Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
Samstad, Eivind O, Niyonzima, Nathalie, Nymo, Stig, Aune, Marie H, Ryan, Liv, Bakke, Siril S, Lappegård, Knut T, Brekke, Ole-Lars, Lambris, John D, Damås, Jan K, Latz, Eicke, Mollnes, Tom E, Espevik, Terje
Published in The Journal of immunology (1950) (15.03.2014)
Published in The Journal of immunology (1950) (15.03.2014)
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Journal Article
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
Arbore, Giuseppina, West, Erin E., Rahman, Jubayer, Le Friec, Gaelle, Niyonzima, Nathalie, Pirooznia, Mehdi, Tunc, Ilker, Pavlidis, Polychronis, Powell, Nicholas, Li, Yuesheng, Liu, Poching, Servais, Aude, Couzi, Lionel, Fremeaux-Bacchi, Veronique, Placais, Leo, Ferraro, Alastair, Walsh, Patrick R., Kavanagh, David, Afzali, Behdad, Lavender, Paul, Lachmann, Helen J., Kemper, Claudia
Published in Nature communications (10.10.2018)
Published in Nature communications (10.10.2018)
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Journal Article
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
Bakke, Siril S, Aune, Marie H, Niyonzima, Nathalie, Pilely, Katrine, Ryan, Liv, Skjelland, Mona, Garred, Peter, Aukrust, Pål, Halvorsen, Bente, Latz, Eicke, Damås, Jan K, Mollnes, Tom E, Espevik, Terje
Published in The Journal of immunology (1950) (15.10.2017)
Published in The Journal of immunology (1950) (15.10.2017)
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Journal Article
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
Pilely, Katrine, Rosbjerg, Anne, Genster, Ninette, Gal, Peter, Pál, Gábor, Halvorsen, Bente, Holm, Sverre, Aukrust, Pål, Bakke, Siril Skaret, Sporsheim, Bjørnar, Nervik, Ingunn, Niyonzima, Nathalie, Bartels, Emil D, Stahl, Gregory L, Mollnes, Tom Eirik, Espevik, Terje, Garred, Peter
Published in The Journal of immunology (1950) (15.06.2016)
Published in The Journal of immunology (1950) (15.06.2016)
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Journal Article
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
Niyonzima, Nathalie, Bakke, Siril S., Gregersen, Ida, Holm, Sverre, Sandanger, Øystein, Orrem, Hilde L., Sporsheim, Bjørnar, Ryan, Liv, Kong, Xiang Yi, Dahl, Tuva Børresdatter, Skjelland, Mona, Sørensen, Kirsten Krohg, Rokstad, Anne Mari, Yndestad, Arne, Latz, Eicke, Gullestad, Lars, Andersen, Geir Ø., Damås, Jan Kristian, Aukrust, Pål, Mollnes, Tom E., Halvorsen, Bente, Espevik, Terje
Published in EBioMedicine (01.10.2020)
Published in EBioMedicine (01.10.2020)
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Journal Article
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
Niyonzima, Nathalie, Samstad, Eivind O, Aune, Marie H, Ryan, Liv, Bakke, Siril S, Rokstad, Anne Mari, Wright, Samuel D, Damås, Jan K, Mollnes, Tom E, Latz, Eicke, Espevik, Terje
Published in The Journal of immunology (1950) (01.07.2015)
Published in The Journal of immunology (1950) (01.07.2015)
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Journal Article
Complement's favourite organelle—Mitochondria?
