Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
Diering, Graham H., Nirujogi, Raja S., Roth, Richard H., Worley, Paul F., Pandey, Akhilesh, Huganir, Richard L.
Published in Science (American Association for the Advancement of Science) (03.02.2017)
Published in Science (American Association for the Advancement of Science) (03.02.2017)
Get full text
Journal Article
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Steger, Martin, Diez, Federico, Dhekne, Herschel S, Lis, Pawel, Nirujogi, Raja S, Karayel, Ozge, Tonelli, Francesca, Martinez, Terina N, Lorentzen, Esben, Pfeffer, Suzanne R, Alessi, Dario R, Mann, Matthias
Published in eLife (10.11.2017)
Published in eLife (10.11.2017)
Get full text
Journal Article
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
Nirujogi, Raja S, Tonelli, Francesca, Taylor, Matthew, Lis, Pawel, Zimprich, Alexander, Sammler, Esther, Alessi, Dario R
Published in Biochemical journal (29.01.2021)
Published in Biochemical journal (29.01.2021)
Get more information
Journal Article
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Berndsen, Kerryn, Lis, Pawel, Yeshaw, Wondwossen M, Wawro, Paulina S, Nirujogi, Raja S, Wightman, Melanie, Macartney, Thomas, Dorward, Mark, Knebel, Axel, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R
Published in eLife (30.10.2019)
Published in eLife (30.10.2019)
Get full text
Journal Article
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, Asad U, Karapetsas, Athanasios, Nirujogi, Raja S, Mathea, Sebastian, Chatterjee, Deep, Pal, Prosenjit, Lis, Pawel, Taylor, Matthew, Purlyte, Elena, Gourlay, Robert, Dorward, Mark, Weidlich, Simone, Toth, Rachel, Polinski, Nicole K, Knapp, Stefan, Tonelli, Francesca, Alessi, Dario R
Published in Biochemical journal (12.02.2021)
Published in Biochemical journal (12.02.2021)
Get more information
Journal Article
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Malik, Asad U, Karapetsas, Athanasios, Nirujogi, Raja S, Chatterjee, Deep, Phung, Toan K, Wightman, Melanie, Gourlay, Robert, Morrice, Nick, Mathea, Sebastian, Knapp, Stefan, Alessi, Dario R
Published in Biochemical journal (30.09.2022)
Published in Biochemical journal (30.09.2022)
Get more information
Journal Article
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Virdi, Gurvir S., Choi, Minee L., Evans, James R., Yao, Zhi, Athauda, Dilan, Strohbuecker, Stephanie, Nirujogi, Raja S., Wernick, Anna I., Pelegrina-Hidalgo, Noelia, Leighton, Craig, Saleeb, Rebecca S., Kopach, Olga, Alrashidi, Haya, Melandri, Daniela, Perez-Lloret, Jimena, Angelova, Plamena R., Sylantyev, Sergiy, Eaton, Simon, Heales, Simon, Rusakov, Dmitri A., Alessi, Dario R., Kunath, Tilo, Horrocks, Mathew H., Abramov, Andrey Y., Patani, Rickie, Gandhi, Sonia
Published in NPJ Parkinson's Disease (24.11.2022)
Published in NPJ Parkinson's Disease (24.11.2022)
Get full text
Journal Article
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2
Liu, Xingui, Kalogeropulou, Alexia F., Domingos, Sofia, Makukhin, Nikolai, Nirujogi, Raja S., Singh, Francois, Shpiro, Natalia, Saalfrank, Anton, Sammler, Esther, Ganley, Ian G., Moreira, Rui, Alessi, Dario R., Ciulli, Alessio
Published in Journal of the American Chemical Society (21.09.2022)
Published in Journal of the American Chemical Society (21.09.2022)
Get full text
Journal Article
Golgi-IP, a tool for multimodal analysis of Golgi molecular content
Fasimoye, Rotimi, Dong, Wentao, Nirujogi, Raja S, Rawat, Eshaan S, Iguchi, Miharu, Nyame, Kwamina, Phung, Toan K, Bagnoli, Enrico, Prescott, Alan R, Alessi, Dario R, Abu-Remaileh, Monther
Published in Proceedings of the National Academy of Sciences - PNAS (16.05.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (16.05.2023)
Get full text
Journal Article
CURTAIN-A unique web-based tool for exploration and sharing of MS-based proteomics data
Phung, Toan K, Berndsen, Kerryn, Shastry, Rosamund, Phan, Tran L C H B, Muqit, Miratul M K, Alessi, Dario R, Nirujogi, Raja S
Published in Proceedings of the National Academy of Sciences - PNAS (13.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (13.02.2024)
Get full text
Journal Article
R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils
Fan, Ying, Nirujogi, Raja S., Garrido, Alicia, Ruiz-Martínez, Javier, Bergareche-Yarza, Alberto, Mondragón-Rezola, Elisabet, Vinagre-Aragón, Ana, Croitoru, Ioana, Gorostidi Pagola, Ana, Paternain Markinez, Laura, Alcalay, Roy, Hickman, Richard A., Düring, Jonas, Gomes, Sara, Pratuseviciute, Neringa, Padmanabhan, Shalini, Valldeoriola, Francesc, Pérez Sisqués, Leticia, Malagelada, Cristina, Ximelis, Teresa, Molina Porcel, Laura, Martí, Maria José, Tolosa, Eduardo, Alessi, Dario R., Sammler, Esther M.
