Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Clare, Rachel H, Bardelle, Catherine, Harper, Paul, Hong, W David, Börjesson, Ulf, Johnston, Kelly L, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A N, Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L, Slatko, Barton E, Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G, O'Neill, Paul M, Taylor, Mark J, Ward, Stephen A
Published in Nature communications (02.01.2019)
Published in Nature communications (02.01.2019)
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Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
Biagini, Giancarlo A, Fisher, Nicholas, Shone, Alison E, Mubaraki, Murad A, Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A, Nixon, Gemma L, Chadwick, James, Hemingway, Janet, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H. M, Berry, Neil G, O’Neill, Paul M, Ward, Stephen A
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (22.05.2012)
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Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
O'Neill, Paul M, Amewu, Richard K, Nixon, Gemma L, Bousejra ElGarah, Fatima, Mungthin, Mathirut, Chadwick, James, Shone, Alison E, Vivas, Livia, Lander, Hollie, Barton, Victoria, Muangnoicharoen, Sant, Bray, Patrick G, Davies, Jill, Park, B. Kevin, Wittlin, Sergio, Brun, Reto, Preschel, Michael, Zhang, Kesheng, Ward, Stephen A
Published in Angewandte Chemie (International ed.) (02.08.2010)
Published in Angewandte Chemie (International ed.) (02.08.2010)
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Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Pidathala, Chandrakala, Amewu, Richard, Pacorel, Bénédicte, Nixon, Gemma L, Gibbons, Peter, Hong, W. David, Leung, Suet C, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease
Nixon, Gemma L, McEntee, Laura, Johnson, Adam, Farrington, Nicola, Whalley, Sarah, Livermore, Joanne, Natal, Cristien, Washbourn, Gina, Bibby, Jaclyn, Berry, Neil, Lestner, Jodi, Truong, Megan, Owen, Andrew, Lalloo, David, Charles, Ian, Hope, William
Published in Antimicrobial agents and chemotherapy (01.04.2018)
Published in Antimicrobial agents and chemotherapy (01.04.2018)
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Journal Article
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action
Fernández-Álvaro, Elena, Hong, W David, Nixon, Gemma L, O'Neill, Paul M, Calderón, Félix
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Journal Article
Antimalarial pharmacology and therapeutics of atovaquone
Nixon, Gemma L, Moss, Darren M, Shone, Alison E, Lalloo, David G, Fisher, Nicholas, O'Neill, Paul M, Ward, Stephen A, Biagini, Giancarlo A
Published in Journal of antimicrobial chemotherapy (01.05.2013)
Published in Journal of antimicrobial chemotherapy (01.05.2013)
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Journal Article
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2019)
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Journal Article
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis
Hong, W. David, Gibbons, Peter D, Leung, Suet C, Amewu, Richard, Stocks, Paul A, Stachulski, Andrew, Horta, Pedro, Cristiano, Maria L. S, Shone, Alison E, Moss, Darren, Ardrey, Alison, Sharma, Raman, Warman, Ashley J, Bedingfield, Paul T. P, Fisher, Nicholas E, Aljayyoussi, Ghaith, Mead, Sally, Caws, Maxine, Berry, Neil G, Ward, Stephen A, Biagini, Giancarlo A, O’Neill, Paul M, Nixon, Gemma L
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
Stachulski, Andrew V, Taujanskas, Joshua, Pate, Sophie L, Rajoli, Rajith K. R, Aljayyoussi, Ghaith, Pennington, Shaun H, Ward, Stephen A, Hong, Weiqian David, Biagini, Giancarlo A, Owen, Andrew, Nixon, Gemma L, Leung, Suet C, O’Neill, Paul M
Published in ACS infectious diseases (11.06.2021)
Published in ACS infectious diseases (11.06.2021)
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Journal Article
Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials
O' Neill, Paul M., Sabbani, Sunil, Nixon, Gemma L., Schnaderbeck, Matthew, Roberts, Natalie L., Shore, Emma R., Riley, Christopher, Murphy, Ben, McGillan, Paul, Ward, Stephen A., Davies, Jill, Amewu, Richard K.
