Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling
Kamimura, Hidetaka, Ito, Satoshi, Chijiwa, Hiroyuki, Okuzono, Takeshi, Ishiguro, Tomohiro, Yamamoto, Yosuke, Nishinoaki, Sho, Ninomiya, Shin-Ichi, Mitsui, Marina, Kalgutkar, Amit S., Yamazaki, Hiroshi, Suemizu, Hiroshi
Published in Xenobiotica (04.05.2017)
Published in Xenobiotica (04.05.2017)
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Journal Article
Elucidation of parmacokinetics of PF-04937319, a partial glucokinase activator, and its disproportionate n-demethylated metabolite in chimeric mice with humanized livers
Ito, Satoshi, Chijiwa, Hiroyuki, Okuzono, Takeshi, Ishiguro, Tomohiro, Yamamoto, Yosuke, Nishinoaki, Sho, Kuronuma, Miyuki, Suemizu, Hiroshi, Kalgutkar, Amit S., Kamimura, Hidetaka, Ninomiya, Shin-ichi, Yamazaki, Hiroshi
Published in Drug metabolism and pharmacokinetics (01.01.2017)
Published in Drug metabolism and pharmacokinetics (01.01.2017)
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Journal Article