The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies
Niederst, Matthew J, Hu, Haichuan, Mulvey, Hillary E, Lockerman, Elizabeth L, Garcia, Angel R, Piotrowska, Zofia, Sequist, Lecia V, Engelman, Jeffrey A
Published in Clinical cancer research (01.09.2015)
Published in Clinical cancer research (01.09.2015)
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Journal Article
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Krishnamurthy Radhakrishna, Viveksagar, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A
Published in Nature medicine (01.03.2016)
Published in Nature medicine (01.03.2016)
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Journal Article
Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer
Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.
Published in Oncogene (01.09.2019)
Published in Oncogene (01.09.2019)
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Journal Article
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms
Hu, Haichuan, Piotrowska, Zofia, Hare, Patricia J., Chen, Huidong, Mulvey, Hillary E., Mayfield, Aislinn, Noeen, Sundus, Kattermann, Krystina, Greenberg, Max, Williams, August, Riley, Amanda K., Wilson, Jarad J., Mao, Ying-Qing, Huang, Ruo-Pan, Banwait, Mandeep K., Ho, Jeffrey, Crowther, Giovanna S., Hariri, Lida P., Heist, Rebecca S., Kodack, David P., Pinello, Luca, Shaw, Alice T., Mino-Kenudson, Mari, Hata, Aaron N., Sequist, Lecia V., Benes, Cyril H., Niederst, Matthew J., Engelman, Jeffrey A.
Published in Cancer cell (08.11.2021)
Published in Cancer cell (08.11.2021)
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Journal Article
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.
Published in Science (American Association for the Advancement of Science) (19.12.2014)
Published in Science (American Association for the Advancement of Science) (19.12.2014)
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Journal Article
Primary Patient-Derived Cancer Cells and Their Potential for Personalized Cancer Patient Care
Kodack, David P., Farago, Anna F., Dastur, Anahita, Held, Matthew A., Dardaei, Leila, Friboulet, Luc, von Flotow, Friedrich, Damon, Leah J., Lee, Dana, Parks, Melissa, Dicecca, Richard, Greenberg, Max, Kattermann, Krystina E., Riley, Amanda K., Fintelmann, Florian J., Rizzo, Coleen, Piotrowska, Zofia, Shaw, Alice T., Gainor, Justin F., Sequist, Lecia V., Niederst, Matthew J., Engelman, Jeffrey A., Benes, Cyril H.
Published in Cell reports (Cambridge) (12.12.2017)
Published in Cell reports (Cambridge) (12.12.2017)
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Journal Article
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
Niederst, Matthew J., Sequist, Lecia V., Poirier, John T., Mermel, Craig H., Lockerman, Elizabeth L., Garcia, Angel R., Katayama, Ryohei, Costa, Carlotta, Ross, Kenneth N., Moran, Teresa, Howe, Emily, Fulton, Linnea E., Mulvey, Hillary E., Bernardo, Lindsay A., Mohamoud, Farhiya, Miyoshi, Norikatsu, VanderLaan, Paul A., Costa, Daniel B., Jänne, Pasi A., Borger, Darrell R., Ramaswamy, Sridhar, Shioda, Toshi, Iafrate, Anthony J., Getz, Gad, Rudin, Charles M., Mino-Kenudson, Mari, Engelman, Jeffrey A.
Published in Nature communications (11.03.2015)
Published in Nature communications (11.03.2015)
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Journal Article
EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew J, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei-Ting, Pferdekamper, AnneMarie Culazzo, Lockerman, Elizabeth L, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, DiDonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, McNeill, Matthew, Epple, Robert, Marsilje, Thomas H, Pathan, Nuzhat, Engelman, Jeffrey A, Michellys, Pierre-Yves, McNamara, Peter, Harris, Jennifer, Bender, Steven, Kasibhatla, Shailaja
Published in Cancer research (Chicago, Ill.) (15.03.2016)
Published in Cancer research (Chicago, Ill.) (15.03.2016)
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Journal Article
Suppression of survival signalling pathways by the phosphatase PHLPP
O’Neill, Audrey K, Niederst, Matthew J, Newton, Alexandra C
Published in The FEBS journal (01.01.2013)
Published in The FEBS journal (01.01.2013)
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Journal Article
Dramatic Response to Combination Erlotinib and Crizotinib in a Patient with Advanced, EGFR-Mutant Lung Cancer Harboring De Novo MET Amplification
Gainor, Justin F., Niederst, Matthew J., Lennerz, Jochen K., Dagogo-Jack, Ibiayi, Stevens, Sara, Shaw, Alice T., Sequist, Lecia V., Engelman, Jeffrey A.