Published in Tetrahedron (06.10.2016)
Published in Tetrahedron (06.10.2016)
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Journal Article
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205
Woodley, Christopher M, Nixon, Gemma L, Basilico, Nicoletta, Parapini, Silvia, Hong, Weiqian David, Ward, Stephen A, Biagini, Giancarlo A, Leung, Suet C, Taramelli, Donatella, Onuma, Keiko, Hasebe, Takashi, O’Neill, Paul M
Published in ACS medicinal chemistry letters (08.07.2021)
Published in ACS medicinal chemistry letters (08.07.2021)
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Journal Article
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in Plasmodium falciparum
Lisauskaitė, Monika, Nixon, Gemma L, Woodley, Christopher M, Berry, Neil G, Coninckx, Andy, Qie, L Charlie, Leung, Suet C, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia, Ward, Stephen A, Vadas, Oscar, Soldati-Favre, Dominique, Hong, W David, O'Neill, Paul M
Published in RSC chemical biology (03.01.2024)
Published in RSC chemical biology (03.01.2024)
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Journal Article
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
O' Neill, Paul M., Stocks, Paul A., Sabbani, Sunil, Roberts, Natalie L., Amewu, Richard K., Shore, Emma R., Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Jiménez-Díaz, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A., Ryan, Eileen, Chen, Gong, Shackleford, David M., Davies, Jill, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Published in Bioorganic & medicinal chemistry (15.07.2018)
Published in Bioorganic & medicinal chemistry (15.07.2018)
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Journal Article
Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era
Nixon, Gemma L, Pidathala, Chandrakala, Shone, Alison E, Antoine, Thomas, Fisher, Nicholas, O'Neill, Paul M, Ward, Stephen A, Biagini, Giancarlo A
Published in Future medicinal chemistry (01.09.2013)
Published in Future medicinal chemistry (01.09.2013)
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Journal Article
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action: Miniperspective
Fernández-Álvaro, Elena, Hong, W. David, Nixon, Gemma L, O’Neill, Paul M, Calderón, Félix
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Journal Article
Identification of 2‑Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis
Jeffreys, Laura N., Ardrey, Alison, Hafiz, Taghreed A., Dyer, Lauri-Anne, Warman, Ashley J., Mosallam, Nada, Nixon, Gemma L., Fisher, Nicholas E., Hong, W. David, Leung, Suet C., Aljayyoussi, Ghaith, Bibby, Jaclyn, Almeida, Deepak V., Converse, Paul J., Fotouhi, Nader, Berry, Neil G., Nuermberger, Eric L., Upton, Anna M., O’Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Published in ACS infectious diseases (10.02.2023)
Published in ACS infectious diseases (10.02.2023)
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Journal Article
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2)
Leung, Suet C, Gibbons, Peter, Amewu, Richard, Nixon, Gemma L, Pidathala, Chandrakala, Hong, W. David, Pacorel, Bénédicte, Berry, Neil G, Sharma, Raman, Stocks, Paul A, Srivastava, Abhishek, Shone, Alison E, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas E, Warman, Ashley J, Biagini, Giancarlo A, Ward, Stephen A, O’Neill, Paul M
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Journal Article
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis
McGillan, Paul, Berry, Neil G, Nixon, Gemma L, Leung, Suet C, Webborn, Peter J. H, Wenlock, Mark C, Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H, Cook, Darren A, Johnston, Kelly L, Ford, Louise, Ward, Stephen A, Taylor, Mark J, Hong, W. David, O’Neill, Paul M
Published in ACS medicinal chemistry letters (09.09.2021)
Published in ACS medicinal chemistry letters (09.09.2021)
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Journal Article
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials
McConville, Matthew, Fernández, Jorge, Angulo-Barturen, Íñigo, Bahamontes-Rosa, Noemi, Ballell-Pages, Lluis, Castañeda, Pablo, de Cózar, Cristina, Crespo, Benigno, Guijarro, Laura, Jiménez-Díaz, María Belén, Martínez-Martínez, Maria S, de Mercado, Jaime, Santos-Villarejo, Ángel, Sanz, Laura M, Frigerio, Micol, Washbourn, Gina, Ward, Stephen A, Nixon, Gemma L, Biagini, Giancarlo A, Berry, Neil G, Blackman, Michael J, Calderón, Félix, O’Neill, Paul M
Published in Journal of medicinal chemistry (27.08.2015)
Published in Journal of medicinal chemistry (27.08.2015)
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