Published in Acta neuropathologica (01.09.2021)
Published in Acta neuropathologica (01.09.2021)
Get full text
Journal Article
Human adenine nucleotide translocases physically and functionally interact with respirasomes
Lu, Ya-Wen, Acoba, Michelle Grace, Selvaraju, Kandasamy, Huang, Tai-Chung, Nirujogi, Raja S, Sathe, Gajanan, Pandey, Akhilesh, Claypool, Steven M
Published in Molecular biology of the cell (01.06.2017)
Published in Molecular biology of the cell (01.06.2017)
Get full text
Journal Article
Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44
Malik, Nazma, Nirujogi, Raja S, Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan R, Gourlay, Robert, Trost, Matthias, Alessi, Dario R, Karapetsas, Athanasios
Published in Biochemical journal (30.10.2019)
Published in Biochemical journal (30.10.2019)
Get more information
Journal Article
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Milioto, Carmelo, Carcolé, Mireia, Giblin, Ashling, Coneys, Rachel, Attrebi, Olivia, Ahmed, Mhoriam, Harris, Samuel S., Lee, Byung Il, Yang, Mengke, Ellingford, Robert A., Nirujogi, Raja S., Biggs, Daniel, Salomonsson, Sally, Zanovello, Matteo, de Oliveira, Paula, Katona, Eszter, Glaria, Idoia, Mikheenko, Alla, Geary, Bethany, Udine, Evan, Vaizoglu, Deniz, Anoar, Sharifah, Jotangiya, Khrisha, Crowley, Gerard, Smeeth, Demelza M., Adams, Mirjam L., Niccoli, Teresa, Rademakers, Rosa, van Blitterswijk, Marka, Devoy, Anny, Hong, Soyon, Partridge, Linda, Coyne, Alyssa N., Fratta, Pietro, Alessi, Dario R., Davies, Ben, Busche, Marc Aurel, Greensmith, Linda, Fisher, Elizabeth M. C., Isaacs, Adrian M.
Published in Nature neuroscience (01.04.2024)
Published in Nature neuroscience (01.04.2024)
Get full text
Journal Article
Activation of diverse signalling pathways by oncogenic PIK3CA mutations
Wu, Xinyan, Renuse, Santosh, Sahasrabuddhe, Nandini A., Zahari, Muhammad Saddiq, Chaerkady, Raghothama, Kim, Min-Sik, Nirujogi, Raja S., Mohseni, Morassa, Kumar, Praveen, Raju, Rajesh, Zhong, Jun, Yang, Jian, Neiswinger, Johnathan, Jeong, Jun-Seop, Newman, Robert, Powers, Maureen A., Somani, Babu Lal, Gabrielson, Edward, Sukumar, Saraswati, Stearns, Vered, Qian, Jiang, Zhu, Heng, Vogelstein, Bert, Park, Ben Ho, Pandey, Akhilesh
Published in Nature communications (23.09.2014)
Published in Nature communications (23.09.2014)
Get full text
Journal Article
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1
Antico, Odetta, Ordureau, Alban, Stevens, Michael, Singh, Francois, Nirujogi, Raja S, Gierlinski, Marek, Barini, Erica, Rickwood, Mollie L, Prescott, Alan, Toth, Rachel, Ganley, Ian G, Harper, J Wade, Muqit, Miratul M K
Published in Science advances (12.11.2021)
Published in Science advances (12.11.2021)
Get full text
Journal Article
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration
Banerjee, Poulomi, Mehta, Arpan R, Nirujogi, Raja S, Cooper, James, James, Owen G, Nanda, Jyoti, Longden, James, Burr, Karen, McDade, Karina, Salzinger, Andrea, Paza, Evdokia, Newton, Judith, Story, David, Pal, Suvankar, Smith, Colin, Alessi, Dario R, Selvaraj, Bhuvaneish T, Priller, Josef, Chandran, Siddharthan
Published in Science advances (21.04.2023)
Published in Science advances (21.04.2023)
Get full text
Journal Article
Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
Pal, Prosenjit, Taylor, Matthew, Lam, Pui Yiu, Tonelli, Francesca, Hecht, Chloe A, Lis, Pawel, Nirujogi, Raja S, Phung, Toan K, Yeshaw, Wondwossen M, Jaimon, Ebsy, Fasimoye, Rotimi, Dickie, Emily A, Wightman, Melanie, Macartney, Thomas, Pfeffer, Suzanne R, Alessi, Dario R
Published in Science advances (15.12.2023)
Published in Science advances (15.12.2023)
Get full text
Journal Article
Activating Mutations in PIK3CA Lead to Widespread Modulation of the Tyrosine Phosphoproteome
Zahari, Muhammad Saddiq, Wu, Xinyan, Blair, Brian G, Pinto, Sneha M, Nirujogi, Raja S, Jelinek, Christine A, Malhotra, Radhika, Kim, Min-Sik, Park, Ben Ho, Pandey, Akhilesh
Published in Journal of proteome research (04.09.2015)
Published in Journal of proteome research (04.09.2015)
Get full text
Journal Article