RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
Su, Fei, Viros, Amaya, Milagre, Carla, Trunzer, Kerstin, Bollag, Gideon, Spleiss, Olivia, Reis-Filho, Jorge S, Kong, Xiangju, Koya, Richard C, Flaherty, Keith T, Chapman, Paul B, Kim, Min Jung, Hayward, Robert, Martin, Matthew, Yang, Hong, Wang, Qiongqing, Hilton, Holly, Hang, Julie S, Noe, Johannes, Lambros, Maryou, Geyer, Felipe, Dhomen, Nathalie, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Zambon, Alfonso, Preece, Natasha, Robert, Lídia, Otte, Nicholas J, Mok, Stephen, Kee, Damien, Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A, Wong, Bernice, Nguyen, Hoa, Kockx, Mark, Andries, Luc, Lestini, Brian, Nolop, Keith B, Lee, Richard J, Joe, Andrew K, Troy, James L, Gonzalez, Rene, Hutson, Thomas E, Puzanov, Igor, Chmielowski, Bartosz, Springer, Caroline J, McArthur, Grant A, Sosman, Jeffrey A, Lo, Roger S, Ribas, Antoni, Marais, Richard
Published in The New England journal of medicine (19.01.2012)
Published in The New England journal of medicine (19.01.2012)
Get full text
Journal Article
Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard
Published in Cancer cell (13.12.2011)
Published in Cancer cell (13.12.2011)
Get full text
Journal Article
Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes
Pedersen, Malin, Küsters-Vandevelde, Heidi V N, Viros, Amaya, Groenen, Patricia J T A, Sanchez-Laorden, Berta, Gilhuis, Jacobus H, van Engen-van Grunsven, Ilse A, Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Marais, Richard
Published in Cancer discovery (01.04.2013)
Published in Cancer discovery (01.04.2013)
Get full text
Journal Article
BRAF as a therapeutic target: a patent review (2006 - 2012)
Zambon, Alfonso, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Marais, Richard, Springer, Caroline J
Published in Expert opinion on therapeutic patents (01.02.2013)
Published in Expert opinion on therapeutic patents (01.02.2013)
Get more information
Journal Article
1-(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO[2,3-B]PYRAZIN-8-YL)OXY]PHENYL]UREA DERIVATIVES AS RAF INHIBITORS FOR THE TREATMENT OF CANCER
NICULESCU DUVAZ ION, GIROTTI ROMINA, NICULESCU DUVAZ DAN, ZAMBON ALFONSO, MARAIS RICHARD, SPRINGER CAROLINE JOY
Year of Publication 06.07.2016
Get full text
Year of Publication 06.07.2016
Patent
Gene Regulation in Cancer Gene Therapy Strategies
SCANLON, Ian, LEHOURITIS, Panos, NICULESCU-DUVAZ, Ion, MARAIS, Richard, SPRINGER, Caroline J
Published in Current medicinal chemistry (01.10.2003)
Published in Current medicinal chemistry (01.10.2003)
Get full text
Journal Article
Small molecule inhibitors of BRAF in clinical trials
Zambon, Alfonso, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Get full text
Journal Article
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts
BLAKEY, D. C, BURKE, P. J, PINDER, P. E, SHARMA, S. K, WRIGHT, A. F, SPRINGER, C. J, DAVIES, D. H, DOWELL, R. I, EAST, S. J, ECKERSLEY, K. P, FITTON, J. E, MCDAID, J, MELTON, R. G, NICULESCU-DUVAZ, I. A
Published in Cancer research (Chicago, Ill.) (15.07.1996)
Get full text
Published in Cancer research (Chicago, Ill.) (15.07.1996)
Journal Article
Abstract LB-212: Therapeutic efficacy of the paradox-breaking panRAF and SRC drug CCT3833/BAL3833 in KRAS-driven cancer models
Saturno, Grazia, Lopes, Filipa, Girotti, Maria Romina, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Johnson, Louise, Preece, Natasha, Viros, Amaya, Pedersen, Malin, McLeary, Robert, Knight, Ruth, Lee, Rebecca, Holovanchuk, Denys, Lorigan, Paul, Dhomen, Nathalie, Marais, Richard, Springer, Caroline
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents
Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline J.
Published in Bioorganic & medicinal chemistry (01.03.2013)
Published in Bioorganic & medicinal chemistry (01.03.2013)
Get full text
Journal Article
A Phase 1 first-in-human trial to evaluate the safety and tolerability of CCT3833, an oral panRAF inhibitor, in patients with advanced solid tumours, including metastatic melanoma
Dean, Emma Jane, Banerji, Udai, Girotti, Romina, Niculescu-Duvaz, Ion, Lopes, Filipa, Davies, Lawrence, Niculescu-Duvaz, Dan, Dhomen, Natalie, Ellis, Sally, Ali, Zohra, O'Carrigan, Brent, Carter, Louise, Chisolm, Luke, Dive, Caroline, Lane, Heidi A, Lorigan, Paul, Gore, Martin Eric, Larkin, James, Marais, Richard, Springer, Caroline
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
Get full text
Journal Article
Novel Hinge Binder Improves Activity and Pharmacokinetic Properties of BRAF Inhibitors
Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M, Niculescu-Duvaz, Ion, Whittaker, Steven, Niculescu-Duvaz, Dan, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A, Lopes, Filipa, Preece, Natasha, Hedley, Douglas, Ogilvie, Lesley M, Kirk, Ruth, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
Get full text
Journal Article
Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring
Ménard, Delphine, Niculescu-Duvaz, Ion, Dijkstra, Harmen P, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M, Zambon, Alfonso, Nourry, Arnaud, Roman, Esteban, Davies, Lawrence, Manne, Helen A, Friedlos, Frank, Kirk, Ruth, Whittaker, Steven, Gill, Adrian, Taylor, Richard D, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
Get full text
Journal Article
Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold
Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R, Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J, Davies, Lawrence C, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
Get full text
Journal Article
Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)
Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P, Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M, Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Whittaker, Steven, Kirk, Ruth, Gill, Adrian, Taylor, Richard D, Raynaud, Florence I, Moreno-Farre, Javier, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
Get full text
Journal Article
Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group
Suijkerbuijk, Bart M. J. M, Niculescu-Duvaz, Ion, Gaulon, Catherine, Dijkstra, Harmen P, Niculescu-Duvaz, Dan, Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A, Friedlos, Frank, Ogilvie, Lesley M, Hedley, Douglas, Lopes, Filipa, Preece, Natasha P. U, Moreno-Farre, Javier, Raynaud, Florence I, Kirk, Ruth, Whittaker, Steven, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
Get full text
Journal Article
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Takle, Andrew K., Wilson, David M., Pons, Jean-Francois, Coulter, Tom, Kirk, Ruth, Cantarino, Neus, Whittaker, Steven, Marais, Richard, Springer, Caroline J.
Published in Bioorganic & medicinal chemistry (15.09.2010)
Published in Bioorganic & medicinal chemistry (15.09.2010)
Get full text
Journal Article