The Clinical Potential of Senolytic Drugs
Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.
Published in Journal of the American Geriatrics Society (JAGS) (01.10.2017)
Published in Journal of the American Geriatrics Society (JAGS) (01.10.2017)
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Journal Article
Cellular senescence: a key therapeutic target in aging and diseases
Zhang, Lei, Pitcher, Louise E, Yousefzadeh, Matthew J, Niedernhofer, Laura J, Robbins, Paul D, Zhu, Yi
Published in The Journal of clinical investigation (01.08.2022)
Published in The Journal of clinical investigation (01.08.2022)
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Journal Article
Epigenetics, DNA damage, and aging
Soto-Palma, Carolina, Niedernhofer, Laura J, Faulk, Christopher D, Dong, Xiao
Published in The Journal of clinical investigation (15.08.2022)
Published in The Journal of clinical investigation (15.08.2022)
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Journal Article
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J
Published in Annual review of pharmacology and toxicology (06.01.2021)
Published in Annual review of pharmacology and toxicology (06.01.2021)
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Journal Article
Nuclear Genomic Instability and Aging
Niedernhofer, Laura J, Gurkar, Aditi U, Wang, Yinsheng, Vijg, Jan, Hoeijmakers, Jan H.J, Robbins, Paul D
Published in Annual review of biochemistry (20.06.2018)
Published in Annual review of biochemistry (20.06.2018)
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Journal Article
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep
Published in Nature communications (16.08.2022)
Published in Nature communications (16.08.2022)
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Journal Article
Identification of HSP90 inhibitors as a novel class of senolytics
Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.
Published in Nature communications (04.09.2017)
Published in Nature communications (04.09.2017)
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Journal Article
Senolytics improve physical function and increase lifespan in old age
Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Journal Article
Role of Cellular Senescence in Type II Diabetes
Narasimhan, Akilavalli, Flores, Rafael R, Robbins, Paul D, Niedernhofer, Laura J
Published in Endocrinology (Philadelphia) (01.10.2021)
Published in Endocrinology (Philadelphia) (01.10.2021)
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Journal Article
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.
Published in Aging cell (01.06.2016)
Published in Aging cell (01.06.2016)
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Journal Article
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O’Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, Coleman, C Norman
Published in JNCI : Journal of the National Cancer Institute (01.10.2021)
Published in JNCI : Journal of the National Cancer Institute (01.10.2021)
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Journal Article
Senolytics reduce coronavirus-related mortality in old mice
Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D
Published in Science (16.07.2021)
Published in Science (16.07.2021)
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Journal Article
Web Resource
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.
Published in Aging cell (01.03.2020)
Published in Aging cell (01.03.2020)
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Journal Article
DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria
Karakasilioti, Ismene, Kamileri, Irene, Chatzinikolaou, Georgia, Kosteas, Theodoros, Vergadi, Eleni, Robinson, Andria Rasile, Tsamardinos, Iannis, Rozgaja, Tania A., Siakouli, Sandra, Tsatsanis, Christos, Niedernhofer, Laura J., Garinis, George A.
Published in Cell metabolism (03.09.2013)
Published in Cell metabolism (03.09.2013)
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Journal Article
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Farr, Joshua N, Saul, Dominik, Doolittle, Madison L, Kaur, Japneet, Rowsey, Jennifer L, Vos, Stephanie J, Froemming, Mitchell N, Lagnado, Anthony B, Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J, Niedernhofer, Laura J, Robbins, Paul D, Jurk, Diana, Passos, João F, LeBrasseur, Nathan K, Tchkonia, Tamara, Kirkland, James L, Monroe, David G, Khosla, Sundeep
Published in The Journal of clinical investigation (17.04.2023)
Published in The Journal of clinical investigation (17.04.2023)
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Journal Article
Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome
Mu, Xiaodong, Tseng, Chieh, Hambright, William S., Matre, Polina, Lin, Chih‐Yi, Chanda, Palas, Chen, Wanqun, Gu, Jianhua, Ravuri, Sudheer, Cui, Yan, Zhong, Ling, Cooke, John P., Niedernhofer, Laura J., Robbins, Paul D., Huard, Johnny
Published in Aging cell (01.08.2020)
Published in Aging cell (01.08.2020)
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Journal Article
Extending human healthspan and longevity: a symposium report
DeVito, Loren M., Barzilai, Nir, Cuervo, Ana Maria, Niedernhofer, Laura J., Milman, Sofiya, Levine, Morgan, Promislow, Daniel, Ferrucci, Luigi, Kuchel, George A., Mannick, Joan, Justice, Jamie, Gonzales, Mitzi M., Kirkland, James L., Cohen, Pinchas, Campisi, Judith
Published in Annals of the New York Academy of Sciences (01.01.2022)
Published in Annals of the New York Academy of Sciences (01.01.2022)
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Journal Article
Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease
Xun, Zhiyin, Rivera-Sánchez, Sulay, Ayala-Peña, Sylvette, Lim, James, Budworth, Helen, Skoda, Erin M., Robbins, Paul D., Niedernhofer, Laura J., Wipf, Peter, McMurray, Cynthia T.
Published in Cell reports (Cambridge) (29.11.2012)
Published in Cell reports (Cambridge) (29.11.2012)
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Journal Article
ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair
Ahmad, Anwaar, Robinson, Andria Rasile, Duensing, Anette, van Drunen, Ellen, Beverloo, H. Berna, Weisberg, David B., Hasty, Paul, Hoeijmakers, Jan H. J., Niedernhofer, Laura J.
Published in Molecular and Cellular Biology (01.08.2008)
Published in Molecular and Cellular Biology (01.08.2008)
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Journal Article
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuris, Niedernhofer, Laura J, Pereira, Karla, Robbins, Paul D, Silva, Alexa, Suarez, Gisela M, Berghe, Wim Vanden, von Zglinicki, Thomas, Pawelec, Graham, Lage, Agustín
Published in Immunity & ageing (08.06.2023)
Published in Immunity & ageing (08.06.2023)
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