Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
Husted, Anna Sofie, Ekberg, Jeppe H., Tripp, Emma, Nissen, Tinne A.D., Meijnikman, Stijn, O'Brien, Shannon L., Ulven, Trond, Acherman, Yair, Bruin, Sjoerd C., Nieuwdorp, Max, Gerhart-Hines, Zach, Calebiro, Davide, Dragsted, Lars O., Schwartz, Thue W.
Published in Molecular metabolism (Germany) (01.12.2020)
Published in Molecular metabolism (Germany) (01.12.2020)
Get full text
Journal Article
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Lückmann, Michael, Trauelsen, Mette, Bentsen, Marie A., Nissen, Tinne A. D., Martins, Joao, Fallah, Zohreh, Nygaard, Mads M., Papaleo, Elena, Lindorff-Larsen, Kresten, Schwartz, Thue W., Frimurer, Thomas M.
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2019)
Get full text
Journal Article
Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
Lückmann, Michael, Shenol, Aslihan, Nissen, Tinne A. D., Petersen, Jacob E., Kouvchinov, David, Schwartz, Thue W., Frimurer, Thomas M.
Published in ACS medicinal chemistry letters (08.12.2022)
Published in ACS medicinal chemistry letters (08.12.2022)
Get full text
Journal Article