Rahman, Jubayer, Singh, Parul, Merle, Nicolas S., Niyonzima, Nathalie, Kemper, Claudia
Published in British journal of pharmacology (01.07.2021)
Published in British journal of pharmacology (01.07.2021)
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Journal Article
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Yan, Bingyu, Freiwald, Tilo, Chauss, Daniel, Wang, Luopin, West, Erin, Mirabelli, Carmen, Zhang, Charles J, Nichols, Eva-Maria, Malik, Nazish, Gregory, Richard, Bantscheff, Marcus, Ghidelli-Disse, Sonja, Kolev, Martin, Frum, Tristan, Spence, Jason R, Sexton, Jonathan Z, Alysandratos, Konstantinos D, Kotton, Darrell N, Pittaluga, Stefania, Bibby, Jack, Niyonzima, Nathalie, Olson, Matthew R, Kordasti, Shahram, Portilla, Didier, Wobus, Christiane E, Laurence, Arian, Lionakis, Michail S, Kemper, Claudia, Afzali, Behdad, Kazemian, Majid
Published in Science Immunology (07.04.2021)
Published in Science Immunology (07.04.2021)
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T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity
Merle, Nicolas S, Freeley, Simon, Bibby, Jack, Singh, Parul, Rahman, Jubayer, Kolev, Martin, Niyonzima, Nathalie, Morgensen, Trine Hyrup, Woodruff, Trent M, Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollness, Tom Eirik, Christiansen, Mette, West, Erin E, Kemper, Claudia
Published in The Journal of immunology (1950) (01.05.2023)
Published in The Journal of immunology (1950) (01.05.2023)
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Journal Article
Cholesterol crystals use both extracellular and intracellular complement to increase NLRP3 signalling pathways in atherosclerosis
Espevik, Terje, Niyonzima, Nathalie, Bakke, Siril Skaret, West, Erin, Rahman, Jubayer, Aukrust, Pål, Kemper, Claudia, Mollnes, Tom Eirik, Halvorsen, Bente
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Journal Article
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
Nymo, Stig, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik
Published in Immunobiology (1979) (01.10.2014)
Published in Immunobiology (1979) (01.10.2014)
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Journal Article
T cell-intrinsic C5L2 activation protects against uncontrolled inflammatory Th responses and autoimmunity
West, Erin E, Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Mogensen, Trine Hyrup, Woodruff, Trent M, Monk, Peter, Lappegard, Knut, Espevik, Terje, Mollnes, Tom Eirik, Christiansen, Mette, Kemper, Claudia
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Journal Article
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Yan, Bingyu, Freiwald, Tilo, Chauss, Daniel, Wang, Luopin, West, Erin, Mirabelli, Carmen, Zhang, Charles J., Nichols, Eva-Maria, Malik, Nazish, Gregory, Richard, Bantscheff, Marcus, Ghidelli-Disse, Sonja, Kolev, Martin, Frum, Tristan, Spence, Jason R., Sexton, Jonathan Z., Alysandratos, Konstantinos D., Kotton, Darrell N., Pittaluga, Stefania, Bibby, Jack, Niyonzima, Nathalie, Olson, Matthew R., Kordasti, Shahram, Portilla, Didier, Wobus, Christiane E., Laurence, Arian, Lionakis, Michail S., Kemper, Claudia, Afzali, Behdad, Kazemian, Majid
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Journal Article
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
Niyonzima, Nathalie, Rahman, Jubayer, Kunz, Natalia, West, Erin E, Freiwald, Tilo, Desai, Jigar V, Merle, Nicolas S, Gidon, Alexandre, Sporsheim, Bjørnar, Lionakis, Michail S, Evensen, Kristin, Lindberg, Beate, Skagen, Karolina, Skjelland, Mona, Singh, Parul, Haug, Markus, Ruseva, Marieta M, Kolev, Martin, Bibby, Jack, Marshall, Olivia, O'Brien, Brett, Deeks, Nigel, Afzali, Behdad, Clark, Richard J, Woodruff, Trent M, Pryor, Milton, Yang, Zhi-Hong, Remaley, Alan T, Mollnes, Tom E, Hewitt, Stephen M, Yan, Bingyu, Kazemian, Majid, Kiss, Máté G, Binder, Christoph J, Halvorsen, Bente, Espevik, Terje, Kemper, Claudia
Published in Science immunology (24.12.2021)
Published in Science immunology (24.12.2021)
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Journal Article
The intracellular C5 system is critical to DAMP sensing and cellular responses in human monocytes
Niyonzima, Nathalie, Freeley, Simon, Arbore, Giuseppina, Le Friec, Gaelle, Lappegård, Knut Tore, Mollnes, Tom Eirik, Kemper, Claudia, Espevik, Terje
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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Journal Article
The intracellular C5 system is critical to DAMP sensing and cellular responses in human monocytes
Niyonzima, Nathalie, Freeley, Simon, Arbore, Giuseppina, Le Friec, Gaelle, Lappegård, Knut Tore, Mollnes, Tom Eirik, Kemper, Claudia, Espevik, Terje
Published in Molecular immunology (01.09.2017)
Published in Molecular immunology (01.09.2017)
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Journal Article
Complement receptor CD46 is a key co-stimulator for optimal human CD8+ T cell effector function
Arbore, Giuseppina, Le Friec, Gaelle, West, Erin E., Niyonzima, Nathalie, Rahman, Jubayer, Pavlidis, Polychronis, Powell, Nicholas, Afzali, Behdad, Lavender, Paul, Lachmann, Helen J., Kemper, Claudia
Published in Molecular immunology (01.10.2018)
Published in Molecular immunology (01.10.2018)
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Journal Article
Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation
West, Erin E., Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Peter N., Kemper, Claudia
Published in Molecular immunology (01.10.2018)
Published in Molecular immunology (01.10.2018)
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Journal Article
Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg
West, Erin E., Freeley, Simon, Le Friec, Gaelle, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Pete, Kemper, Claudia
Published in Molecular immunology (01.09.2017)
Published in Molecular immunology (01.09.2017)
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Journal Article