Published in Journal of thoracic oncology (01.07.2016)
Published in Journal of thoracic oncology (01.07.2016)
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Journal Article
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM
Song, Kyung-A, Niederst, Matthew J, Lochmann, Timothy L, Hata, Aaron N, Kitai, Hidenori, Ham, Jungoh, Floros, Konstantinos V, Hicks, Mark A, Hu, Haichuan, Mulvey, Hillary E, Drier, Yotam, Heisey, Daniel A R, Hughes, Mark T, Patel, Neha U, Lockerman, Elizabeth L, Garcia, Angel, Gillepsie, Shawn, Archibald, Hannah L, Gomez-Caraballo, Maria, Nulton, Tara J, Windle, Brad E, Piotrowska, Zofia, Sahingur, Sinem E, Taylor, Shirley M, Dozmorov, Mikhail, Sequist, Lecia V, Bernstein, Bradley, Ebi, Hiromichi, Engelman, Jeffrey A, Faber, Anthony C
Published in Clinical cancer research (01.01.2018)
Published in Clinical cancer research (01.01.2018)
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Journal Article
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
Krall, Elsa B, Wang, Belinda, Munoz, Diana M, Ilic, Nina, Raghavan, Srivatsan, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Aguirre, Andrew J, Kim, Jong Wook, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Doench, John G, Janne, Pasi A, Shaw, Alice T, McDonald Iii, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Hahn, William C
Published in eLife (01.02.2017)
Published in eLife (01.02.2017)
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Journal Article
Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors
Tiedt, Ralph, King, Frederick J., Stamm, Christelle, Niederst, Matthew J., Delach, Scott, Zumstein-Mecker, Sabine, Meltzer, Jodi, Mulford, Iain J., Labrot, Emma, Engstler, Barbara Schacher, Baltschukat, Sabrina, Kerr, Grainne, Golji, Javad, Wyss, Daniel, Schnell, Christian, Ainscow, Edward, Engelman, Jeffrey A., Sellers, William R., Barretina, Jordi, Caponigro, Giordano, Porta, Diana Graus
Published in Cell reports (Cambridge) (25.04.2023)
Published in Cell reports (Cambridge) (25.04.2023)
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Journal Article
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Duplaquet, Leslie, So, Kevin, Ying, Alexander W., Pal Choudhuri, Shreoshi, Li, Xinyue, Xu, Grace D., Li, Yixiang, Qiu, Xintao, Li, Rong, Singh, Shilpa, Wu, Xiaoli S., Hamilton, Seth, Chien, Victor D., Liu, Qi, Qi, Jun, Somerville, Tim D.D., Heiling, Hillary M., Mazzola, Emanuele, Lee, Yenarae, Zoller, Thomas, Vakoc, Christopher R., Doench, John G., Forrester, William C., Abrams, Tinya, Long, Henry W., Niederst, Matthew J., Drapkin, Benjamin J., Kadoch, Cigall, Oser, Matthew G.
Published in Cancer cell (12.08.2024)
Published in Cancer cell (12.08.2024)
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Journal Article
Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance
Cotton, Jennifer L., Estrada Diez, Javier, Sagar, Vivek, Chen, Julie, Piquet, Michelle, Alford, John, Song, Youngchul, Li, Xiaoyan, Riester, Markus, DiMare, Matthew T., Schumacher, Katja, Boulay, Gaylor, Sprouffske, Kathleen, Fan, Lin, Burks, Tyler, Mansur, Leandra, Wagner, Joel, Bhang, Hyo-eun C., Iartchouk, Oleg, Reece-Hoyes, John, Morris, Erick J., Hammerman, Peter S., Ruddy, David A., Korn, Joshua M., Engelman, Jeffrey A., Niederst, Matthew J.
Published in Cancer research (Chicago, Ill.) (01.11.2023)
Published in Cancer research (Chicago, Ill.) (01.11.2023)
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Journal Article
Distinct evolutionary paths to TKI resistance in NSCLC
Niederst, Matthew J., Engelman, Jeffrey A., Hata, Aaron N.
Published in Cell cycle (Georgetown, Tex.) (01.02.2018)
Published in Cell cycle (Georgetown, Tex.) (01.02.2018)
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Journal Article
Transformation from NSCLC to SCLC: when did it happen? – Authors' reply
Engelman, Jeffrey A, Oser, Matthew G, Niederst, Matthew J, Sequist, Lecia V
Published in The lancet oncology (01.07.2015)
Published in The lancet oncology (01.07.2015)
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