Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers
Mukhopadhyay, Suman, Goswami, Debanjan, Adiseshaiah, Pavan P, Burgan, William, Yi, Ming, Guerin, Theresa M, Kozlov, Serguei V, Nissley, Dwight V, McCormick, Frank
Published in Cancer research (Chicago, Ill.) (15.04.2020)
Published in Cancer research (Chicago, Ill.) (15.04.2020)
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Journal Article
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
Tran, Timothy H., Chan, Albert H., Young, Lucy C., Bindu, Lakshman, Neale, Chris, Messing, Simon, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Denson, John-Paul, Esposito, Dominic, Nissley, Dwight V., Stephen, Andrew G., McCormick, Frank, Simanshu, Dhirendra K.
Published in Nature communications (19.02.2021)
Published in Nature communications (19.02.2021)
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Journal Article
Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics
Chao, Fa-An, Dharmaiah, Srisathiyanarayanan, Taylor, Troy, Messing, Simon, Gillette, William, Esposito, Dominic, Nissley, Dwight V, McCormick, Frank, Byrd, R. Andrew, Simanshu, Dhirendra K, Cornilescu, Gabriel
Published in Journal of the American Chemical Society (09.03.2022)
Published in Journal of the American Chemical Society (09.03.2022)
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Journal Article
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner
Agamasu, Constance, Ghirlando, Rodolfo, Taylor, Troy, Messing, Simon, Tran, Timothy H., Bindu, Lakshman, Tonelli, Marco, Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G.
Published in Biophysical journal (19.03.2019)
Published in Biophysical journal (19.03.2019)
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Journal Article
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
Lai, Lick Pui, Fer, Nicole, Burgan, William, Wall, Vanessa E, Xu, Bingfang, Soppet, Daniel, Esposito, Dominic, Nissley, Dwight V, McCormick, Frank
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (01.02.2022)
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Journal Article
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome
Bonsor, Daniel A., Alexander, Patrick, Snead, Kelly, Hartig, Nicole, Drew, Matthew, Messing, Simon, Finci, Lorenzo I., Nissley, Dwight V., McCormick, Frank, Esposito, Dominic, Rodriguez-Viciana, Pablo, Stephen, Andrew G., Simanshu, Dhirendra K.
Published in Nature structural & molecular biology (01.10.2022)
Published in Nature structural & molecular biology (01.10.2022)
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Journal Article
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR
Yan, Wupeng, Markegard, Evan, Dharmaiah, Srisathiyanarayanan, Urisman, Anatoly, Drew, Matthew, Esposito, Dominic, Scheffzek, Klaus, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K.
Published in Cell reports (Cambridge) (21.07.2020)
Published in Cell reports (Cambridge) (21.07.2020)
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Journal Article
The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations
Yi, Ming, Soppet, Daniel, McCormick, Frank, Nissley, Dwight V.
Published in Scientific reports (26.10.2024)
Published in Scientific reports (26.10.2024)
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Journal Article
Progress in Targeting KRAS Directly
Nissley, Dwight V, Stephen, Andrew G, Yi, Ming, McCormick, Frank
Published in Methods in molecular biology (Clifton, N.J.) (2024)
Published in Methods in molecular biology (Clifton, N.J.) (2024)
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Journal Article
Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
Sherekar, Mukul, Han, Sae-Won, Ghirlando, Rodolfo, Messing, Simon, Drew, Matthew, Rabara, Dana, Waybright, Timothy, Juneja, Puneet, O'Neill, Hugh, Stanley, Christopher B., Bhowmik, Debsindhu, Ramanathan, Arvind, Subramaniam, Sriram, Nissley, Dwight V., Gillette, William, McCormick, Frank, Esposito, Dominic
Published in The Journal of biological chemistry (24.01.2020)
Published in The Journal of biological chemistry (24.01.2020)
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Journal Article
The confluence of machine learning and multiscale simulations
Bhatia, Harsh, Aydin, Fikret, Carpenter, Timothy S., Lightstone, Felice C., Bremer, Peer-Timo, Ingólfsson, Helgi I., Nissley, Dwight V., Streitz, Frederick H.
Published in Current opinion in structural biology (01.06.2023)
Published in Current opinion in structural biology (01.06.2023)
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Journal Article
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane
Van, Que N., López, Cesar A., Tonelli, Marco, Taylor, Troy, Niu, Ben, Stanley, Christopher B., Bhowmik, Debsindhu, Tran, Timothy H., Frank, Peter H., Messing, Simon, Alexander, Patrick, Scott, Daniel, Ye, Xiaoying, Drew, Matt, Chertov, Oleg, Lösche, Mathias, Ramanathan, Arvind, Gross, Michael L., Hengartner, Nicolas W., Westler, William M., Markley, John L., Simanshu, Dhirendra K., Nissley, Dwight V., Gillette, William K., Esposito, Dominic, McCormick, Frank, Gnanakaran, S., Heinrich, Frank, Stephen, Andrew G.
Published in Proceedings of the National Academy of Sciences - PNAS (29.09.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (29.09.2020)
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Journal Article
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEd
Dharmaiah, Srisathiyanarayanan, Bindu, Lakshman, Tran, Timothy H, Gillette, William K, Frank, Peter H, Ghirlando, Rodolfo, Nissley, Dwight V, Esposito, Dominic, McCormick, Frank, Stephen, Andrew G, Simanshu, Dhirendra K
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
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Journal Article
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ
Dharmaiah, Srisathiyanarayanan, Bindu, Lakshman, Tran, Timothy H., Gillette, William K., Frank, Peter H., Ghirlando, Rodolfo, Nissley, Dwight V., Esposito, Dominic, McCormick, Frank, Stephen, Andrew G., Simanshu, Dhirendra K.
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
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Journal Article
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
Lakshman, Bindu, Messing, Simon, Schmid, Eva M., Clogston, Jeffrey D., Gillette, William K., Esposito, Dominic, Kessing, Bailey, Fletcher, Daniel A., Nissley, Dwight V., McCormick, Frank, Stephen, Andrew G., Jean-Francois, Frantz L.
Published in The Journal of biological chemistry (08.02.2019)
Published in The Journal of biological chemistry (08.02.2019)
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Journal Article
Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells
Desir, Snider, Wong, Phillip, Turbyville, Thomas, Chen, De, Shetty, Mihir, Clark, Christopher, Zhai, Edward, Romin, Yevgeniy, Manova-Todorova, Katia, Starr, Timothy K, Nissley, Dwight V, Steer, Clifford J, Subramanian, Subbaya, Lou, Emil
Published in Cancers (26.06.2019)
Published in Cancers (26.06.2019)
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Journal Article
Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior
Goswami, Debanjan, Chen, De, Yang, Yue, Gudla, Prabhakar R, Columbus, John, Worthy, Karen, Rigby, Megan, Wheeler, Madeline, Mukhopadhyay, Suman, Powell, Katie, Burgan, William, Wall, Vanessa, Esposito, Dominic, Simanshu, Dhirendra K, Lightstone, Felice C, Nissley, Dwight V, McCormick, Frank, Turbyville, Thomas
Published in eLife (20.01.2020)
Published in eLife (20.01.2020)
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