A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands
Matsukawa, Jun, Hori, Yasunobu, Nishida, Haruyuki, Kajino, Masahiro, Inatomi, Nobuhiro
Published in Biochemical pharmacology (01.05.2011)
Published in Biochemical pharmacology (01.05.2011)
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1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases
Hori, Yasunobu, Imanishi, Akio, Matsukawa, Jun, Tsukimi, Yasuhiro, Nishida, Haruyuki, Arikawa, Yasuyoshi, Hirase, Keizo, Kajino, Masahiro, Inatomi, Nobuhiro
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
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Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)
Arikawa, Yasuyoshi, Nishida, Haruyuki, Kurasawa, Osamu, Hasuoka, Atsushi, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Matsukawa, Jun, Imanishi, Akio, Kondo, Mitsuyo, Tarui, Naoki, Hamada, Teruki, Takagi, Terufumi, Takeuchi, Toshiyuki, Kajino, Masahiro
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438)
Otake, Kazuyoshi, Sakurai, Yuuichi, Nishida, Haruyuki, Fukui, Hideo, Tagawa, Yoshihiko, Yamasaki, Hitomi, Karashima, Masatoshi, Otsuka, Keiichi, Inatomi, Nobuhiro
Published in Advances in therapy (01.07.2016)
Published in Advances in therapy (01.07.2016)
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Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers
Nishida, Haruyuki, Hasuoka, Atsushi, Arikawa, Yasuyoshi, Kurasawa, Osamu, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Sato, Fumihiko, Tarui, Naoki, Imanishi, Akio, Kondo, Mitsuyo, Takagi, Terufumi, Kajino, Masahiro
Published in Bioorganic & medicinal chemistry (15.06.2012)
Published in Bioorganic & medicinal chemistry (15.06.2012)
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Journal Article
Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs)
Arikawa, Yasuyoshi, Hasuoka, Atsushi, Nishida, Haruyuki, Hirase, Keizo, Inatomi, Nobuhiro, Takagi, Terufumi, Tarui, Naoki, Kawamoto, Makiko, Imanishi, Akio, Itoh, Fumio, Kajino, Masahiro
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
Published in Bioorganic & medicinal chemistry letters (15.05.2015)
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A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals
Hori, Yasunobu, Matsukawa, Jun, Takeuchi, Toshiyuki, Nishida, Haruyuki, Kajino, Masahiro, Inatomi, Nobuhiro
Published in The Journal of pharmacology and experimental therapeutics (01.06.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2011)
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Journal Article
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers
Imaeda, Toshihiro, Ono, Koji, Nakai, Kazuo, Hori, Yasunobu, Matsukawa, Jun, Takagi, Terufumi, Fujioka, Yasushi, Tarui, Naoki, Kondo, Mitsuyo, Imanishi, Akio, Inatomi, Nobuhiro, Kajino, Masahiro, Itoh, Fumio, Nishida, Haruyuki
Published in Bioorganic & medicinal chemistry (15.07.2017)
Published in Bioorganic & medicinal chemistry (15.07.2017)
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Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion
Nishida, Haruyuki, Fujimori, Ikuo, Arikawa, Yasuyoshi, Hirase, Keizo, Ono, Koji, Nakai, Kazuo, Inatomi, Nobuhiro, Hori, Yasunobu, Matsukawa, Jun, Fujioka, Yasushi, Imanishi, Akio, Fukui, Hideo, Itoh, Fumio
Published in Bioorganic & medicinal chemistry (01.07.2017)
Published in Bioorganic & medicinal chemistry (01.07.2017)
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Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action
Nishida, Haruyuki, Arikawa, Yasuyoshi, Hirase, Keizo, Imaeda, Toshihiro, Inatomi, Nobuhiro, Hori, Yasunobu, Matsukawa, Jun, Fujioka, Yasushi, Hamada, Teruki, Iida, Motoo, Nishitani, Mitsuyoshi, Imanishi, Akio, Fukui, Hideo, Itoh, Fumio, Kajino, Masahiro
Published in Bioorganic & medicinal chemistry (01.07.2017)
Published in Bioorganic & medicinal chemistry (01.07.2017)
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Journal Article
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1 H -spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers
Imaeda, Toshihiro, Ono, Koji, Nakai, Kazuo, Hori, Yasunobu, Matsukawa, Jun, Takagi, Terufumi, Fujioka, Yasushi, Tarui, Naoki, Kondo, Mitsuyo, Imanishi, Akio, Inatomi, Nobuhiro, Kajino, Masahiro, Itoh, Fumio, Nishida, Haruyuki
Published in Bioorganic & medicinal chemistry (01.07.2017)
Published in Bioorganic & medicinal chemistry (01.07.2017)
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Journal Article
A Study Comparing the Antisecretory Effect of TAK-438, a Novel Potassium-Competitive Acid Blocker (P-CAB) With Lansoprazole in Animals
Hori, Yasunobu, Matsukawa, Jun, Takeuchi, Toshiyuki, Nishida, Haruyuki, Kajino, Masahiro, Inatomi, Nobuhiro
Published in Gastroenterology (New York, N.Y. 1943) (2011)
Published in Gastroenterology (New York, N.Y. 1943) (2011)
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