Metabotropic glutamate receptors: physiology, pharmacology, and disease
Niswender, Colleen M, Conn, P Jeffrey
Published in Annual review of pharmacology and toxicology (01.01.2010)
Published in Annual review of pharmacology and toxicology (01.01.2010)
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Journal Article
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
Wu, Huixian, Wang, Chong, Gregory, Karen J., Han, Gye Won, Cho, Hyekyung P., Xia, Yan, Niswender, Colleen M., Katritch, Vsevolod, Meiler, Jens, Cherezov, Vadim, Conn, P. Jeffrey, Stevens, Raymond C.
Published in Science (American Association for the Advancement of Science) (04.04.2014)
Published in Science (American Association for the Advancement of Science) (04.04.2014)
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Journal Article
A Coordinated Attack: Rett Syndrome Therapeutic Development
Gogliotti, Rocco G., Niswender, Colleen M.
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2019)
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2019)
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Journal Article
Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery
Melancon, Bruce J, Hopkins, Corey R, Wood, Michael R, Emmitte, Kyle A, Niswender, Colleen M, Christopoulos, Arthur, Conn, P. Jeffrey, Lindsley, Craig W
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Journal Article
Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release
Foster, Daniel J., Wilson, Jermaine M., Remke, Daniel H., Mahmood, M. Suhaib, Uddin, M. Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J., Niswender, Colleen M., Jones, Carrie K., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey
Published in Neuron (Cambridge, Mass.) (21.09.2016)
Published in Neuron (Cambridge, Mass.) (21.09.2016)
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Journal Article
Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction
Walker, Adam G., Wenthur, Cody J., Xiang, Zixiu, Rook, Jerri M., Emmitte, Kyle A., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2015)
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Journal Article
Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target
Gogliotti, Rocco G, Fisher, Nicole M, Stansley, Branden J, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey, Niswender, Colleen M
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
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Journal Article
mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
Maksymetz, James, Byun, Nellie E., Luessen, Deborah J., Li, Brianna, Barry, Robert L., Gore, John C., Niswender, Colleen M., Lindsley, Craig W., Joffe, Max E., Conn, P. Jeffrey
Published in Cell reports (Cambridge) (02.11.2021)
Published in Cell reports (Cambridge) (02.11.2021)
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Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders
Fisher, Nicole M., Gould, Robert W., Gogliotti, Rocco G., McDonald, Annalise J., Badivuku, Hana, Chennareddy, Susmita, Buch, Aditi B., Moore, Annah M., Jenkins, Matthew T., Robb, W. Hudson, Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey, Niswender, Colleen M.
Published in Genes, brain and behavior (01.09.2020)
Published in Genes, brain and behavior (01.09.2020)
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Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
Iderberg, Hanna, Maslava, Natallia, Thompson, Analisa D., Bubser, Michael, Niswender, Colleen M., Hopkins, Corey R., Lindsley, Craig W., Conn, P. Jeffrey, Jones, Carrie K., Cenci, M. Angela
Published in Neuropharmacology (01.08.2015)
Published in Neuropharmacology (01.08.2015)
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Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6‑((1H‑Pyrazolo[4,3‑b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)
Bollinger, Sean R, Engers, Darren W, Panarese, Joseph D, West, Mary, Engers, Julie L, Loch, Matthew T, Rodriguez, Alice L, Blobaum, Anna L, Jones, Carrie K, Thompson Gray, Analisa, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R
Published in Journal of medicinal chemistry (10.01.2019)
Published in Journal of medicinal chemistry (10.01.2019)
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Journal Article
ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice
Kaufmann, Kristian, Romaine, Ian, Days, Emily, Pascual, Conrado, Malik, Adam, Yang, Liya, Zou, Bende, Du, Yu, Sliwoski, Greg, Morrison, Ryan D, Denton, Jerod, Niswender, Colleen M, Daniels, J. Scott, Sulikowski, Gary A, Xie, Xinmin (Simon), Lindsley, Craig W, Weaver, C. David
Published in ACS chemical neuroscience (18.09.2013)
Published in ACS chemical neuroscience (18.09.2013)
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Journal Article
Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice
Pancani, Tristano, Foster, Daniel J., Moehle, Mark S., Bichell, Terry Jo, Bradley, Emma, Bridges, Thomas M., Klar, Rebecca, Poslusney, Mike, Rook, Jerri M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Wood, Michael R., Bowman, Aaron B., Lindsley, Craig W., Xiang, Zixiu, Conn, P. Jeffrey
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.2015)
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Journal Article
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
Bubser, Michael, Bridges, Thomas M, Dencker, Ditte, Gould, Robert W, Grannan, Michael, Noetzel, Meredith J, Lamsal, Atin, Niswender, Colleen M, Daniels, J. Scott, Poslusney, Michael S, Melancon, Bruce J, Tarr, James C, Byers, Frank W, Wess, Jürgen, Duggan, Mark E, Dunlop, John, Wood, Michael W, Brandon, Nicholas J, Wood, Michael R, Lindsley, Craig W, Conn, P. Jeffrey, Jones, Carrie K
Published in ACS chemical neuroscience (15.10.2014)
Published in ACS chemical neuroscience (15.10.2014)
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Journal Article
Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4
Niswender, Colleen M, Johnson, Kari A, Weaver, C David, Jones, Carrie K, Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L, Marlo, Joy E, de Paulis, Tomas, Thompson, Analisa D, Days, Emily L, Nalywajko, Tasha, Austin, Cheryl A, Williams, Michael Baxter, Ayala, Jennifer E, Williams, Richard, Lindsley, Craig W, Conn, P Jeffrey
Published in Molecular pharmacology (01.11.2008)
Published in Molecular pharmacology (01.11.2008)
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Journal Article
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
Shirey, Jana K, Xiang, Zixiu, Orton, Darren, Brady, Ashley E, Johnson, Kari A, Williams, Richard, Ayala, Jennifer E, Rodriguez, Alice L, Wess, Jürgen, Weaver, David, Niswender, Colleen M, Conn, P Jeffrey
Published in Nature chemical biology (2008)
Published in Nature chemical biology (2008)
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Journal Article
Challenges in the development of an M-4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Wood, Michael R., Noetzel, Meredith J., Poslusney, Michael S., Melancon, Bruce J., Tarr, James C., Lamsal, Atin, Chang, Sichen, Luscombe, Vincent B., Weiner, Rebecca L., Cho, Hyekyung P., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
Published in Bioorganic & medicinal chemistry letters (15.01.2017)
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Journal Article
Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2
Felts, Andrew S, Rodriguez, Alice L, Smith, Katrina A, Engers, Julie L, Morrison, Ryan D, Byers, Frank W, Blobaum, Anna L, Locuson, Charles W, Chang, Sichen, Venable, Daryl F, Niswender, Colleen M, Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W, Emmitte, Kyle A
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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