Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation
Noble, Christian G, Seh, Cheah Chen, Chao, Alexander T, Shi, Pei Yong
Published in Journal of Virology (01.01.2012)
Published in Journal of Virology (01.01.2012)
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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.
Published in Nature (London) (15.06.2017)
Published in Nature (London) (15.06.2017)
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Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
Yokokawa, Fumiaki, Nilar, Shahul, Noble, Christian G, Lim, Siew Pheng, Rao, Ranga, Tania, Stefani, Wang, Gang, Lee, Gladys, Hunziker, Jürg, Karuna, Ratna, Manjunatha, Ujjini, Shi, Pei-Yong, Smith, Paul W
Published in Journal of medicinal chemistry (28.04.2016)
Published in Journal of medicinal chemistry (28.04.2016)
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Journal Article
Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor
Noble, Christian G, Lim, Siew Pheng, Chen, Yen-Liang, Liew, Chong Wai, Yap, Lijian, Lescar, Julien, Shi, Pei-Yong
Published in Journal of Virology (01.05.2013)
Published in Journal of Virology (01.05.2013)
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Journal Article
Bcl-xL and UVRAG Cause a Monomer-Dimer Switch in Beclin1
Noble, Christian G., Dong, Jing-Ming, Manser, Edward, Song, Haiwei
Published in The Journal of biological chemistry (19.09.2008)
Published in The Journal of biological chemistry (19.09.2008)
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Journal Article
Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents
Ng, Pearly Shuyi, Manjunatha, Ujjini H., Rao, Srinivasa P.S., Camacho, Luis R., Ma, Ngai Ling, Herve, Maxime, Noble, Christian G., Goh, Anne, Peukert, Stefan, Diagana, Thierry T., Smith, Paul W., Kondreddi, Ravinder Reddy
Published in European journal of medicinal chemistry (01.12.2015)
Published in European journal of medicinal chemistry (01.12.2015)
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Key features of the interaction between Pcf11 CID and RNA polymerase II CTD
Taylor, Ian A, Ramos, Andres, Noble, Christian G, Hollingworth, David, Martin, Stephen R, Ennis-Adeniran, Valerie, Smerdon, Stephen J, Kelly, Geoff
Published in Nature structural & molecular biology (01.02.2005)
Published in Nature structural & molecular biology (01.02.2005)
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Structural Basis of Mycobacterial Inhibition by Cyclomarin A
Vasudevan, Dileep, Rao, Srinivasa P.S., Noble, Christian G.
Published in The Journal of biological chemistry (25.10.2013)
Published in The Journal of biological chemistry (25.10.2013)
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Journal Article
Ten years of dengue drug discovery: Progress and prospects
Lim, Siew Pheng, Wang, Qing-Yin, Noble, Christian G., Chen, Yen-Liang, Dong, Hongping, Zou, Bin, Yokokawa, Fumiaki, Nilar, Shahul, Smith, Paul, Beer, David, Lescar, Julien, Shi, Pei-Yong
Published in Antiviral research (01.11.2013)
Published in Antiviral research (01.11.2013)
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A cocrystal structure of dengue capsid protein in complex of inhibitor
Xia, Hongjie, Xie, Xuping, Zou, Jing, Noble, Christian G., Russell, William K., Holthauzen, Luis Marcelo F., Choi, Kyung H., White, Mark A., Shi, Pei-Yong
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2020)
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Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design
Lim, Siew Pheng, Noble, Christian G, Nilar, Shahul, Shi, Pei-Yong, Yokokawa, Fumiaki
Published in Advances in experimental medicine and biology (01.01.2018)
Published in Advances in experimental medicine and biology (01.01.2018)
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Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies
Arora, Rishi, Liew, Chong Wai, Soh, Tingjin Sherryl, Otoo, Dorcas Adobea, Seh, Cheah Chen, Yue, Kimberley, Nilar, Shahul, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian G, Chen, Yen Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas M, Benson, Timothy E, Lim, Siew Pheng
Published in Journal of virology (23.11.2020)
Published in Journal of virology (23.11.2020)
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Journal Article
Strategies for development of dengue virus inhibitors
Noble, Christian G., Chen, Yen-Liang, Dong, Hongping, Gu, Feng, Lim, Siew Pheng, Schul, Wouter, Wang, Qing-Yin, Shi, Pei-Yong
Published in Antiviral research (01.03.2010)
Published in Antiviral research (01.03.2010)
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Journal Article
Direct inhibitors of InhA are active against Mycobacterium tuberculosis
Manjunatha, Ujjini H, S Rao, Srinivasa P, Kondreddi, Ravinder Reddy, Noble, Christian G, Camacho, Luis R, Tan, Bee H, Ng, Seow H, Ng, Pearly Shuyi, Ma, Ng L, Lakshminarayana, Suresh B, Herve, Maxime, Barnes, Susan W, Yu, Weixuan, Kuhen, Kelli, Blasco, Francesca, Beer, David, Walker, John R, Tonge, Peter J, Glynne, Richard, Smith, Paul W, Diagana, Thierry T
Published in Science translational medicine (07.01.2015)
Published in Science translational medicine (07.01.2015)
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NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex
Kim, Young Mee, Gayen, Shovanlal, Kang, CongBao, Joy, Joma, Huang, Qiwei, Chen, Angela Shuyi, Wee, John Liang Kuan, Ang, Melgious Jin Yan, Lim, Huichang Annie, Hung, Alvin W., Li, Rong, Noble, Christian G., Lee, Le Tian, Yip, Andy, Wang, Qing-Yin, Chia, Cheng San Brian, Hill, Jeffrey, Shi, Pei-Yong, Keller, Thomas H.
Published in The Journal of biological chemistry (03.05.2013)
Published in The Journal of biological chemistry (03.05.2013)
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