Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
Tsuji, Akira, Nezu, Jun-ichi, Tamai, Ikumi, Oku, Asuka, Ohashi, Rikiya, Yabuuchi, Hikaru, Hashimoto, Noriyoshi, Nikaido, Hiroko, Sai, Yoshimichi, Koizumi, Akio, Shoji, Yutaka, Takada, Goro, Matsuishi, Toyojiro, Yoshino, Makoto, Kato, Hirohisa, Ohura, Toshihiro, Tsujimoto, Gozoh, Hayakawa, Jun-ichiro, Shimane, Miyuki
Published in Nature genetics (01.01.1999)
Published in Nature genetics (01.01.1999)
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Molecular and Physiological Evidence for Multifunctionality of Carnitine/Organic Cation Transporter OCTN2
Ohashi, R, Tamai, I, Nezu Ji, J, Nikaido, H, Hashimoto, N, Oku, A, Sai, Y, Shimane, M, Tsuji, A
Published in Molecular pharmacology (01.02.2001)
Published in Molecular pharmacology (01.02.2001)
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Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2
Inano, Akihiro, Sai, Yoshimichi, Nikaido, Hiroko, Hasimoto, Noriyoshi, Asano, Masahide, Tsuji, Akira, Tamai, Ikumi
Published in Biopharmaceutics & drug disposition (01.11.2003)
Published in Biopharmaceutics & drug disposition (01.11.2003)
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Decreased Tissue Distribution of l-Carnitine in Juvenile Visceral Steatosis Mice
Yokogawa, K, Higashi, Y, Tamai, I, Nomura, M, Hashimoto, N, Nikaido, H, Hayakawa, J, Miyamoto, K, Tsuji, A
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Gene-Dose Effect on Carnitine Transport Activity in Embryonic Fibroblasts of JVS Mice as a Model of Human Carnitine Transporter Deficiency
Hashimoto, Noriyoshi, Suzuki, Fumio, Tamai, Ikumi, Nikaido, Hiroko, Kuwajima, Masamichi, Hayakawa, Jun-Ichiro, Tsuji, Akira
Published in Biochemical pharmacology (15.05.1998)
Published in Biochemical pharmacology (15.05.1998)
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Definition of the Locus Responsible for Systemic Carnitine Deficiency within a 1.6-cM Region of Mouse Chromosome 11 by Detailed Linkage Analysis
Okita, Kohei, Tokino, Takashi, Nishimori, Hiroyuki, Miura, Koh, Nikaido, Hiroko, Hayakawa, Jun-ichiro, Ono, Akira, Kuwajima, Masamichi, Matsuzawa, Yuji, Nakamura, Yusuke
Published in Genomics (San Diego, Calif.) (15.04.1996)
Published in Genomics (San Diego, Calif.) (15.04.1996)
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Functional relevance of carnitine transporter OCTN2 to brain distribution of l‐carnitine and acetyl‐l‐carnitine across the blood–brain barrier
Kido, Yasuto, Tamai, Ikumi, Ohnari, Aki, Sai, Yoshimichi, Kagami, Toru, Nezu, Jun‐ichi, Nikaido, Hiroko, Hashimoto, Noriyoshi, Asano, Masahide, Tsuji, Akira
Published in Journal of neurochemistry (01.12.2001)
Published in Journal of neurochemistry (01.12.2001)
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Mutation of carnitine transporter OCTN2 in primary systemic carintine deficient jvs mice
Tamai, Ikumi, Ohashi, Rikiya, Nezu, Junichi, Oku, Asuka, Hashimoto, Noriyoshi, Nikaido, Hiroko, Sai, Yoshimichi, Hayakawa, Jun-ichiro, Shimane, Miyuki, Tsuji, Akira
Published in Japanese Journal of Pharmacology (1999)
Published in Japanese Journal of Pharmacology (1999)
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Loss of wild‐type carrier‐mediated L‐carnitine transport activity in hepatocytes of juvenile visceral steatosis mice
Yokogawa, Koichi, Yonekawa, Masayuki, Tamai, Ikumi, Ohashi, Rikiya, Tatsumi, Yasuaki, Higashi, Yasuhiko, Nomura, Masaaki, Hashimoto, Noriyoshi, Nikaido, Hiroko, Hayakawa, Jun‐ichiro, Nezu, Jun‐ichi, Oku, Asuka, Shimane, Miyuki, Miyamoto, Ken‐ichi, Tsuji, Akira
Published in Hepatology (Baltimore, Md.) (01.10.1999)
