins, McKensie A, Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L, Maji, Sayantan, Frey, Noelle V, Gill, Saar I, Loren, Alison W, Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E, Davis, Megan M, Fraietta, Joseph A, Brogdon, Jennifer L, Young, Regina M, Chew, Anne, Levine, Bruce L, Siegel, Donald L, Alanio, Cécile, Wherry, E John, Bushman, Frederic D, Lacey, Simon F, Tan, Kai, June, Carl H
Published in Nature (London) (22.12.2022)
Published in Nature (London) (22.12.2022)
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Journal Article
First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma
Stadtmauer, Edward A., Cohen, Adam D., Weber, Kristy, Lacey, Simon F, Gonzalez, Vanessa E., Melenhorst, J. Joseph, Fraietta, Joseph A, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Mangan, Patricia, Gaymon, Avery, Desjardins, Stephanie, Lancaster, Eric, Salas-Mckee, January, Suhoski, Megan M., Fesnak, Andrew, O'Rourke, Matthew, Lamontagne, Anne, Siegel, Don L., Young, Regina M, Chew, Anne, Nobles, Christopher L, Bushman, Frederic D., Chang, Howard Y., Satpathy, Ansuman T., Zhao, Yangbing, Hwang, Wei-Ting, Hexner, Elizabeth O., June, Carl H
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Long-term remission despite clonal expansion of replication-competent HIV-1 isolates
Veenhuis, Rebecca T, Kwaa, Abena K, Garliss, Caroline C, Latanich, Rachel, Salgado, Maria, Pohlmeyer, Christopher W, Nobles, Christopher L, Gregg, John, Scully, Eileen P, Bailey, Justin R, Bushman, Frederic D, Blankson, Joel N
Published in JCI insight (20.09.2018)
Published in JCI insight (20.09.2018)
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Journal Article
Combining Random Gene Fission and Rational Gene Fusion To Discover Near-Infrared Fluorescent Protein Fragments That Report on Protein–Protein Interactions
Pandey, Naresh, Nobles, Christopher L, Zechiedrich, Lynn, Maresso, Anthony W, Silberg, Jonathan J
Published in ACS synthetic biology (15.05.2015)
Published in ACS synthetic biology (15.05.2015)
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Journal Article
Abstract P041: Improved sensitivity of a multi-analyte early detection test based on mutation, methylation, aneuploidy, and protein biomarkers
Gianullin, Vladimir, Hagmann, Leonardo, Arvai, Kevin, Djebbari, Amira, Nobles, Christopher L., Hogstrom, Larson, Manesse, Mael, Fa, Vuna, Zhuang, Fanglei, Chen, Xi, Katerov, Viatcheslav E., Garces, Jorge, Allawi, Hatim T., McElhinny, Abigail, Diehl, Frank, Cerqueira, Gustavo C
Published in Cancer prevention research (Philadelphia, Pa.) (01.01.2023)
Published in Cancer prevention research (Philadelphia, Pa.) (01.01.2023)
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Journal Article