Crystal structures of agonist-bound human cannabinoid receptor CB1
Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie
Published in Nature (London) (27.07.2017)
Published in Nature (London) (27.07.2017)
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Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures
Hua, Tian, Li, Xiaoting, Wu, Lijie, Iliopoulos-Tsoutsouvas, Christos, Wang, Yuxia, Wu, Meng, Shen, Ling, Brust, Christina A., Nikas, Spyros P., Song, Feng, Song, Xiyong, Yuan, Shuguang, Sun, Qianqian, Wu, Yiran, Jiang, Shan, Grim, Travis W., Benchama, Othman, Stahl, Edward L., Zvonok, Nikolai, Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Liu, Zhi-Jie
Published in Cell (20.02.2020)
Published in Cell (20.02.2020)
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Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats
Spyridakos, Dimitris, Mastrodimou, Niki, Vemuri, Kiran, Ho, Thanh C, Nikas, Spyros P, Makriyannis, Alexandros, Thermos, Kyriaki
Published in International journal of molecular sciences (23.12.2022)
Published in International journal of molecular sciences (23.12.2022)
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Structural basis for activation of CB1 by an endocannabinoid analog
Krishna Kumar, Kaavya, Robertson, Michael J., Thadhani, Elina, Wang, Haoqing, Suomivuori, Carl-Mikael, Powers, Alexander S., Ji, Lipin, Nikas, Spyros P., Dror, Ron O., Inoue, Asuka, Makriyannis, Alexandros, Skiniotis, Georgios, Kobilka, Brian
Published in Nature communications (09.05.2023)
Published in Nature communications (09.05.2023)
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Effects of cannabinoid exposure on short-term memory and medial orbitofrontal cortex function and chemistry in adolescent female rhesus macaques
Kohut, Stephen J, Cao, Lei, Mintzopolous, Dionyssios, Jiang, Shan, Nikas, Spyros P, Makriyannis, Alexandros, Zou, Chun S, Jensen, J Eric, Frederick, Blaise B, Bergman, Jack, Kangas, Brian D
Published in Frontiers in neuroscience (30.09.2022)
Published in Frontiers in neuroscience (30.09.2022)
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Altered sleep during spontaneous cannabinoid withdrawal in male mice
Missig, Galen, Mehta, Niyati, Robbins, James O, Good, Cameron H, Iliopoulos-Tsoutsouvas, Christos, Makriyannis, Alex, Nikas, Spyros P, Bergman, Jack, Carlezon, Jr, William A, Paronis, Carol A
Published in Behavioural pharmacology (01.04.2022)
Published in Behavioural pharmacology (01.04.2022)
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3′-Functionalized Adamantyl Cannabinoid Receptor Probes
Ogawa, Go, Tius, Marcus A, Zhou, Han, Nikas, Spyros P, Halikhedkar, Aneetha, Mallipeddi, Srikrishnan, Makriyannis, Alexandros
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Journal Article
Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure
Miller, Sally, Kulkarni, Shashank, Ciesielski, Alex, Nikas, Spyros P, Mackie, Ken, Makriyannis, Alexandros, Straiker, Alex
Published in Pharmaceuticals (Basel, Switzerland) (22.05.2018)
Published in Pharmaceuticals (Basel, Switzerland) (22.05.2018)
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Synthon-based ligand discovery in virtual libraries of over 11 billion compounds
Sadybekov, Arman A., Sadybekov, Anastasiia V., Liu, Yongfeng, Iliopoulos-Tsoutsouvas, Christos, Huang, Xi-Ping, Pickett, Julie, Houser, Blake, Patel, Nilkanth, Tran, Ngan K., Tong, Fei, Zvonok, Nikolai, Jain, Manish K., Savych, Olena, Radchenko, Dmytro S., Nikas, Spyros P., Petasis, Nicos A., Moroz, Yurii S., Roth, Bryan L., Makriyannis, Alexandros, Katritch, Vsevolod
Published in Nature (London) (20.01.2022)
Published in Nature (London) (20.01.2022)
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Journal Article
Crystal structures of agonist-bound human cannabinoid receptor CB 1
Hua, Tian, Vemuri, Kiran, Nikas, Spyros P, Laprairie, Robert B, Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A, Zhao, Suwen, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, Zhi-Jie
Published in Nature (London) (27.07.2017)
Published in Nature (London) (27.07.2017)
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Journal Article
Probing the Carboxyester Side Chain in Controlled Deactivation (−)‑Δ8‑Tetrahydrocannabinols
Nikas, Spyros P, Sharma, Rishi, Paronis, Carol A, Kulkarni, Shashank, Thakur, Ganesh A, Hurst, Dow, Wood, JodiAnne T, Gifford, Roger S, Rajarshi, Girija, Liu, Yingpeng, Raghav, Jimit Girish, Guo, Jason Jianxin, Järbe, Torbjörn U.C, Reggio, Patricia H, Bergman, Jack, Makriyannis, Alexandros
Published in Journal of medicinal chemistry (22.01.2015)
Published in Journal of medicinal chemistry (22.01.2015)
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Journal Article
Design and Synthesis of (13S)-Methyl-Substituted Arachidonic Acid Analogues: Templates for Novel Endocannabinoids
Papahatjis, Demetris P., Nahmias, Victoria R., Nikas, Spyros P., Schimpgen, Marion, Makriyannis, Alexandros
Published in Chemistry : a European journal (06.04.2010)
Published in Chemistry : a European journal (06.04.2010)
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Journal Article
C1‘-Cycloalkyl Side Chain Pharmacophore in Tetrahydrocannabinols
Papahatjis, Demetris P, Nahmias, Victoria R, Nikas, Spyros P, Andreou, Thanos, Alapafuja, Shakiru O, Tsotinis, Andrew, Guo, Jianxin, Fan, Pusheng, Makriyannis, Alexandros
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Journal Article
Evidence for spontaneous cannabinoid withdrawal in mice
Paronis, Carol, Iliopoulos-Tsoutsouvas, Christos, Papanastasiou, Ioannis, Makriyannis, Alex, Bergman, Jack, Nikas, Spyros P
Published in Behavioural pharmacology (01.04.2022)
Published in Behavioural pharmacology (01.04.2022)
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Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM2201
AlKhelb, Dalal, Burke, Emily L, Zvonok, Alexander, Iliopoulos-Tsoutsouvas, Christos, Georgiadis, Markos-Orestis, Jiang, Shan, Ho, Thanh C, Nikas, Spyros P, Makriyannis, Alexandros, Desai, Rajeev I
Published in European journal of pharmacology (05.12.2023)
Published in European journal of pharmacology (05.12.2023)
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Journal Article
Differential Enantiomer-Specific Signaling of Cannabidiol at CB1 Receptors
Bosquez-Berger, Taryn, Wilson, Sierra, Iliopoulos-Tsoutsouvas, Christos, Jiang, Shan, Wager-Miller, Jim, Nikas, Spyros P., Mackie, Ken P., Makriyannis, Alexandros, Straiker, Alex
Published in Molecular pharmacology (01.12.2022)
Published in Molecular pharmacology (01.12.2022)
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