Published in Hepatology (Baltimore, Md.) (01.10.1999)
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Age-associated cardiomyopathy in heterozygous carrier mice of a pathological mutation of carnitine transporter gene, OCTN2
Xiaofei, E, Wada, Yasuhiko, Dakeishi, Miwako, Hirasawa, Fujiko, Murata, Katsuyuki, Masuda, Hirotake, Sugiyama, Toshihiro, Nikaido, Hiroko, Koizumi, Akio
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.07.2002)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.07.2002)
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Journal Article
Primary defect of juvenile visceral steatosis (jvs) mouse with systemic carnitine deficiency is probably in renal carnitine transport system
Horiuchi, M, Kobayashi, K, Yamaguchi, S, Shimizu, N, Koizumi, T, Nikaido, H, Hayakawa, J, Kuwajima, M, Saheki, T
Published in Biochimica et biophysica acta (12.04.1994)
Published in Biochimica et biophysica acta (12.04.1994)
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Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency
Horiuchi, Masahisa, Yoshida, Hiroki, Kobayashi, Keiko, Kuriwaki, Kazumi, Yoshimine, Kosei, Tomomura, Mineko, Koizumi, Tsutomu, Nikaido, Hiroko, Hayakawa, Junichiro, Kuwajima, Masamichi, Saheki, Takeyori
Published in FEBS letters (12.07.1993)
Published in FEBS letters (12.07.1993)
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Journal Article
Characteristics of Cardiac Hypertrophy in the Juvenile Visceral Steatosis Mouse with Systemic Carnitine Deficiency
Kuwajima, Masamichi, Lu, Kang-mo, Sei, Masako, Ono, Akira, Hayashi, Miyuki, Ishiguro, Kirie, Ozaki, Kiyokazu, Hotta, Kikuko, Okita, Kohei, Murakami, Takashi, Miyagawa, Jun-ichiro, Narama, Isao, Nikaido, Hiroko, Hayakawa, Jun-ichiro, Nakajima, Hiromu, Namba, Mitsuyoshi, Hanafusa, Toshiaki, Matsuzawa, Yuji, Shima, Kenji
Published in Journal of molecular and cellular cardiology (01.04.1998)
Published in Journal of molecular and cellular cardiology (01.04.1998)
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Journal Article
Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription
Horiuchi, M, Kobayashi, K, Tomomura, M, Kuwajima, M, Imamura, Y, Koizumi, T, Nikaido, H, Hayakawa, J, Saheki, T
Published in The Journal of biological chemistry (15.03.1992)
Published in The Journal of biological chemistry (15.03.1992)
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Abnormal expression of urea cycle enzyme genes in juvenile visceral steatosis (jvs) mice
Tomomura, M, Imamura, Y, Horiuchi, M, Koizumi, T, Nikaido, H, Hayakawa, J, Saheki, T
Published in Biochimica et biophysica acta (14.02.1992)
Published in Biochimica et biophysica acta (14.02.1992)
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Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency
Hotta, Kikuko, Kuwajima, Masamichi, Ono, Akira, Nakajima, Hiromu, Horikawa, Yukio, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi, Hanafusa, Toshiaki, Horiuchi, Masahisa, Nikaido, Hiroko, Hayakawa, Jun-ichiro, Saheki, Takeyori, Kono, Norio, Noguchi, Tamio, Matsuzawa, Yuji
Published in Diabetes research and clinical practice (01.05.1996)
Published in Diabetes research and clinical practice (01.05.1996)
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Journal Article
Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis
Hotta, K, Kuwajima, M, Ono, A, Uenaka, R, Nakajima, H, Miyagawa, J, Namba, M, Hanafusa, T, Horiuchi, M, Nikaido, H, Hayakawa, J, Kono, N, Saheki, T, Matsuzawa, Y
Published in Biochimica et biophysica acta (09.02.1996)
Published in Biochimica et biophysica acta (09.02.1996)
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